Journal
CHEMICAL ENGINEERING JOURNAL
Volume 279, Issue -, Pages 188-197Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2015.04.152
Keywords
Magnetic nanocapsules; N-palmitoyl chitosan; Doxorubicin; Double emulsion
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Funding
- Romanian Ministry of Education and Scientific Research, CNCS - UEFISCDI [PN-II-RU-PD-2012-3-0282]
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Doxorubicin-loaded magnetic nanocapsules, based on N-palmitoyl chitosan and magnetite, have been prepared using a double emulsion method. The morphology and size of the nanocapsules have been investigated by transmission and scanning electron microscopy. Magnetic nanocapsules were nearly spherical in shape, with a mean diameter in the nanometer range, and positive zeta potential. Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and Energy Dispersive X-ray analysis (EDX) confirmed the structure of composite magnetic nanocapsules. Magnetic nanocapsules exhibited suitable magnetic saturation, superparamagnetic behavior and good ability to incorporate a chemotherapeutic agent, properties which can be exploited in many different areas of biomedicine. (C) 2015 Elsevier B.V. All rights reserved.
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