Journal
MONATSHEFTE FUR CHEMIE
Volume 148, Issue 1, Pages 37-48Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-016-1879-3
Keywords
Solvent effect; Carbanions; Grignard reaction; Green chemistry
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Funding
- University of Vienna
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Since the introduction of 2-methyltetrahydrofuran as an useful alternative to the classical tetrahydrofuran, there has been a continuous interest in the synthetic community operating at academic and industrial towards it. In particular, the much higher stability that basic organometallic reagents display in 2-methyltetrahydrofuran makes it suitable for processes involving such sensitive species including asymmetric transformations. The easy formation of an azeotropic mixture with water, the substantial immiscibility with water, and the fact it derives from natural sources (corncobs or bagasse), allow to consider it in agreement with the Anastas' Geen Chemistry principles. In this minireview, selected examples of its employment in organometallic transformations ranging from carbanions to radical and transition metal-catalyzed processes are provided.
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