4.8 Article

A Purposefully Designed pH/GSH-Responsive MnFe-Based Metal-Organic Frameworks as Cascade Nanoreactor for Enhanced Chemo-Chemodynamic-Starvation Synergistic Therapy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Biodegradable Metal-Organic-Framework-Gated Organosilica for Tumor-Microenvironment-Unlocked Glutathione-Depletion-Enhanced Synergistic Therapy

Yuanyuan Ma et al.

Summary: This study achieved targeted delivery of cisplatin using biocompatible and biodegradable hollow mesoporous organosilica (HMOS) nanoparticles by blocking the pores with a bimetallic Zn2+/Cu2+ co-doped metal-organic framework (MOF). The MOF decomposes in the acidic tumor microenvironment to release cisplatin for chemotherapy, while the released Cu2+ depletes intracellular glutathione (GSH) and catalyzes the decomposition of intratumoral H2O2 into highly toxic •OH for chemodynamic therapy. The reduced GSH also protects the •OH from scavenging, enhancing the chemodynamic therapy effect.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Multifunctional Biomimetic Nanovaccines Based on Photothermal and Weak-Immunostimulatory Nanoparticulate Cores for the Immunotherapy of Solid Tumors

Jiachen Li et al.

Summary: An alternative strategy using photothermal and weak-immunostimulatory porous silicon@Au nanocomposites as particulate cores to prepare a biomimetic nanovaccine is reported. This strategy improves the biosafety and immunotherapeutic efficacy for solid tumors. The nanovaccine efficiently delivers cancer cell membranes into dendritic cells to activate antitumor immunity, resulting in no occurrence of solid tumors and the survival of all immunized mice. Additionally, the nanovaccine synergized with additional immunotherapies can inhibit the growth and metastasis of established solid tumors by initiating antitumor immune responses and reversing immunosuppressive microenvironments.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Enhancing Tumor Catalytic Therapy by Co-Catalysis

Jiacai Yang et al.

Summary: In this study, a co-catalytic concept was introduced to enhance the efficacy of Fenton reactions in tumor catalytic therapy by dispersing single-atom iron species on two-dimensional molybdenum disulfide nanosheets. The iron species act as active sites for triggering the Fenton reactions, while the sulfur vacancies on the nanosheets promote hydroxyl radical production. Moreover, the nanosheets also serve as a co-catalyst to accelerate the conversion of iron ions and promote the overall catalytic process. The study demonstrates the feasibility of applying this co-catalytic concept to improve anticancer efficacy both in vitro and in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Chemistry, Multidisciplinary

Copper-Based Metal-Organic Framework Overcomes CancerChemoresistance through Systemically Disrupting DynamicallyBalanced Cellular Redox Homeostasis

Jia Liu et al.

Summary: This study presents a copper/catechol-based metal-organic framework that disrupts the redox homeostasis in drug-resistant cancer cells, leading to increased cellular oxidative stress and selective cytotoxicity. The framework effectively inhibits in vivo drug-resistant tumor growth and improves survival rates in tumor-bearing mice.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

Near-Infrared-II Plasmonic Trienzyme-Integrated Metal-Organic Frameworks with High-Efficiency Enzyme Cascades for Synergistic Trimodal Oncotherapy

Guangzhi Zhou et al.

Summary: This study presents a plasmonic trienzyme-integrated metal-organic framework (plasEnMOF) nanoplatform for synergistic therapy of hypoxic tumors. The encapsulation of NIR-II plasmonic Au nanorods and natural enzymes allowed for efficient depletion of intratumoral glucose and generation of toxic reactive oxygen species for cancer therapy.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Lian-Hua Fu et al.

Summary: Chemodynamic therapy (CDT) is a promising method for killing cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals ((OH)-O-center dot). An intelligent nanocatalytic theranostics, PGC-DOX, was developed to address the limitations of endogenous H2O2 and high GSH levels in tumor cells, leading to efficient cancer therapy. The system combines H2O2 self-supply, GSH-elimination, and DOX-induced chemotherapy to effectively inhibit tumor growth with minimal side effects in vivo.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Hui Hu et al.

Summary: The rapid growth of nanomedicine and nanobiotechnology has enabled the emergence of distinctive disease-specific therapeutic modalities, specifically nanomedicine-enabled/augmented nanodynamic therapy (NDT). These modalities include different approaches such as sonodynamic therapy, thermodynamic therapy, electrodynamic therapy, and others, aiming to enhance disease-specific treatment with reduced side effects.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Yang Zhu et al.

Summary: The Mn/PSAE constructed here demonstrates significant catalytic activity in weakly acidic tumor environments, which enables the generation of sufficient reactive oxygen species (ROS) through a series of cascade reactions to effectively kill tumor cells.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Constructing Electron Levers in Perovskite Nanocrystals to Regulate the Local Electron Density for Intensive Chemodynamic Therapy

Peiran Zhao et al.

Summary: By regulating the electron density of reaction center atoms, this study has successfully increased the catalytic activity of Fe, reduced the activation energy of the Fenton reaction, and increased the (OH)-O- production rate. This provides a new possibility for highly effective chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Chemistry, Inorganic & Nuclear

Platinum(IV) antitumor complexes and their nano-drug delivery

Chunyan Jia et al.

Summary: This article summarizes the main problems of platinum-based anticancer drugs, introduces Pt-IV drugs and their characteristics, and focuses on the combination therapy with nanocarriers, looking forward to the application prospects of Pt-IV drugs and nanotechnology in the field of cancer chemotherapy.

COORDINATION CHEMISTRY REVIEWS (2021)

Article Engineering, Biomedical

Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH-Activated, Synergistic Effect/H2O2 Self-Supply-Mediated Cascade Fenton Chemistry

Hao Zhou et al.

