4.6 Article

Excess body weight: Novel insights into its roles in obesity comorbidities

Related references

Note: Only part of the references are listed.
Editorial Material Endocrinology & Metabolism

Co-agonist therapeutics come of age for obesity

Tricia M. -M. Tan

Summary: GLP1 analogues are approved treatments for obesity, but novel therapies are needed for improved weight loss and the direct treatment of other comorbidities, such as non-alcoholic fatty liver disease. Recent research published in 2022 demonstrates that co-agonist combinations of GLP1 with other hormones offer clinically significant advancements.

NATURE REVIEWS ENDOCRINOLOGY (2023)

Article Multidisciplinary Sciences

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation

Masayuki Hata et al.

Summary: Obesity-induced reprogramming of the innate immune system can lead to neuroinflammation, proinflammatory cytokine transcription, pathological retinal angiogenesis, and neuronal degeneration associated with loss of visual function in age-related macular degeneration.

SCIENCE (2023)

Article Gastroenterology & Hepatology

Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis

Jingxuan Quek et al.

Summary: This study provides an overview of the global prevalence of NAFLD, NAFL, and NASH in overweight and obese individuals. The findings show that the prevalence of NAFLD in the overweight population is 69.99%, NAFL is 42.49%, and NASH is 33.50%. These results contribute to a better understanding of the global burden of NAFLD and support disease management in the at-risk overweight and obese population.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2023)

Review Pharmacology & Pharmacy

State of the art on the pathophysiology, diagnosis and treatment of non-alcoholic steatohepatitis (NASH)

G. Grzych et al.

Summary: NAFLD is a complication of obesity and diabetes with increasing prevalence. The causes and development of its severe form, NASH, are still poorly understood. Clinical trials are testing various pharmacological classes for NASH treatment, but no pharmaceutical treatment is currently available. Certainty diagnosis requires invasive liver biopsy, highlighting the need for better understanding of the disease's natural history and the identification of diagnostic markers using blood samples.

ANNALES PHARMACEUTIQUES FRANCAISES (2023)

Article Ethnic Studies

The joint association of cardiometabolic health and weight on mortality in the multiethnic cohort

Brook E. Harmon et al.

Summary: This study explores the associations between cardiometabolic-weight categories and mortality from cardiovascular disease (CVD), cancer, and all causes. The results show that metabolically unhealthy groups exhibit a higher risk of death from all causes and CVD than metabolically healthy groups. In addition, being classified as Metabolically Healthy Obese elevates mortality risk for males and females compared to Metabolically Healthy Normal Weight. However, few associations were found with cancer mortality.

ETHNICITY & HEALTH (2022)

Article Gastroenterology & Hepatology

N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer

Shiyan Wang et al.

Summary: The study identified a novel oncogenic epitranscriptome axis of YTHDF1-m(6)A-ARHGEF2 that regulates CRC tumorigenesis and metastasis.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance

Laura Krieg et al.

Summary: The study compared different fat depots in 70 obese patients undergoing Roux-en-Y gastric bypass surgery, revealing significant differences in metabolism and inflammatory pathways, with epiploic fat tissue showing the highest gene expression levels.
Review Immunology

Inflammation in obesity, diabetes, and related disorders

Theresa Rohm et al.

Summary: Obesity can cause chronic systemic inflammation, leading to insulin resistance, beta-cell dysfunction, and ultimately type 2 diabetes. This inflammatory state also contributes to long-term complications of diabetes and may be associated with other conditions like Alzheimer's disease and polycystic ovarian syndrome.

IMMUNITY (2022)

Article Medicine, General & Internal

Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes The STEP 8 Randomized Clinical Trial

Domenica M. Rubino et al.

