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SEXUAL DEVELOPMENT
Volume -, Issue -, Pages -Publisher
KARGER
DOI: 10.1159/000531019
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The nematode Caenorhabiditis elegans is a valuable model for studying metazoan biology due to its transparent body, invariant cell lineage, ease of genetic manipulation, and genetic conservation with higher eukaryotes. Its well annotated germline allows real-time observation of all aspects of oogenesis within a single animal, making it an outstanding model for exploring each feature of oogenesis. This review focuses on the key features that make C. elegans an exceptional model for studying germ line function and germ cell maturation.
The nematode, Caenorhabiditis elegans has proven itself as a valuable model for investigating metazoan biology. Key features including a transparent body, an invariant cell lineage, ease of genetic manipulation, coupled with a high level of genetic conservation with higher eukaryotes make C. elegans a desierable model organism. Although used to elucidate many aspects of somatic biology, a distinct advantage of C. elegans is its well annotated germline which allows all aspects of oogenesis to be observed in real-time within a single animal. C. elegans hermaphrodites have two large germlines which produce their own sperm that is later stored to fertilize their own oocytes. These two germlines take up much of the internal space of each animal and therefore, germ cells are the most abundant cell present within each animal. This feature has allowed many novel findings that established early understanding of germ cell dynamics, as well as key features of meiosis and germ cell maturation to be unveiled. This review will focus on the key features that make C. elegans an outstanding model for exploring each feature of oogenesis. This will include the fundamental steps associated with germ line function and germ cell maturation and will be of use for those interested in exploring reproductive metazoan biology.
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