4.7 Article

pH-Triggered mitochondria targeting fluorescent probe for detecting Monoamine Oxidases A in living cells

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Fluorescent probes for the detection of chemical warfare agents

Wen-Qi Meng et al.

Summary: Chemical warfare agents (CWAs) are targeted toxic chemicals that pose serious threats to public health and global peace. Accurate detection methods for CWAs are essential for security measures. Small molecule fluorescent probes have emerged as attractive tools for CWA detection due to their simplicity, selectivity, and sensitivity, and their ability to be translated into handheld devices.

CHEMICAL SOCIETY REVIEWS (2023)

Review Chemistry, Multidisciplinary

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Haidong Li et al.

Summary: The discovery of hemicyanine dyes as near-infrared fluorescent chromophores has significant implications in detection, bioimaging, and medical therapeutic applications. These dyes possess superior optical properties and structural tailorability, making them promising tools for monitoring biomolecules and diagnosing diseases.

CHEMICAL SOCIETY REVIEWS (2022)

Review Chemistry, Multidisciplinary

Activatable fluorescent probes for in situ imaging of enzymes

Xiaofeng Wu et al.

Summary: This article summarizes the methods for in situ imaging of enzymes using activatable fluorescent probes, and proposes that fluorescent probes with both activatable and in situ properties will facilitate high-resolution studies of enzymes in living systems.

CHEMICAL SOCIETY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift

Xinming Li et al.

Summary: This study successfully developed two fluorescent turn-on probes (KXS-M1 and KXS-M2) for the highly selective and sensitive detection of monoamine oxidase A (MAO-A). Among them, KXS-M2 exhibited better fluorescence increment and sensitivity, and can be used for the diagnosis and treatment of heart failure.

CHINESE CHEMICAL LETTERS (2022)

Article Chemistry, Analytical

Mitochondria targeting fluorescent probe for MAO-A and the application in the development of drug candidate for neuroinflammation

Jiarong Wu et al.

Summary: In this study, a novel Mito-targeting tool HCCP was developed for real-time imaging and detection of MAO-A activity. A high-throughput screening platform was established using HCCP to evaluate the inhibitory effects of various herbal medicines on MAO-A, leading to the discovery of a novel MAO-A inhibitor Evocarpine. This study provides an efficient method for exploring the physiological functions of MAO-A and developing potential inhibitors.

ANALYTICA CHIMICA ACTA (2022)

Review Chemistry, Multidisciplinary

Recent advances in small-molecule fluorescent probes for studying ferroptosis

Ya-Lin Qi et al.

Summary: Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death involved in the development and progression of various diseases. Small-molecule fluorescent probes have been used to study ferroptosis by tracking biomolecules or microenvironment-related parameters in vitro and in vivo.

CHEMICAL SOCIETY REVIEWS (2022)

Review Cell Biology

Monoamine oxidases in age-associated diseases: New perspectives for old enzymes

Yohan Santin et al.

Summary: Population aging leads to a higher prevalence of chronic diseases and rising healthcare costs. Cellular senescence and mitochondrial oxidative stress are key processes in age-related diseases. Monoamine oxidases (MAOs) play a role in pathological aging by being upregulated in aged or dysfunctional organs, contributing to the increased degradation of MAO substrates.

AGEING RESEARCH REVIEWS (2021)

Article Chemistry, Analytical

Water-Soluble Near-Infrared Fluorescent Probes for Specific Detection of Monoamine Oxidase A in Living Biosystems

Jizhen Shang et al.

Summary: The development of two new NIR fluorescent probes, Rma-1 and Rma-2, shows great potential for specific analysis of MAO-A in living biosystems. Among them, probe Rma-1, with a self-immolative linker, demonstrates superior analytical performance and successful imaging of MAO-A activity in cancer.

ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang et al.

Summary: The study introduces a series of MAO-A specific fluorescent probes and demonstrates the selective imaging of endogenous MAO-A activity in different biological samples using these probes, offering new tools for visual detection of glioma.

CHEMICAL COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Rational Design of a Two-Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues

Haixiao Fang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Biochemistry & Molecular Biology

Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels

Paolo Severino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

Synthetic ratiometric fluorescent probes for detection of ions

Sang-Hyun Park et al.

CHEMICAL SOCIETY REVIEWS (2020)

Article Neurosciences

Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications

Matthew A. Churchward et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Chemistry, Multidisciplinary

A Multifunctional Chemical Probe for the Measurement of Local Micropolarity and Microviscosity in Mitochondria

Arturo Jimenez-Sanchez et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Pharmacology & Pharmacy

Effect of monoamine oxidase inhibitors on ischaemia/reperfusion-induced acute kidney injury in rats

Hidenobu Tsutsui et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Review Chemistry, Multidisciplinary

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Hong-Wen Liu et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Multidisciplinary

A Strategy for Specific Fluorescence Imaging of Monoamine OxidaseA in Living Cells

Xiaofeng Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Chemistry, Multidisciplinary

Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes

Xiaohua Li et al.

CHEMICAL REVIEWS (2014)

Article Medicine, Research & Experimental

Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis

Jason Boyang Wu et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Clinical Neurology

Transcriptional regulation and multiple functions of MAO genes

Jean C. Shih et al.

JOURNAL OF NEURAL TRANSMISSION (2011)

Article Chemistry, Multidisciplinary

Design of Chemical Shift-Switching 19F Magnetic Resonance Imaging Probe for Specific Detection of Human Monoamine Oxidase A

Koya Yamaguchi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Oncology

Targeting monoamine oxidase A in advanced prostate cancer

Vincent Flamand et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

Review Cell Biology

Sensors and regulators of intracellular pH

Joseph R. Casey et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Neurosciences

The therapeutic potential of monoamine oxidase inhibitors

MBH Youdim et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Chemistry, Multidisciplinary

New bioluminogenic substrates for monoamine oxidase assays

WH Zhou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Review Biochemistry & Molecular Biology

Regulation of MAO-A and MAO-B gene expression

JC Shih et al.

CURRENT MEDICINAL CHEMISTRY (2004)

Article Cell Biology

Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line

Y Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2003)