Summary: In overweight or obese adults without diabetes, once-weekly subcutaneous semaglutide resulted in significantly greater weight loss compared to once-daily subcutaneous liraglutide when added to counseling for diet and physical activity over 68 weeks.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Review Gastroenterology & Hepatology

Diet and gut microbiome in fatty liver and its associated liver cancer

Yasi Pan et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, with the gut microbiome and dietary components playing important roles in its development and its related hepatocellular carcinoma (HCC). Components in the diet such as cholesterol, fiber, fat, and sugar can alter the gut microbiome composition, consequently affecting the progression of NAFLD and related conditions.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Medicine, General & Internal

Reassessing Human Adipose Tissue

Aaron M. Cypess

Summary: This review reevaluates human adipose tissue, discussing its roles in obesity and its important complementary functions in the endocrine system.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Endocrinology & Metabolism

Proteome-wide associations with short- and long-term weight loss and regain after Roux-en-Y gastric bypass surgery

Noha A. Yousri et al.

Summary: The study showed that most short-term postsurgical changes in proteins were maintained at 12 years. Systemic protection pathways, including inflammation, complement, lipid, and adipocyte pathways, were related to the long-term benefits of gastric bypass surgery.

OBESITY (2022)

Review Endocrinology & Metabolism

Long-acting amylin analogues for the management of obesity

David S. Mathiesen et al.

Summary: Long-acting amylin analogues have emerged as a potential pharmacotherapy for the treatment of obesity, with preclinical and early-stage clinical studies showing beneficial effects on body weight in obese individuals.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2022)

Article Multidisciplinary Sciences

A single-cell atlas of human and mouse white adipose tissue

Margo P. Emont et al.

Summary: White adipose tissue, once considered bland, is now seen as dynamic, plastic and involved in various biological processes. High-fat feeding and other metabolic stressors lead to significant changes in adipose tissue, linked to insulin resistance, dyslipidemia and type 2 diabetes. Research provides detailed cellular atlases of human and mouse adipose tissue, highlighting interactions between different cell types in lean and obese states.

NATURE (2022)

Editorial Material Endocrinology & Metabolism

PDL1 reduces adipose inflammation in obesity

Olivia Tysoe

NATURE REVIEWS ENDOCRINOLOGY (2022)

Article Cell Biology

Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity

Christian Schwartz et al.

Summary: Obesity is a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis. A recent study found that the costimulatory molecule programmed death-ligand 1 (PD-L1) plays a role in limiting diet-induced obesity. PD-L1 expression on dendritic cells (DCs) is essential for obesity control.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Nanoscience & Nanotechnology

Selective targeting of visceral adiposity by polycation nanomedicine

Qianfen Wan et al.

Summary: This research develops a nanomedicine based on polycation, which targets visceral fat selectively, preventing obesity and alleviating metabolic dysfunctions. By modulating nutrient-sensing signalling pathways, the polycation uncouples lipid synthesis and storage from adipocyte development, resulting in adipocytes with normal functions but deficient in hypertrophic growth. The study suggests the potential of cationic nanomaterials in treating metabolic diseases.

NATURE NANOTECHNOLOGY (2022)

Article Multidisciplinary Sciences

GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages

Jing Yan et al.

Summary: This study reveals that GPSM1 is genetically associated with T2D and obesity. The authors demonstrate that myeloid GPSM1 promotes metabolic inflammation and accelerates T2D and obesity development. They also identify a small molecule compound that inhibits GPSM1 function, potentially making it a candidate for metabolic therapy.

NATURE COMMUNICATIONS (2022)

Article Gastroenterology & Hepatology

METTL3 Inhibits Antitumor Immunity by Targeting m6A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer

Huarong Chen et al.

Summary: This study identifies METTL3 as a potential therapeutic target for CRC immunotherapy. Silencing or inhibiting METTL3 reduces MDSC accumulation, sustains activation and proliferation of CD4(+) and CD8(+) T cells, and ultimately suppresses CRC development. Inhibition of METTL3 plus anti-PD1 treatment shows promising antitumor efficacy against CRC.

GASTROENTEROLOGY (2022)

Article Multidisciplinary Sciences

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

Birte Niemann et al.

Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.

NATURE (2022)

Article Multidisciplinary Sciences

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

Saaket Agrawal et al.

