Journal
PSYCHIATRY RESEARCH
Volume 326, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2023.115283
Keywords
Physical activity; Blood serum; Biomarkers
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This study aimed to investigate the effect of exercise on brain-derived neurotrophic factor (BDNF) levels in patients with major depressive disorder (MDD). The results showed that strenuous activity significantly increased serum BDNF levels in MDD patients.
Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).
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