4.8 Article

NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

Tatsuya Hasegawa et al.

Summary: Senescent fibroblast accumulation in aging human skin is controlled by a virus-immune axis. Senescent fibroblasts increase in old skin, but not in the elderly, which is associated with increased recruitment of CXCL9 and cytotoxic CD4+ T cells. Skin-resident CD4 CTLs eliminate senescent fibroblasts expressing HLA-II and HCMV-gB through an HLA-II-dependent mechanism.
Article Biochemistry & Molecular Biology

NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes

Juan Fan et al.

Summary: This study demonstrates that NKG2D has the ability to distinguish different ligands through mechanical force, with force strengthening the binding with MICA significantly.

EMBO JOURNAL (2022)

Article Multidisciplinary Sciences

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

J. Joseph Melenhorst et al.

Summary: CAR T cells redirected to target CD19 demonstrated long-lasting potential and clonal stability in two patients with chronic lymphocytic leukaemia. Highly activated CD4(+) cells emerged and dominated the CAR T cell population at later time points. These unexpected CAR T cell populations provide novel insights into anti-cancer response and long-term remission in leukaemia.

NATURE (2022)

Review Cell Biology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco et al.

Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Strategies for late phase preclinical and early clinical trials of senolytics

Erin O. Wissler Gerdes et al.

Summary: Accumulation of senescent cells is associated with various age-related and chronic diseases, making them potential targets for intervention. Preclinical and early clinical trials with senolytics have shown promising results, but more clinical trials are needed to further evaluate their efficacy across different aging and disease models.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Article Multidisciplinary Sciences

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Mark Yarmarkovich et al.

Summary: The majority of oncogenic drivers are intracellular proteins, thus limiting immunotherapeutic targeting. However, targeting non-immunogenic intracellular oncoproteins like PHOX2B using peptide-centric CARs shows promise in expanding immunotherapeutic targets and potentially benefiting a wider range of patients by breaking conventional HLA restriction.

NATURE (2021)

Article Cell Biology

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Christopher D. Wiley et al.

Summary: Cellular senescence is a stress or damage response that leads to permanent proliferative arrest and secretion of factors with potent biological activities. Senescent cells activate the biosynthesis of oxylipins, including prostaglandins, which promote the senescence arrest and SASP by activating RAS signaling. The release of specific prostaglandins, such as 15deoxy-delta-12,14-prostaglandin J2, serves as a biomarker for senolysis in culture and in vivo.

CELL METABOLISM (2021)

Article Cell Biology

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Pingyu Liu et al.

Summary: Research shows that METTL3 and METTL14 promote the senescence-associated secretory phenotype in an m(6)A-independent manner. METTL14 is redistributed to enhancers, while METTL3 is localized to pre-existing NF-kappa B sites in the promoters of SASP genes during senescence. Both are essential for SASP, but it is not regulated by m(6)A mRNA modification.

NATURE CELL BIOLOGY (2021)

Article Cell Biology

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

Masayoshi Suda et al.

Summary: The study identified GPNMB as a target for senolytic therapy, and immunization against GPNMB improved normal and pathological phenotypes associated with aging, extending the lifespan of aging mice.

NATURE AGING (2021)

Review Cell Biology

Strategies for targeting senescent cells in human disease

Nathan S. Gasek et al.

Summary: Cellular senescence is a unique cell fate that plays a role in development and wound healing, while also limiting tumor formation. However, the pathologic accumulation of senescent cells is associated with various diseases and age-related morbidities. Research shows that treatments targeting senescent cells through apoptosis induction or inhibition of senescence-related secretory phenotype are beneficial for geriatric decline and chronic diseases.

NATURE AGING (2021)

Article Oncology

Therapy-Induced Senescence Drives Bone Loss

Zhangting Yao et al.

CANCER RESEARCH (2020)

Article Multidisciplinary Sciences

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Shota Yoshida et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor et al.

NATURE (2020)

Review Cell Biology

A Senescence-Centric View of Aging Implications for Longevity and Disease

M. Borghesan et al.

TRENDS IN CELL BIOLOGY (2020)

Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Branca I. Pereira et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Targeting cardiac fibrosis with engineered T cells

Haig Aghajanian et al.

NATURE (2019)

Article Oncology

Eradication of Hepatocellular Carcinoma by NKG2D-Based CAR-T Cells

Bin Sun et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Review Medicine, Research & Experimental

Senescent cells: a therapeutic target for cardiovascular disease

Bennett G. Childs et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

Jae H. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

Review Immunology

NKG2D and Its Ligands: One for All, All for One

Alessandra Zingoni et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Non-human primates as a model for aging

Ricki J. Colman

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Biochemistry & Molecular Biology

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr et al.

NATURE MEDICINE (2017)

Review Biotechnology & Applied Microbiology

Senescent cells: an emerging target for diseases of ageing

Bennett G. Childs et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Multidisciplinary Sciences

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

Article Immunology

Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice

Marie-Louise Sentman et al.

JOURNAL OF IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

Article Oncology

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Nilgun Tasdemir et al.

CANCER DISCOVERY (2016)

Review Oncology

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

Shundong Cang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

Article Biotechnology & Applied Microbiology

T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Heather VanSeggelen et al.

MOLECULAR THERAPY (2015)

Article Multidisciplinary Sciences

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Oncology

NKG2D Receptor and Its Ligands in Host Defense

Lewis L. Lanier

CANCER IMMUNOLOGY RESEARCH (2015)

Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

Article Cell Biology

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Marco L. Davila et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Medicine, Research & Experimental

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tamara Tchkonia et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Cardiac & Cardiovascular Systems

Pulmonary Arterial Hypertension in Patients Treated by Dasatinib

David Montani et al.

CIRCULATION (2012)

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Senescence of activated stellate cells limits liver fibrosis

Valery Krizhanovsky et al.

Review Oncology

Telomere dysfunction and tumour suppression: the senescence connection

Yibin Deng et al.

NATURE REVIEWS CANCER (2008)

Article Cell Biology

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

S Parrinello et al.

NATURE CELL BIOLOGY (2003)

Review Biochemistry & Molecular Biology

Cellular senescence: Mitotic clock or culture shock?

CJ Sherr et al.