TopDownApp: An open and modular platform for analysis and visualisation of top-down proteomics data

Although Top-down (TD) proteomics techniques, aimed at the analysis of intact proteins and proteoforms, are becoming increasingly popular, efforts are needed at different levels to generalise their adoption. In this context, there are numerous improvements that are possible in the area of open science practices, including a greater application of the FAIR (Findable, Accessible, Interoperable, and Reusable) data principles. These include, for example, increased data sharing practices and readily available open data standards. Additionally, the field would benefit from the development of open data analysis workflows that can enable data reuse of public datasets, something that is increasingly common in other proteomics fields.

Automated summary

Although Top-down (TD) proteomics techniques are gaining popularity in intact protein and proteoform analysis, efforts are required to promote their adoption at different levels. Open science practices, including data sharing and open data analysis workflows, need to be improved and implemented.