Nature Communications (2022)

Article Biochemistry & Molecular Biology

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

W. Timothy Garvey et al.

Summary: Results from the STEP 5 trial show that semaglutide treatment leads to significant and sustained weight loss over 104 weeks compared to placebo, with more participants achieving a weight loss of >= 5% in the semaglutide group.

NATURE MEDICINE (2022)

Article Multidisciplinary Sciences

Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity

David Bradley et al.

Summary: This study found that the number of regulatory T cells in adipose tissue is reduced in obese individuals, which is associated with reduced insulin sensitivity and altered adipocyte metabolic gene expression. The number of regulatory T cells also decreases in lean individuals following induction of a high-fat diet. Interferon gamma plays a role in reducing the number and function of regulatory T cells in the adipose tissue of obese individuals, leading to adipose inflammation and insulin resistance.

NATURE COMMUNICATIONS (2022)

Article Immunology

Tregs in visceral adipose tissue up-regulate circadianclock expression to promote fitness and enforce a diurnal rhythm of lipolysis

Tianli Xiao et al.

Summary: This study reveals the diurnal regulation of regulatory T cells (T-regs) in nonlymphoid organs and identifies the importance of the cell-intrinsic clock program. BMAL1 deficiency in T-regs leads to impaired function and fitness, as well as disrupted adipose tissue lipolysis.

SCIENCE IMMUNOLOGY (2022)

Article Cell Biology

A purinergic call to arms from dying brown adipocytes

Mohammed K. Hankir

Summary: Brown adipocytes respond to temperature and nutrition challenges by increasing metabolism and generating heat. However, this response is impaired in obesity and aging. Researchers found that brown adipocytes undergo apoptosis and release ATP under thermoneutral conditions, which in turn stimulates thermogenesis and promotes metabolic health.

CELL STRESS (2022)

Article Nutrition & Dietetics

Prognostic role of visceral fat for overall survival in metastatic colorectal cancer: A pilot study

Debora Basile et al.

Summary: This study investigated the prognostic role of adiposity, especially visceral fat, in patients with metastatic colorectal cancer. The results showed that higher visceral fat values were associated with worse outcomes in these patients. Further research is needed to explore the impact of visceral fat on colorectal cancer patients.

CLINICAL NUTRITION (2021)

Article Gastroenterology & Hepatology

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al.

Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.
Article Sport Sciences

Exercise training-induced visceral fat loss in obese women: The role of training intensity and modality

Haifeng Zhang et al.

Summary: This study compared the effects of four-cycle ergometer training regimens with different exercise intensity and modality on visceral fat loss. The findings showed that all-out sprint interval training, supramaximal SIT, and high-intensity interval training led to greater reductions in abdominal visceral fat area compared to moderate-intensity continuous training.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2021)

Review Biochemistry & Molecular Biology

m6A RNA methylation: from mechanisms to therapeutic potential

P. Cody He et al.

Summary: m(6)A, the most prevalent mRNA modification, regulates gene expression by influencing mRNA metabolism in various physiological and pathophysiological processes. It plays a multifaceted role in mRNA decay, translation, and transcription, highlighting its crucial importance in post-transcriptional gene expression regulation.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation

Ruifan Wu et al.

Summary: Research has shown that m6A can regulate the browning and thermogenesis of white adipocytes by affecting the expression of HIF1A protein, thereby preventing obesity induced by a high-fat diet. This provides a new potential target for combating obesity and metabolic diseases.

EMBO REPORTS (2021)

Article Pharmacology & Pharmacy

Setmelanotide: First Approval

Anthony Markham

Summary: Setmelanotide, a melanocortin-4 (MC4) receptor agonist, has been approved in the USA for treating obesity caused by POMC, PCSK1, and LEPR deficiency. It is also being developed for other rare genetic disorders associated with obesity.

DRUGS (2021)

Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Surgery

Improvement of glucose metabolism following rapid weight loss after bariatric surgery and its impact on reduction of visceral abdominal fat versus free fat muscle

Vicente J. Cogollo et al.

