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Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood-Brain Barrier

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A biodegradable nanocapsule for through-skull NIR-II fluorescence imaging/magnetic resonance imaging and selectively enhanced radio-chemotherapy for orthotopic glioma

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Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

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AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

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NIR-II fluorescence visualization of ultrasound-induced blood-brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles

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Summary: In this study, microbubbles (MBs) doped with indocyanine green (ICG) were used to visualize the blood-brain barrier (BBB) opening induced by focused ultrasound (FUS) and enhance photothermal therapy (PTT) against glioblastoma (GBM). MBs-ICG exhibited bright fluorescence in the second near-infrared window (NIR-II), ultrasound contrast, and ultrasound-induced size transformation properties. By combining MBs-ICG with FUS, the BBB opening process could be visualized in real time with a high signal-to-background ratio.

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Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics

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Summary: This study presents a glioma targeting and redox activatable theranostic nanoprobe for on-demand synergistic chemotherapy/photodynamic therapy (Chemo-PDT) of orthotopic gliomas. The nanoprobe disassembles and releases small molecules upon reduction by endogenous glutathione, allowing for synergistic Chemo-PDT. Additionally, the nanoprobe is capable of noninvasive detection and monitoring of orthotopic brain tumor growth. This research highlights the potential of targeted and activatable nanoagents for combinational cancer theranostics.

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Biopolymer Nanoparticles for Nose-to-Brain Drug Delivery: A New Promising Approach for the Treatment of Neurological Diseases

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Summary: This article discusses the use of polymer nanoparticles to deliver drugs to the brain through the nose-to-brain route. This method is currently being widely used for the treatment of neurological diseases such as glioblastoma and neurodegenerative diseases.

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Article Biochemistry & Molecular Biology

Exploration and functionalization of M1-macrophage extracellular vesicles for effective accumulation in glioblastoma and strong synergistic therapeutic effects

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Summary: The researchers successfully developed M1-like macrophage-derived extracellular vesicles (M1EVs) for the treatment of glioblastoma multiforme (GBM). These M1EVs achieved synergistic immunomodulation, chemiexcited photodynamic therapy (CDT), and hypoxia-activated chemotherapy in GBM, leading to a potent therapeutic effect. The results demonstrated the excellent efficacy of CCA-M1EVs against GBM in cell-derived and patient-derived xenograft models.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Chemistry, Physical

Silicon-based nanoprobes cross the blood-brain barrier for photothermal therapy of glioblastoma

Rong Sun et al.

Summary: The newly developed SiNPs-based nanoprobes can effectively bypass the blood-brain barrier and accumulate in GBM tissues. Compared with free ICG, G-ICG-SiNPs exhibit stronger stability and longer blood circulation time, indicating superior photothermal effects.

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Iron oxide nanoparticle-mediated radiation delivery for glioblastoma treatment

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Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

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AAPS JOURNAL (2021)

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Article Chemistry, Multidisciplinary

A Microfluidics-Based Scalable Approach to Generate Extracellular Vesicles with Enhanced Therapeutic MicroRNA Loading for Intranasal Delivery to Mouse Glioblastomas

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Summary: A scalable microfluidic platform was developed to load therapeutic miRNAs and drugs into EVs while controlling their size, leading to improved treatment outcomes in orthotopic GBM mouse models. The engineered mpEVs demonstrated efficient delivery of miRNAs and drugs to GBM cells, resulting in tumor regression and increased survival rates in mice, showing potential for clinical translation in GBM therapy.

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Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

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Summary: This review focuses on nanoscale brain-targeting drug delivery strategies designed based on blood-brain barrier (BBB) alterations and their applications in various brain diseases. However, advances on optimization of small molecules for BBB crossing and non-systemic administration routes such as intranasal treatment are not included in this review.

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Tumor cell-targeting radiotherapy in the treatment of glioblastoma multiforme using linear accelerators

Chih-Sheng Chiang et al.

Summary: TSER is a strategy for achieving precision cell-targeted radiotherapy using common linear accelerators, involving a combination of GoldenDisk, 5-ALA, low-intensity ultrasound, and low-dose radiation therapy. It exhibited synergized radiosensitization effects and showed enhanced therapeutic effect and survival in the treatment of an orthotropic GBM model with only 20% of the radiation dose.

ACTA BIOMATERIALIA (2021)

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Article Oncology

MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors

Ying Meng et al.

Summary: This study demonstrates that MRgFUS has the potential to enrich circulating brain-derived biomarkers, showing promising applications for liquid biopsy in the brain.

NEURO-ONCOLOGY (2021)

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Review Chemistry, Multidisciplinary

Development of Polymeric Nanoparticles for Blood-Brain Barrier Transfer-Strategies and Challenges

Weisen Zhang et al.

