Journal
MOLECULES
Volume 21, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules21060732
Keywords
antifungal activity; N-myristoyltransferase; benzofuran; 1,2,3-triazole; click chemistry; molecule hybrid
Funding
- National Natural Science Foundation of China [81573292]
Ask authors/readers for more resources
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against five strains of pathogenic fungi. The result indicated that the target compounds exhibited moderate to satisfactory activity. Furthermore, molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. Based on the results, preliminary structure activity relationships (SARs) were summarized to serve as a foundation for further investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available