Summary: This study examined the relationship between visceral abdominal fat (VAF) and fat free mass (FFM) with improved glucose metabolism after bariatric surgery. The results showed a decrease in VAF and HbA1C at the 12-month follow-up without significant loss of FFM. Further prospective studies are needed to better understand these findings.

SURGERY FOR OBESITY AND RELATED DISEASES (2021)

Article Multidisciplinary Sciences

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression

Xinzhi Li et al.

Summary: The study reveals that METTL3 negatively regulates NASH progression by inhibiting transcription of Cd36 and Ccl2 genes, playing a key role in the transition from NAFL to NASH.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.
Article Cardiac & Cardiovascular Systems

Obesity, Adipose Tissue and Vascular Dysfunction

Mascha Koenen et al.

Summary: Cardiovascular diseases, as the leading cause of death worldwide, are strongly associated with overweight and obesity, which contribute to vascular dysfunction and cardiovascular diseases. The abnormal remodeling of specific adipose tissue depots during obesity plays a critical role in the development of hypertension, endothelial dysfunction, and vascular stiffness, with fat distribution being a key determinant of the risk for cardiovascular diseases.

CIRCULATION RESEARCH (2021)

Article Immunology

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Andrew D. Hildreth et al.

Summary: This study provides a comprehensive analysis of the cellular composition in healthy and obese human white adipose tissue, revealing changes in immune cell populations and inflammatory pathways in obese individuals. The findings highlight the importance of immune cell regulation in metabolic diseases and offer insights into new cellular networks and differentiation trajectories in white adipose tissue.

NATURE IMMUNOLOGY (2021)

Review Gastroenterology & Hepatology

The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments

Giovanni Targher et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) have a complex relationship with each other, influencing the risk of adverse clinical outcomes. The severity of NAFLD is directly related to the risk of developing T2DM, while improvement of NAFLD may lower the risk of T2DM.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Medicine, General & Internal

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Philip N. Newsome et al.

Summary: This phase 2 trial demonstrated that treatment with semaglutide resulted in a significantly higher percentage of patients with NASH resolution compared to placebo in patients with NASH, but did not show a significant between-group difference in the percentage of patients with an improvement in fibrosis stage.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Pharmacology & Pharmacy

Emerging glucagon-like peptide 1 receptor agonists for the treatment of obesity

Mathies M. Jepsen et al.

Summary: Obesity is a serious public health threat, with over 1.1 billion individuals projected to have obesity in 2030 if current trends continue. There is a strong interest in developing obesity treatments based on GLP-1 agonism, with many novel compounds in clinical development aiming to target the GLP-1 receptor or other hormonal systems involved in energy balance and metabolism. Semaglutide is the most advanced compound in clinical development and may become a benchmark for novel anti-obesity compounds utilizing GLP-1 receptor agonism.

EXPERT OPINION ON EMERGING DRUGS (2021)

Article Multidisciplinary Sciences

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

Nicholas J. Carruthers et al.

Summary: Dysfunctional visceral adipose tissue in obesity is associated with type 2 diabetes, with downregulation of proteins related to fatty acid synthesis and mitochondrial function in diabetes, while upregulation of proteins associated with innate immunity and transcriptional regulation. Transcriptome analysis indicated defects in innate inflammation, lipid metabolism, and extracellular matrix function. Shared biological processes impacted by diabetes include complement activation, cell proliferation and migration, ECM organization, lipid metabolism, and gluconeogenesis. The study reveals potential mechanisms of VAT dysfunction in diabetes.

SCIENTIFIC REPORTS (2021)

Article Endocrinology & Metabolism

Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial

Ian J. Neeland et al.

Summary: In adults with overweight or obesity at high cardiovascular disease risk, once-daily liraglutide 3.0 mg plus lifestyle intervention significantly lowered visceral adipose tissue over 40 weeks of treatment, potentially explaining the cardiovascular benefits seen in previous trials among patients with type 2 diabetes.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Obesity: Epidemiology, Pathophysiology, and Therapeutics

Xihua Lin et al.

