Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 892, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2023.164341
Keywords
Hair analysis; Human biomonitoring; micro -organic contaminants; Exposure assessment
Categories
Ask authors/readers for more resources
Human biomonitoring is crucial for assessing human exposure to micro-organic contaminants (MOCs) such as persistent organic pollutants and flame retardants. Hair analysis, a noninvasive method, shows promise in monitoring MOCs but its reliability in reflecting body burden is still debated. This review discusses the incorporation mechanisms of MOCs into hair, the need for standardized protocols, and the applications of hair analysis in large-scale surveys and epidemiological investigations.
Human biomonitoring has played an important role in assessing human exposure to micro-organic contaminants (MOCs), including chlorinated persistent organic pollutants, brominated flame retardants, organophosphorus flame retardants, non-persistent pesticides, per- and polyfluoroalkyl substances, phthalate esters, bisphenols, and polycyclic aromatic hydrocarbons. Specifically, human hair holds great promise as a noninvasive matrix for MOC biomonitoring. While human hair has been widely used to detect numerous MOCs over recent decades, its reliability of reflecting body burden is still disputable. As a premise for discussion, it is necessary to understand the mechanisms of MOC incorpo-ration into hair from endogenous and exogenous exposures. Then, standardized protocols must be developed to ensure accurate and reliable results. This review article discusses these issues and provides evidence for the reliability of mon-itoring MOCs in hair by surveying past reports from various categories of MOCs. We find that most persistent organic pollutants -especially those with a higher octanol-water partition coefficient and lower volatility -can be reliably mea-sured using hair analysis, while internal exposure can be accurately measured using MOC metabolites in hair. Finally, we explore the applications of hair analysis in large-scale surveys, retrospective cohort studies, and epidemiological investigations, highlighting the promise of hair analysis in studying the health risks of MOCs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available