Diverse beta burst waveform motifs characterize movement-related cortical dynamics

Classical analyses of induced, frequency-specific neural activity typically average band-limited power over trials. More recently, it has become widely appreciated that in individual trials, beta band activity occurs as transient bursts rather than amplitude-modulated oscillations. Most studies of beta bursts treat them as unitary, and having a stereotyped waveform. However, we show there is a wide diversity of burst shapes. Using a biophysical model of burst generation, we demonstrate that waveform variability is predicted by variability in the synaptic drives that generate beta bursts. We then use a novel, adaptive burst detection algorithm to identify bursts from human MEG sensor data recorded during a joystick-based reaching task, and apply principal component analysis to burst waveforms to define a set of dimensions, or motifs, that best explain waveform variance. Finally, we show that bursts with a particular range of waveform motifs, ones not fully accounted for by the biophysical model, differentially contribute to movement-related beta dynamics. Sensorimotor beta bursts are therefore not homogeneous events and likely reflect distinct computational processes.

Automated summary

Classical analyses of neural activity usually average power over trials, while recent studies have shown that beta band activity occurs in transient bursts. In this study, we demonstrate that burst shapes vary widely and are predicted by variability in synaptic drives. Burst detection algorithm and principal component analysis were then used to identify different waveform motifs and their contribution to movement-related beta dynamics. This suggests that sensorimotor beta bursts are not homogeneous events and reflect distinct computational processes.