Summary: Polymeric nanoparticles have shown great potential in overcoming the blood-brain barrier for effective drug delivery, with their unique properties offering high tunability and ease of synthesis. Careful analysis of their performance in transporting drugs across the blood-brain barrier is essential for successful drug delivery to the central nervous system.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Interfacially Engineered ZnxMn1-xS@Polydopamine Hollow Nanospheres for Glutathione Depleting Photothermally Enhanced Chemodynamic Therapy

Juan Ruan et al.

Summary: The Fenton-like reactions driven by manganese-based nanostructures can be tuned by a controllable release of Mn ions, leading to specific toxicity to cancer cells. The ZnxMn1-xS@PDA composites show potential for synergistic chemodynamic and photothermal therapies for cancer treatment.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Cation-Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy

Tong Jiang et al.

Summary: The novel cation-free siRNA micelles show enhanced blood circulation time, superior cell uptake, potent BBB penetration, and no charge-associated toxicity, resulting in outstanding growth inhibition of orthotopic U87MG xenografts and remarkably improved survival benefits for GBM treatment. Additionally, these siRNA micelles display effective drug loading ability, and when combined with temozolomide, they achieve effective synergistic therapy by targeting key drug-resistant pathways. The siRNA micelle nanoparticle serves as a robust and versatile drug co-delivery platform for effective GBM treatment.

ADVANCED MATERIALS (2021)

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Review Materials Science, Biomaterials

Unravelling the potential of graphene in glioblastoma therapy

Cher Ying Foo et al.

Summary: Glioblastoma multiforme is a highly malignant type of tumor with poor prognosis. The use of graphene, a nanomaterial with unique characteristics, has shown promise in overcoming challenges in GBM treatment by providing a versatile platform for multiple therapeutic modalities. This review discusses the current applications of graphene-based materials in GBM diagnosis and therapy, highlighting potential pathways towards improving the safety and efficacy of graphene-based therapeutics.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Multidisciplinary Sciences

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

Simone Brioschi et al.

Summary: The meninges contain adaptive immune cells called B cells that are thought to originate locally from the calvaria, providing a constant supply of CNS-educated B cells. Additionally, a subset of antigen-experienced B cells in the meninges of aging mice are found to be blood-borne, suggesting a potential mechanism for maintaining immune privilege within the CNS.

SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation

Yufu Zhu et al.

Summary: The study synthesized reactive oxygen species (ROS)-triggered poly(propylene sulfide)60 (PPS60) mixed with matrix metalloproteinases (MMPs)-responsive triglycerol monostearate (T) lipids and TMZ to generate hydrogels with MMPs- and ROS-responsiveness. The hydrogel effectively inhibited the growth of recurrent glioma after surgery by achieving the sustained release of TMZ in the surgical cavity.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

RVG-functionalized reduction sensitive micelles for the effective accumulation of doxorubicin in brain

Jiangkang Xu et al.

Summary: The study demonstrated that RVG-modified nanomicelles can enhance drug accumulation in the brain and inhibit tumor growth effectively, leading to significantly improved survival rate with minimal systemic toxicity.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Image-guided selection of Gd@C-dots as sensitizers to improve radiotherapy of non-small cell lung cancer

Xiaofen Ma et al.

Summary: In this study, two Gd@C-dots formulations were developed with carboxylic acid (CA-Gd@C-dots) or amino group (pPD-Gd@C-dots) on the carbon shell. PET imaging showed significantly improved tumor retention of Cu-64-labeled pPD-Gd@C-dots compared to CA-Gd@C-dots, indicating the potential of pPD-Gd@C-dots as an effective radiosensitizer for cancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel

Mathilde Bouche et al.

Summary: A injectable hydrogel loaded with quisinostat drug and gold nanoparticles was successfully used to inhibit tumor growth in glioblastoma, showing high anticancer activity in vitro. By combining radiotherapy and radiation-triggered drug delivery, the hydrogel demonstrated a total response rate of 67% in a mice model. The use of gold nanoparticles allowed for precise image-guided radiation delivery and monitoring of hydrogel degradation using computed tomography.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

Angiopep2-Conjugated Star-Shaped Polyprodrug Amphiphiles for Simultaneous Glioma-Targeting Therapy and MR Imaging

Xiao Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Toxicology

Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

Hye-Yeon Choi et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

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Article Chemistry, Multidisciplinary

Near Infrared Fluorescent Nanoplatform for Targeted Intraoperative Resection and Chemotherapeutic Treatment of Glioblastoma

