Journal
MOLECULES AND CELLS
Volume 39, Issue 1, Pages 40-45Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.14348/molcells.2016.2327
Keywords
kinase; peroxiredoxin; phosphatase; redox; thioredoxin
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Funding
- BBSRC
- Biotechnology and Biological Sciences Research Council [1219264] Funding Source: researchfish
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Peroxiredoxins are highly conserved and abundant peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin (Prx) is important to maintain low levels of endogenous hydrogen peroxide, Prx have also been shown to promote hydrogen peroxide-mediated signalling. Mitogen activated protein kinase (MAPK) signalling pathways mediate cellular responses to a variety of stimuli, including reactive oxygen species (ROS). Here we review the evidence that Prx can act as both sensors and barriers to the activation of MAPK and discuss the underlying mechanisms involved, focusing in particular on the relationship with thioredoxin.
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