Summary: This paper introduces the fabrication of Fenton-type bimetallic peroxides for ultrasensitive chemodynamic therapy with high pH-activated, synergistic effect/H2O2 self-supply-mediated cascade Fenton chemistry. These bimetallic peroxides exhibit high-efficiency tumor catalytic therapy with negligible side effects in vivo, and will likely drive interest in developing smart high-efficiency nanoplatforms for cancer theranostics.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Chemistry, Multidisciplinary

Tailoring Supramolecular Prodrug Nanoassemblies for Reactive Nitrogen Species-Potentiated Chemotherapy of Liver Cancer

Yongyan Deng et al.

Summary: This study reports a novel supramolecular prodrug nanoassemblies strategy that co-delivers nitric oxide and superoxide anion inducing chemotherapeutic agents for enhanced reactive nitrogen species effects in chemotherapy. The efficacy of this strategy was validated in hepatoma models, providing a new direction for cancer treatment.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Target Reprogramming Lysosomes of CD8+T Cells by a Mineralized Metal-Organic Framework for Cancer Immunotherapy

Qin Zhao et al.

Summary: The study introduces a lysosome-targeting nanoparticle developed from a mineralized metal-organic framework coupled with a lysosome-targeting aptamer to enhance the antitumor effect of T cells. The MOF synthesized from Zn2+ and dimethylimidazole has good protein encapsulation and acid sensitivity, making it an ideal lysosomal delivery vector. The use of calcium carbonate to induce MOF mineralization improves stability and provides synergistic effects for encapsulating therapeutic proteins.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

A Systematic Strategy of Combinational Blow for Overcoming Cascade Drug Resistance via NIR-Light-Triggered Hyperthermia

Lingna Wang et al.

Summary: A systematic combination strategy utilizing near-infrared light-triggered hyperthermia, combined with cisplatin, was proposed to overcome drug resistance. The strategy showed significant efficacy in inhibiting the growth of multidrug-resistant lung cancer in both in vitro and in vivo studies.

ADVANCED MATERIALS (2021)

Article Biochemistry & Molecular Biology

Syringic acid regulates suppression of the STAT3/JNK/AKT pathway via inhibition of human ovarian teratoma cancer cell (PA-1) growth-in vitro study

Lina Yang et al.

Summary: Syringic acid (SRA) exhibits proapoptotic activities on ovarian cancer cells, suppressing cell proliferation and migration through regulation of cell cycle and apoptosis-related proteins.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Engineering, Biomedical

Biodegradable Copper-Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors

Runxiao Zheng et al.

Summary: The CCMZ NPs are designed to enhance CDT efficacy by inhibiting HO-1 activity, depleting GSH, and converting hydrogen peroxide into hydroxyl radical to eliminate tumor cells efficiently.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Multifunctional metal-organic framework heterostructures for enhanced cancer therapy

Jintong Liu et al.

Summary: Metal-organic frameworks (MOFs) are a class of molecular crystalline materials that can hierarchically integrate nanoparticles and/or biomolecules, enabling multifunctionality. Their benefits in cancer therapy lie in enhancing catalytic capacity of nanoparticles and retaining biological activity of biomolecules within intracellular environments.

CHEMICAL SOCIETY REVIEWS (2021)

Review Oncology

The rediscovery of platinum-based cancer therapy

Sven Rottenberg et al.

Summary: Platinum chemotherapy agents continue to be widely used in cancer treatment, with recent insights into DNA repair mechanisms providing valuable explanations for their success. The understanding of defective DNA repair in many cancers sheds new light on secondary drug resistance mechanisms.

NATURE REVIEWS CANCER (2021)

Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Engineering, Biomedical

Metal-organic frameworks for stimuli-responsive drug delivery

Ying Wang et al.

BIOMATERIALS (2020)

Article Chemistry, Multidisciplinary

Metal-Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

Evelyn Ploetz et al.

ADVANCED MATERIALS (2020)

Review Chemistry, Inorganic & Nuclear

Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review

Abhijeet Pandey et al.

COORDINATION CHEMISTRY REVIEWS (2020)

Article Chemistry, Multidisciplinary

Photoactivated Nanosheets Accelerate Nucleus Access of Cisplatin for Drug-Resistant Cancer Therapy

Fang Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Metal-Organic-Framework-Engineered Enzyme-Mimetic Catalysts

Lang Ma et al.

ADVANCED MATERIALS (2020)

Article Toxicology

Syringic acid triggers reactive oxygen species-mediated cytotoxicity in HepG2 cells

S. Gheena et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2019)

Article Chemistry, Multidisciplinary

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy using CaCO3 Mineralized Metal-Organic Framework

Xiuyan Wan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Multidisciplinary

Stimuli-Responsive Therapeutic Metallodrugs

Xiaohui Wang et al.

CHEMICAL REVIEWS (2019)

Article Chemistry, Multidisciplinary

Metal Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

Wen Cai et al.

ADVANCED SCIENCE (2019)

Review Nanoscience & Nanotechnology

Nanomaterials derived from metal-organic frameworks

Song Dang et al.

NATURE REVIEWS MATERIALS (2018)

Review Medicine, Research & Experimental

Syringic acid (SA) - A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance

Srinivasulu Cheemanapalli et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Pharmacology & Pharmacy

Recent advances of cocktail chemotherapy by combination drug delivery systems

Quanyin Hu et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Review Materials Science, Biomaterials

Stimuli responsive drug delivery application of polymer and silica in biomedicine

Arif Gulzar et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Review Chemistry, Physical

Stimuli-responsive nanocarriers for drug delivery

Simona Mura et al.

NATURE MATERIALS (2013)

Article Chemistry, Multidisciplinary

Nanoscale coordination polymers for platinum-based anticancer drug delivery

William J. Rieter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)