Journal
PROGRESS IN ORGANIC COATINGS
Volume 184, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.porgcoat.2023.107841
Keywords
Electrophoretic deposition; Magnesium alloy; Bioactive glasses; Composite coating; Biocompatibility
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Electrophoretic deposition was used to prepare bioactive glass-chitosan coating loaded with tetracycline on AZ31B magnesium alloy. The coating exhibited improved corrosion resistance, antibacterial activity, and osteogenic induction properties. It has potential for application in medical devices and bone implant materials.
Electrophoretic deposition (EPD) is a coating technique which is widely applied to improve the biocompatibility and anticorrosive performance of medical metal alloys. In this paper EPD was employed to deposit bioactive glasses(BGs)-chitosan(CS) coating loaded with model drug tetracycline(TCH) on AZ31B magnesium alloy to enhance its anti-inflammation, anti-bacteria, anticorrosion and osteogenic induction properties. The electro-chemical test showed that the corrosion current density of CS-BGs-1.0 TCH coating was 2 orders of magnitude lower than that of bare AZ31B. In vitro biological activity revealed that after 3 d of immersion in simulated body fluid, the surface of the coating was covered with a layer of hydroxyapatite. In vitro drug release test showed that the drug in CS-BGs-1.0 TCH could be effectively released for 504 h, providing resistance to the formation of bacterial film in a long time. In vitro antibacterial tests indicated that the coating significantly improved the antibacterial activity of magnesium alloy against E.coli. As a result, the prepared coating had better corrosion resistance, antibacterial and biological activity. This coating has good potential in the application of medical devices and bone implant materials.
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