Journal
MOLECULES
Volume 21, Issue 9, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules21091130
Keywords
Morus alba; twigs; phenolic compounds; tyrosinase inhibition
Funding
- National Key Scientific Instrument and Equipment Development Special Fund of China [2011YQ170067]
- Natural Science Foundation of Jiangsu Province of China [BK20141110]
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The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2-17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 +/- 0.01 mu M), 2,4,2,4-tetrahydroxychalcone (IC50 0.07 +/- 0.02 mu M), morachalcone A (IC50 0.08 +/- 0.02 mu M), oxyresveratrol (IC50 0.10 +/- 0.01 mu M), and moracin M (8.00 +/- 0.22 mu M) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.
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