Synthesis of conjugates of cobalt bis(dicarbollide) with acridine

A new 9-(azidoethylamino)acridine was obtained by the reaction of 9-methoxyacridine with N3CH2CH2NH2 & BULL; HCl by refluxing in MeCN. Boron-containing conjugates of acridine were synthesized by the CuI-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of acetylene derivatives of cobalt bis(dicarbollide) with 9-azidoacridine. The complexes obtained can be used as boron-containing DNA intercalators for boron neutron capture therapy of cancer.

Automated summary

A new azidoethylaminoacridine compound was synthesized and boron-containing acridine conjugates were obtained through a specific reaction. These compounds have potential applications as DNA intercalators for boron neutron capture therapy.