Effects of a foot-ankle muscle strengthening program on pain and function in individuals with knee osteoarthritis: a randomized controlled trial

Background: Foot-ankle exercises could improve pain and function of individuals with KOA and need to be tested.Objective: To investigate whether an 8-week foot-ankle muscle strengthening program is effective for individuals with KOA to reduce pain and improve function. Methods: In this randomized controlled trial, individuals diagnosed with clinical and radiographic KOA were randomized into the intervention (supervised foot-ankle strengthening exercise program three times a week for 8 weeks) or control (usual care and recommendations of the healthcare team) group. Effectiveness was assessed by changes in clinical and functional outcomes between baseline and 8 weeks with pain as the primary outcome. ANCOVA tests using the intervention group as a reference and sex, body mass index, and baseline values as covariates assessed between-group differences.Results: The intervention group showed lower pain scores (-4.4 units; 95%CI =-7.5,-1.1), better function (-7.1 units; 95%CI =-12.7,-1.4), higher total functional score (-11.9 units; 95%CI =-20.7,-3.1), with confidence intervals indicating a potential for the differences to be clinically meaningful, and better scores for the 30-s chair stand test (2.7 repetitions; 95%CI = 1.1, 4.1), with a confidence interval indicating a moderate clinically meaningful difference, compared to the controls. Conclusion: The 8-week foot-ankle exercise program showed positive, and potentially clinically meaningful, effects on knee pain and physical function among individuals with KOA, when com-pared to usual care. Trial registration: NCT04154059. https://clinicaltrials.gov/ct2/show/NCT04154059 (c) 2023 Associacao Brasileira de Pesquisa e Pos-Graduacao em Fisioterapia. Published by Elsevier Espana, S.L.U. All rights reserved.

Automated summary

The study suggests that an 8-week foot-ankle exercise program can reduce pain and improve physical function in individuals with knee osteoarthritis.