Summary: Obesity is a complex multifactorial disease with negative health effects, mainly caused by an energy imbalance. Treatment strategies should focus on biological mechanisms and reducing BMI.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Cell Biology

Cellular mechanisms linking cancers to obesity

Xiao-Zheng Liu et al.

Summary: Obesity is epidemiologically linked to 13 forms of cancer, affecting tumors through multiple avenues. Understanding the molecular mechanisms linking obesity and cancer may lead to targeted therapy for obese cancer patients.

CELL STRESS (2021)

Article Gastroenterology & Hepatology

Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly

Teresa Tavella et al.

Summary: The study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles, and cardio-metabolic risk factors.

GUT MICROBES (2021)

Review Oncology

Impact of adiposity on staging and prognosis of colorectal cancer

Ana Silva et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Association between coronary atherosclerosis and visceral adiposity index

Zsolt Bagyura et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

Article Multidisciplinary Sciences

O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity

Yunfan Yang et al.

NATURE COMMUNICATIONS (2020)

Review Endocrinology & Metabolism

Comprehensive Review of Current and Upcoming Anti-Obesity Drugs

Jang Won Son et al.

DIABETES & METABOLISM JOURNAL (2020)

Review Medicine, Research & Experimental

Type II diabetes mellitus: a review on recent drug based therapeutics

Santwana Padhi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Endocrinology & Metabolism

The epidemiology of obesity

Yu Chung Chooi et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

Article Endocrinology & Metabolism

Unlike calorie restriction, Roux-en-Y gastric bypass surgery does not increase hypothalamic AgRP and NPY in mice on a high-fat diet

Presheet P. Patkar et al.

INTERNATIONAL JOURNAL OF OBESITY (2019)

Article Gastroenterology & Hepatology

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

Xiang Zhang et al.

JOURNAL OF HEPATOLOGY (2019)

Review Cell Biology

Epigenetics in Human Obesity and Type 2 Diabetes

Charlotte Ling et al.

CELL METABOLISM (2019)

Article Medicine, General & Internal

Liraglutide in Children and Adolescents with Type 2 Diabetes

William V. Tamborlane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Gastroenterology & Hepatology

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

Sunny H. Wong et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review

Judith Gebauer et al.

ENDOCRINE REVIEWS (2019)

Review Endocrinology & Metabolism

Obesity and cancer risk: Emerging biological mechanisms and perspectives

Konstantinos Avgerinos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

Review Endocrinology & Metabolism

Oral Semaglutide In The Management Of Type 2 Diabetes: A Report On The Evidence To Date

Sam Pearson et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2019)

Article Medicine, General & Internal

The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction

Hyun Uk Moon et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2019)

Review Endocrinology & Metabolism

Microbial regulation of organismal energy homeostasis

Patrice D. Cani et al.

NATURE METABOLISM (2019)

Review Gastroenterology & Hepatology

Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017Part 1: Definition, risk factors and assessment

Vincent Wai-Sun Wong et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2018)

Review Endocrinology & Metabolism

How to best assess abdominal obesity

Hongjuan Fang et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2018)

Article Medicine, General & Internal

Maintenance of Lost Weight and Long-Term Management of Obesity

Kevin D. Hall et al.

MEDICAL CLINICS OF NORTH AMERICA (2018)

Review Cardiac & Cardiovascular Systems

Overview of Epidemiology and Contribution of Obesity and Body Fat Distribution to Cardiovascular Disease: An Update

Marie-Eve Piche et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2018)

Article Multidisciplinary Sciences

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Liping Zhao et al.