Derek Reichel et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

Physical triggering strategies for drug delivery

Tao Sun et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Biomimetic Nanocomposites Cloaked with Bioorthogonally Labeled Glioblastoma Cell Membrane for Targeted Multimodal Imaging of Brain Tumors

Yukun Duan et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Rabies Virus-Inspired Metal-Organic Frameworks (MOFs) for Targeted Imaging and Chemotherapy of Glioma

Chaoqiang Qiao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Oncology

Management of glioblastoma: State of the art and future directions

Aaron C. Tan et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

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Article Chemistry, Multidisciplinary

Natural-Killer-Cell-Inspired Nanorobots with Aggregation-Induced Emission Characteristics for Near-Infrared-II Fluorescence-Guided Glioma Theranostics

Guanjun Deng et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

Gold Nanoparticles in Glioma Theranostics

Mohammad Norouzi

PHARMACOLOGICAL RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Ultrastable AgBiS2 Hollow Nanospheres with Cancer Cell-Specific Cytotoxicity for Multimodal Tumor Therapy

Benjin Chen et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma

Giulia Brachi et al.

NANOSCALE (2020)

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Review Oncology

Central Nervous System Cancers Version 3.2020

Louis Burt Nabors et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

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Article Chemistry, Multidisciplinary

Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

Qingwei Zhu et al.

ADVANCED SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

Zhilan Chai et al.

ACS NANO (2019)

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Article Multidisciplinary Sciences

A biosensor capable of identifying low quantities of breast cancer cells by electrical impedance spectroscopy

L. F. E. Huerta-Nunez et al.

SCIENTIFIC REPORTS (2019)

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Review Clinical Neurology

Assessment of Glioblastoma Response in the Era of Bevacizumab: Longstanding and Emergent Challenges in the Imaging Evaluation of Pseudoresponse

Octavio D. Arevalo et al.

FRONTIERS IN NEUROLOGY (2019)

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Article Chemistry, Multidisciplinary

Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis

Golnaz Morad et al.

ACS NANO (2019)

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Review Chemistry, Physical

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood-Brain Barrier to Treatment

Shruti Mendiratta et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2019)

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Review Biochemistry & Molecular Biology

Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials

Franciele Aline Bruinsmann et al.

MOLECULES (2019)

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Review Biotechnology & Applied Microbiology

microRNAs: Potential glioblastoma radiosensitizer by targeting radiation-related molecular pathways

Mohammad-Taghi Bahreyni-Toossi et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2019)

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Article Multidisciplinary Sciences

Brain-targeted drug delivery by manipulating protein corona functions

Zui Zhang et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles

Yali Jia et al.

ACS NANO (2019)

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Article Chemistry, Medicinal

Liposomes actively recognizing the glucose transporter GLUT1 and integrin αvβ3 for dual-targeting of glioma

Qiuyi Fu et al.

ARCHIV DER PHARMAZIE (2019)

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Review Engineering, Biomedical

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Jinbing Xie et al.

BIOMATERIALS (2019)

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Article Clinical Neurology

Hyperosmotic intraventricular drug delivery of DV1 in the management of intracranial metastatic breast cancer in a mouse model

Satish Krishnamurthy et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2019)

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Article Neurosciences

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections

Ruiyao Cai et al.

NATURE NEUROSCIENCE (2019)

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Review Clinical Neurology

Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond

Anna M. Krichevsky et al.

NEUROTHERAPEUTICS (2019)

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Article Chemistry, Multidisciplinary

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

Gulsah Erel-Akbaba et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

Lei Han et al.

ADVANCED MATERIALS (2019)

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Article Critical Care Medicine

Inhibition of Vascular Endothelial Cell Leak Following Escherichia coli Attachment in an Experimental Model of Sepsis

Tony M. McHale et al.

CRITICAL CARE MEDICINE (2018)

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Review Medicine, Research & Experimental

Mechanism of intranasal drug delivery directly to the brain

Tyler P. Crowe et al.

LIFE SCIENCES (2018)

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Article Biotechnology & Applied Microbiology

Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma

Christine E. Brown et al.

MOLECULAR THERAPY (2018)

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Review Oncology

Current state of immunotherapy for glioblastoma

Michael Lim et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Biology

Theranostical application of nanomedicine for treating central nervous system disorders

Wang Ran et al.

SCIENCE CHINA-LIFE SCIENCES (2018)

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Article Multidisciplinary Sciences

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

Kaiyuan Ni et al.

NATURE COMMUNICATIONS (2018)

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Article Neurosciences

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Fanny Herisson et al.

NATURE NEUROSCIENCE (2018)

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Article Chemistry, Multidisciplinary

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

Zheyu Shen et al.

ACS NANO (2018)

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Article Multidisciplinary Sciences

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Meiying Wu et al.

