Effect of tumor CD276 expression on infiltrating immune cells and clinicopathological features of prostate cancer

Article Oncology

Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial

Charu Aggarwal et al.

Summary: In this study, checkpoint targeting with enoblituzumab and pembrolizumab showed acceptable safety and antitumor activity in patients with CPI-naive HNSCC and NSCLC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Review Dentistry, Oral Surgery & Medicine

Mechanisms of immune evasion by head and neck cancer stem cells

Flavia Calo Aquino Xavier et al.

Summary: This review focuses on the impact of Head and Neck Cancer Stem Cells (HNCSCs) on tumor evasion through immunosuppression, CSCs phenotypes, and environmental signals. The study highlights the involvement of cell surface receptors, secreted products and ligands, crosstalk between cells, and genetic regulation in immune evasion. Understanding the interaction between HNCSCs and immune cells in the tumor microenvironment is crucial for optimizing targets and improving immune recognition in cancer treatments.

FRONTIERS IN ORAL HEALTH (2022)

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Review Immunology

The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives

Jamal Majidpoor et al.

Summary: The interaction between PD-L1 and PD-1 is crucial for immune evasion in cancers, with PD-L1 positivity generally associated with higher responses to immune checkpoint inhibition (ICI) but also poor prognosis. Triple negative breast cancer (TNBC) is aggressive, but shows meaningful responses to ICI. Combining anti-PD-1/PD-L1 with immune modulatory drugs has shown significant clinical benefits.

CLINICAL IMMUNOLOGY (2021)

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Review Urology & Nephrology