Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth

Article Biochemistry & Molecular Biology

RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis

Pavel Moudry et al.

Summary: This study conducted a screening of 175 human ribosome biogenesis factors, revealing the crucial positive role of WDR75 in ribosome biogenesis and its impact on p53 stability checkpoint, leading to impaired proliferation and cellular senescence.

CELL DEATH AND DIFFERENTIATION (2022)

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Review Biochemistry & Molecular Biology

p53 in ferroptosis regulation: the new weapon for the old guardian

Yanqing Liu et al.

Summary: p53 plays a crucial role in tumor suppression through modulating ferroptosis, a form of iron-dependent non-apoptotic cell death. Through its metabolic targets, p53 can regulate the cellular response to ferroptosis inducers. This review also discusses the potential of targeting p53-mediated ferroptotic responses for the treatment of human cancers and other diseases.

CELL DEATH AND DIFFERENTIATION (2022)

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Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Cell Biology