Journal
SMALL
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202301377
Keywords
adoptive cell therapy; gold nanoparticles; photothermal therapy; T cells
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Cancer immunotherapy has shown limited effectiveness as a monotherapy, but this study demonstrates the potential of combining it with photothermal therapy to achieve better outcomes. By loading smart gold nanoparticles into T cells and using their photothermal effects, a higher percentage of the nanoparticles are delivered to tumor tissues, enhancing the anti-tumor activity. When the T cells no longer control tumor growth, photothermal therapy is performed to further eliminate tumors, resulting in significantly greater therapeutic efficacy compared to monotherapy.
Cancer immunotherapy is a promising therapy to treat cancer patients with minimal toxicity, but only a small fraction of patients responded to it as a monotherapy. In this study, a strategy to boost therapeutic efficacy by combining an immunotherapy based on ex vivo expanded tumor-reactive T cells is devised, or adoptive cell therapy (ACT), with photothermal therapy (PTT). Smart gold nanoparticles (sAuNPs), which aggregates to form gold nanoclusters in the cells, are loaded into T cells, and their photothermal effects within T cells are confirmed. When transferred into tumor-bearing mice, large number of sAuNP-carrying T cells successfully infiltrate into tumor tissues and exert anti-tumor activity to suspend tumor growth, but over time tumor cells evade and regrow. Of note, & AP;20% of injected doses of sAuNPs are deposited in tumor tissues, suggesting T cells are an efficient nanoparticle tumor delivery vehicle. When T cells no longer control tumor growth, PTT is performed to further eliminate tumors. In this manner, ACT and PTT are temporally coupled, and the combined immuno-photothermal treatment demonstrated significantly greater therapeutic efficacy than the monotherapy.
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