Visible-Light-Driven NO Release from Postmodified MOFs via Photoinduced Electron Transfer for Antibacterial Application

Photoresponsive nitric oxide (NO)-releasing materials (NORMs) enable the spatiotemporal delivery of NO to facilitate their potential applications in physiological conditions. Here two novel metal-organic frameworks (MOFs)-based photoactive NORMs achieved by the incorporation of prefunctionalized NO donors into the photosensitive Fe-MOFs via a postmodification strategy is reported. The modified Fe-MOFs display superior photoactivity of NO release when exposed to visible light (up to 720 nm). Significantly, the visible-light-driven NO release properties are further corroborated by their efficient antibacterial performance. Two novel metal-organic frameworks-based photoactive nitric oxide (NO)-releasing materials, NNO@MIL-88B and NNO@NH2-MIL-88B, are prepared. The NO release from NNO@MIL-88B is activated through a photoinduced electron transfer process.image

Automated summary

This article reports the preparation of two novel metal-organic frameworks-based photoactive nitric oxide (NO)-releasing materials by incorporating prefunctionalized NO donors into the photosensitive Fe-MOFs via a postmodification strategy. The modified Fe-MOFs exhibit superior photoactivity of NO release under visible light (up to 720 nm). The visible-light-driven NO release properties are further confirmed by their efficient antibacterial performance.