Journal
SCIENCE
Volume 382, Issue 6667, Pages 171-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.adf3786
Keywords
-
Categories
Ask authors/readers for more resources
This study provides a detailed analysis of early telencephalic development in primates, revealing the molecular programs of early organizing centers and their interaction with neural stem cells (NSCs). The study also identifies regional transcriptomic variations and highlights the potential role of genes associated with neuropsychiatric disorders and brain cancer risk in early telencephalic development and NSC progression.
During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing primate-biased galanin-like peptide (GALP) signaling in the anteroventral telencephalon. Regional transcriptomic variations were observed along the frontotemporal axis during early stages of neocortical NSC progression and in neurons and astrocytes. Additionally, we found that genes associated with neuropsychiatric disorders and brain cancer risk might play critical roles in the early telencephalic organizers and during NSC progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available