SCIENCE (2018)

Article Surgery

Resting energy expenditure after Roux-en Y gastric bypass surgery

Britta Wilms et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2018)

Editorial Material Endocrinology & Metabolism

Precision medicine: diagnosis and management of obesity

Gema Fruhbeck et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Oncology

Obesity is Independently Associated With Increased Risk of Hepatocellular Cancer-related Mortality A Systematic Review and Meta-Analysis

Arjun Gupta et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2018)

Article Endocrinology & Metabolism

Relation between adiposity and vascular events, malignancy and mortality in patients with stable cerebrovascular disease

N. E. M. Jaspers et al.

INTERNATIONAL JOURNAL OF OBESITY (2017)

Article Cardiac & Cardiovascular Systems

Visceral adiposity index and 10-year cardiovascular disease incidence: The ATTICA study

G. -M. Kouli et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2017)

Review Medicine, General & Internal

Adiposity and cancer at major anatomical sites: umbrella review of the literature

Maria Kyrgiou et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

Review Medicine, General & Internal

Adiposity and cancer at major anatomical sites: umbrella review of the literature

Maria Kyrgiou et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

Article Medicine, General & Internal

Effect of tadalafil administration on insulin secretion and insulin sensitivity in obese men

Manuel Gonzalez-Ortiz et al.

ACTA CLINICA BELGICA (2017)

Article Multidisciplinary Sciences

Body Fat Distribution and the Risk of Incident Metabolic Syndrome: A Longitudinal Cohort Study

Hyuktae Kwon et al.

SCIENTIFIC REPORTS (2017)

Article Endocrinology & Metabolism

Weight Loss and Improvement in Comorbidity: Differences at 5%, 10%, 15%, and Over

Donna H. Ryan et al.

CURRENT OBESITY REPORTS (2017)

Review Oncology

Morbidity and mortality associated with obesity

Mahmoud Abdelaal et al.

ANNALS OF TRANSLATIONAL MEDICINE (2017)

Article Chemistry, Medicinal

Inhaled PYY(3-36) dry-powder formulation for appetite suppression

Philip J. Kuehl et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2016)

Article Cardiac & Cardiovascular Systems

Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications

Shilpa N. Bhupathiraju et al.

CIRCULATION RESEARCH (2016)

Article Medicine, General & Internal

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Pharmacology & Pharmacy

Prevalence and prevention of cardiovascular disease and diabetes mellitus

Pitchai Balakumar et al.

PHARMACOLOGICAL RESEARCH (2016)

Review Endocrinology & Metabolism

Adipose Tissue Remodeling: its Role in energy Metabolism and Metabolic Disorders

Sung Sik Choe et al.

FRONTIERS IN ENDOCRINOLOGY (2016)

Review Surgery

Worldwide burden of colorectal cancer: a review

Pasqualino Favoriti et al.

UPDATES IN SURGERY (2016)

Article Medicine, Research & Experimental

Metabolically normal obese people are protected from adverse effects following weight gain

Elisa Fabbrini et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Gastroenterology & Hepatology

Visceral Obesity Predicts Fewer Lymph Node Metastases and Better Overall Survival in Colon Cancer

Se Woo Park et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2015)

Article Biochemistry & Molecular Biology

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

Nicolas Suarez-Zamorano et al.

NATURE MEDICINE (2015)

Article Surgery

Effects of a very low calorie diet in the preoperative stage of bariatric surgery: a randomized trial

Silvia Leite Faria et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2015)

Article Multidisciplinary Sciences

Gut mucosal microbiome across stages of colorectal carcinogenesis

Geicho Nakatsu et al.

NATURE COMMUNICATIONS (2015)

Editorial Material Oncology

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

FRONTIERS OF MEDICINE (2015)

Review Endocrinology & Metabolism

Epigenetics and human obesity

S. J. van Dijk et al.

INTERNATIONAL JOURNAL OF OBESITY (2015)

Article Gastroenterology & Hepatology

The impact of visceral obesity on surgical outcomes of laparoscopic surgery for colon cancer

Jun Watanabe et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2014)

Article Biochemical Research Methods

A Protein Profile of Visceral Adipose Tissues Linked to Early Pathogenesis of Type 2 Diabetes Mellitus

Su-Jin Kim et al.

MOLECULAR & CELLULAR PROTEOMICS (2014)

Article Gastroenterology & Hepatology

Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression

Silvia Riondino et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Biotechnology & Applied Microbiology

Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application

Xue Sun et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Immunology

Chronic Inflammation and Cytokines in the Tumor Microenvironment

Glauben Landskron et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

Body Fat Distribution, Incident Cardiovascular Disease, Cancer, and All-Cause Mortality

Kathryn A. Britton et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Article Multidisciplinary Sciences

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura et al.

