Journal
MOLECULES
Volume 21, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules21121665
Keywords
Orixa japonica; mosquito; pyrrolidine alkaloid; larvicidal activity; nematicidal activity
Funding
- National Key Technology Research and Development Program of Ministry of Science and Technology of China [2014BAD23B02]
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A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 mu g/mL), Anopheles sinensis (LC50 = 49.91 mu g/mL), and Culex pipiens pallens (LC50 = 161.10 mu g/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC50 = 391.50 mu g/mL) and Meloidogynein congnita (LC50 = 134.51 mu g/mL). The results indicate that the crude ethanol extract of O. japonica root barks and its isolated pyrrolidine alkaloid have potential for development into natural larvicides and nematicides.
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