Journal
SCIENCE CHINA-CHEMISTRY
Volume 66, Issue 10, Pages 2847-2851Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-023-1798-1
Keywords
diphosphine; asymmetric hydrogenation; chiral ligand
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A series of novel atropisomeric diphosphine ligands termed TanPhos with a smaller bite angle were synthesized and designed. TanPhos exhibited high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of α-dehydro amino ketones, achieving up to 99% yield and 99% ee for a wide range of chiral α-amino ketones.
A series of novel atropisomeric diphosphine ligands termed TanPhos were designed and synthesized, which has a smaller bite angle compared with that of other ligands such as BINAP. TanPhos showed high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of a-dehydro amino ketones, and up 99% yield and 99% ee were obtained for a wide range of chiral & alpha;-amino ketones.
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