SCIENCE (2013)

Article Cell Biology

Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity

Alice P. Liou et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Review Oncology

Obesity, insulin resistance, NASH and hepatocellular carcinoma

Jun Yu et al.

SEMINARS IN CANCER BIOLOGY (2013)

Review Nutrition & Dietetics

Body Fat Distribution and Insulin Resistance

Pavankumar Patel et al.

NUTRIENTS (2013)

Review Radiology, Nuclear Medicine & Medical Imaging

The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis

A. Shuster et al.

BRITISH JOURNAL OF RADIOLOGY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans

B. J. Klopfenstein et al.

BRITISH JOURNAL OF RADIOLOGY (2012)

Article Surgery

Body composition and outcome in patients undergoing resection of colorectal liver metastases

M. G. van Vledder et al.

BRITISH JOURNAL OF SURGERY (2012)

Article Cardiac & Cardiovascular Systems

Prognostic significance of the Complex Visceral Adiposity Index vs. simple anthropometric measures: Tehran lipid and glucose study

Bozorgmanesh Mohammadreza et al.

CARDIOVASCULAR DIABETOLOGY (2012)

Article Gastroenterology & Hepatology

Impact of fat obesity on laparoscopic total mesorectal excision: more reliable indicator than body mass index

Jeonghyun Kang et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2012)

Article Medicine, General & Internal

Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes

Edward W. Gregg et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Article Oncology

Visceral obesity is associated with outcomes of total mesorectal excision for rectal adenocarcinoma

Nikiforos Ballian et al.

JOURNAL OF SURGICAL ONCOLOGY (2012)

Article Multidisciplinary Sciences

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Daniela Cipolletta et al.

NATURE (2012)

Article Public, Environmental & Occupational Health

National, regional, and global trends in adult overweight and obesity prevalences

Gretchen A. Stevens et al.

POPULATION HEALTH METRICS (2012)

Review Medicine, Research & Experimental

Inflammatory links between obesity and metabolic disease

Carey N. Lumeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Gastroenterology & Hepatology

Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications

Elisa Fabbrini et al.

HEPATOLOGY (2010)

Review Surgery

Systematic review of sleeve gastrectomy as staging and primary bariatric procedure

Stacy A. Brethauer et al.

SURGERY FOR OBESITY AND RELATED DISEASES (2009)

Article Gastroenterology & Hepatology

Visceral Obesity Predicts Surgical Outcomes after Laparoscopic Colectomy for Sigmoid Colon Cancer

Shingo Tsujinaka et al.

DISEASES OF THE COLON & RECTUM (2008)

Editorial Material Surgery

An evidenced-based assessment of preoperative weight loss in bariatric surgery

Michael Tarnoff et al.

OBESITY SURGERY (2008)

Article Medicine, Research & Experimental

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Carey N. Lumeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Endocrinology & Metabolism

Metabolic Obesity: The Paradox Between Visceral and Subcutaneous Fat

Osama Hamdy et al.

CURRENT DIABETES REVIEWS (2006)

Article Medicine, General & Internal

Effect of orlistat on weight and body composition in obese adolescents - A randomized controlled trial

JP Chanoine et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Article Endocrinology & Metabolism

Impact of intra-abdominal fat and age on insulin sensitivity and β-cell function

KM Utzschneider et al.

DIABETES (2004)

Article Pharmacology & Pharmacy

Effects of orlistat on fat-soluble vitamins in obese adolescents

JR McDuffie et al.

PHARMACOTHERAPY (2002)

Article Endocrinology & Metabolism

The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study

AS Jackson et al.

INTERNATIONAL JOURNAL OF OBESITY (2002)

Article Biochemistry & Molecular Biology

Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier

AJ Kastin et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2002)

Review Pharmacology & Pharmacy

Orlistat, a new lipase inhibitor for the management of obesity

AM Heck et al.

PHARMACOTHERAPY (2000)