The recent development of silk fibroin in angiogenesis

Silk fibroin (SF) has been utilized in various applications, including as, in bone, cartilage, nerve, skin regeneration, owing to its biocompatibility, controllable biodegradability, minimal inflammation, and tunable mechanical properties. Excellent neovascularization of silk matrices is prerequisite for the success of promoting wound healing in different tissues. Neovascularization of SF can provide a nutrient supply to the newly developed granulation tissue at the wound site and accelerate vessel formation and remodeling. In this review, we summarize the neovascularization of SF in different forms and dissolution by recombining different composites, modifying active peptides, and adding growth factors in the treatment of various wound healing processes.

Automated summary

Silk fibroin (SF) is commonly used in different applications due to its biocompatibility, controllable biodegradability, minimal inflammation, and adjustable mechanical properties. Neovascularization of SF is essential for successful wound healing, as it provides nutrient supply to the granulation tissue and promotes vessel formation and remodeling. This review summarizes the neovascularization of SF in various forms and dissolutions through the use of different composites, modified active peptides, and added growth factors in the treatment of different wound healing processes.