Journal
MOLECULES
Volume 21, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules21121630
Keywords
Salvia miltiorrhiza Bge.; tanshinones; pharmacokinetics; UPLC-TQ/MS; chronic renal failure
Funding
- National Natural Science Foundation of China [81373889, 81473408, 81673533]
- program for excellent talents in school of pharmacy of Nanjing university of Chinese Medicine [15ZYXET-2]
- Construction Project for Jiangsu Key Laboratory for High Technology Research of TCM Formulae [BM2010576, BK2010561]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [ysxk-2014]
- Program for New Century Excellent Talents by the Ministry of Education [NCET-13-0873]
- 333 High-level Talents Training Project - Jiangsu Province
- Six Talents Project - Jiangsu Province [2012-YY-010]
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Salvia miltiorrhiza, one of the major traditional Chinese medicines, is commonly used and the main active ingredients-tanshinones-possess the ability to improve renal function. In this paper, the UPLC-TQ/MS method of simultaneously determining four tanshinones-tanshinone IIA, dihydrotanshinone I, tanshinone I, and cryptotanshinone-was established and applied to assess the pharmacokinetics in normal and chronic renal failure (CRF) rat plasma. The pharmacokinetics of tanshinones in rats were studied after separately intragastric administration of Salvia miltiorrhiza ethanol extract (SMEE) (0.65 g/kg), SMEE (0.65 g/kg) combined with Salvia miltiorrhiza water extract (SMWE) (1.55 g/kg). The results showed C-max and AUC(0-t) of tanshinone IIA, tanshinone I, cryptotanshinone reduced by 50%similar to 80% and CLz/F increased by 2 similar to 4 times (p < 0.05) in model group after administrated with SMEE. Nevertheless, after intragastric administration of a combination of SMWE and SMEE, the C-max and AUC(0-t) of four tanshinones were upregulated and CLz/F was downregulated, which undulated similarity from the model group to the normal group with compatibility of SMEE and SMWE. These results hinted that SMWE could improve the bioavailability of tanshinones in CRF rats, which provides scientific information for further exploration the mechanism of the combination of SMWE and SMEE and offers a reference for clinical administration of Salvia miltiorrhiza.
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