Journal
MOLECULES
Volume 21, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules21020189
Keywords
synthesis; quinazoline; sulfonamides; anticancer activity
Funding
- Deanship of Scientific Research at King Saud University [RGP-VPP-302]
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By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2-21 were synthesized using a simple and convenient method. Evaluation of these compounds against different cell lines identified compounds 7 and 17 as most active anticancer agents as they showed effectiveness on the four tested cell lines. The anticancer screening results of the tested compounds provides an encouraging framework that could lead to the development of potent new anticancer agents.
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