NATURE COMMUNICATIONS (2018)

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Article Biotechnology & Applied Microbiology

Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats

Minghan Shi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Liposomal temozolomide drug delivery using convection enhanced delivery

Mirjam M. Nordling-David et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Chemistry, Multidisciplinary

Photoacoustic-Guided Surgery with Indocyanine Green-Coated Superparamagnetic Iron Oxide Nanoparticle Clusters

Jayesh P. Thawani et al.

SMALL (2017)

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Article Biotechnology & Applied Microbiology

Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro

Huai-Lu Chen et al.

JOURNAL OF NANOBIOTECHNOLOGY (2017)

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Article Chemistry, Multidisciplinary

pH-Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

Jingjing Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Chemistry, Multidisciplinary

Continuous Hydrothermal Synthesis of Inorganic Nanoparticles: Applications and Future Directions

Jawwad A. Darr et al.

CHEMICAL REVIEWS (2017)

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Article Oncology

The Microenvironmental Landscape of Brain Tumors

Daniela F. Quail et al.

CANCER CELL (2017)

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Review Pharmacology & Pharmacy

Radiation effects on the tumor microenvironment: Implications for nanomedicine delivery

Shawn Stapleton et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Article Nanoscience & Nanotechnology

Tailoring Particle Size of Mesoporous Silica Nanosystem To Antagonize Glioblastoma and Overcome Blood-Brain Barrier

Jianbin Mo et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Environmental Sciences

Toxicity of different forms of graphene in a chicken embryo model

Maciej Szmidt et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Effects of GSM modulated radio-frequency electromagnetic radiation on permeability of blood-brain barrier in male & female rats

Bahriye Sirav et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2016)

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Review Pharmacology & Pharmacy

Progress and perspectives on targeting nanoparticles for brain drug delivery

Huile Gao

ACTA PHARMACEUTICA SINICA B (2016)

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Review Medicine, Research & Experimental

Junctional proteins of the blood-brain barrier: New insights into function and dysfunction

Svetlana M. Stamatovic et al.

TISSUE BARRIERS (2016)

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Article Medicine, Research & Experimental

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Konrad Gabrusiewicz et al.

JCI INSIGHT (2016)

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Review Pharmacology & Pharmacy

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment

O. van Tellingen et al.

DRUG RESISTANCE UPDATES (2015)

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Review Cell Biology

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

Silvia Tietz et al.

JOURNAL OF CELL BIOLOGY (2015)

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Article Biotechnology & Applied Microbiology

Gene delivery by a cationic and thermosensitive nanogel promoted established tumor growth inhibition

Peng Cao et al.

NANOMEDICINE (2015)

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Article Chemistry, Multidisciplinary

Combined Delivery of Temozolomide and Anti-miR221 PNA Using Mesoporous Silica Nanoparticles Induces Apoptosis in Resistant Glioma Cells

Alessandro Bertucci et al.

SMALL (2015)

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Article Nanoscience & Nanotechnology

VEGF121-Conjugated Mesoporous Silica Nanoparticle: A Tumor Targeted Drug Delivery System

Shreya Goel et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Article Chemistry, Multidisciplinary

DNA-Hybrid-Gated Multifunctional Mesoporous Silica Nanocarriers for Dual-Targeted and MicroRNA-Responsive Controlled Drug Delivery**

Penghui Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Article Engineering, Biomedical

The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration

Hejiang Zhou et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

A systems toxicology approach to the surface functionality control of graphene-cell interactions

Nivedita Chatterjee et al.

BIOMATERIALS (2014)

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Review Oncology

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

Michael Weller et al.

LANCET ONCOLOGY (2014)

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Review Chemistry, Multidisciplinary

Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review

Ping Ma et al.

NANO TODAY (2013)

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Review Neurosciences

Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

Wei-Ye Liu et al.

CNS NEUROSCIENCE & THERAPEUTICS (2012)

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Article Biochemical Research Methods

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

Ross Booth et al.

LAB ON A CHIP (2012)

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Review Pharmacology & Pharmacy

Cell-mediated drug delivery

Elena V. Batrakova et al.

EXPERT OPINION ON DRUG DELIVERY (2011)

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Article Chemistry, Multidisciplinary

Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung

Matthew C. Duch et al.

NANO LETTERS (2011)

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Article Biochemical Research Methods

An endothelial and astrocyte co-culture model of the blood-brain barrier utilizing an ultra-thin, nanofabricated silicon nitride membrane

SH Ma et al.

LAB ON A CHIP (2005)

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Review Pharmacology & Pharmacy

Tight junctions of the blood-brain barrier: Development, composition and regulation

H Wolburg et al.

VASCULAR PHARMACOLOGY (2002)

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