4.6 Article

Efficacy and safety of veliparib plus chemotherapy for the treatment of lung cancer: A systematic review of clinical trials

Related references

Note: Only part of the references are listed.
Article Oncology

Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

Ramaswamy Govindan et al.

Summary: Patients with advanced non-squamous non-small cell lung cancers without oncogenic drivers did not show survival benefits from veliparib plus chemotherapy. However, a trend towards improved survival was observed in a subgroup of patients. The LP52 gene signature may be useful in identifying patients who are more likely to benefit from veliparib.

CLINICAL LUNG CANCER (2022)

Review Medicine, Research & Experimental

The regulatory role of autophagy-related miRNAs in lung cancer drug resistance

Mahshid Shahverdi et al.

Summary: Autophagy plays a crucial role in various diseases, and miRNAs can regulate cellular autophagy activity. Dysfunction of miRNAs is associated with the onset and drug resistance of lung cancer. Studying the interplay between miRNAs, autophagy, and drug resistance in lung cancer can lead to the development of new treatment interventions.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Mathematical & Computational Biology

Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments

Luke A. McGuinness et al.

Summary: Despite the availability of numerous software options for evidence synthesis, there is currently no universal tool for generating figures to display and explore risk-of-bias assessments. However, tools such as the R programming environment and Shiny have made it easy to create new tools for producing evidence syntheses. The new tool robvis facilitates the rapid production of publication-quality risk-of-bias assessment figures and is available as an R package and web app.

RESEARCH SYNTHESIS METHODS (2021)

Review Oncology

Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials

Jiatao Hao et al.

Summary: The study indicated that PARP inhibitors provide significant progression-free survival benefits for patients with ovarian cancer, regardless of BRCA mutation status. However, treatment with PARP inhibitors is associated with increased risks of specific treatment-related adverse events.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Review Oncology

Evaluation of efficacy and safety of PARP inhibitors in breast cancer: A systematic review and meta-analysis

Xiao-Fei Chang et al.

Summary: The study found that PARPi had better progression-free survival and overall response rate compared to chemotherapy in breast cancer patients, but also had a higher risk of grade 3-4 thrombocytopenia. PARPi was a better choice for patients who had not received previous platinum treatment.

BREAST (2021)

Article Oncology

Veliparib in Combination With Platinum-Based Chemotherapy for First-Line Treatment of Advanced Squamous Cell Lung Cancer: A Randomized, Multicenter Phase III Study

Suresh S. Ramalingam et al.

Summary: The study found no therapeutic benefit of adding veliparib to first-line chemotherapy in current smokers with advanced sqNSCLC. However, the LP52 signature may identify a subgroup of patients likely to derive benefit from veliparib with chemotherapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

A Dose-finding Study Followed by a Phase II Randomized, Placebo-controlled Trial of Chemoradiotherapy With or Without Veliparib in Stage III Non-small-cell Lung Cancer: SWOG 1206 (8811)

Athanassios Argiris et al.

Summary: The study evaluated the incorporation of the PARP inhibitor veliparib into chemoradiotherapy for stage III non-small-cell lung cancer. Despite the study ending early, the combination was found to be feasible and well tolerated, although efficacy could not be accurately determined. Promising prospects for further evaluation of PARP inhibitors in lung cancer are highlighted.

CLINICAL LUNG CANCER (2021)

Review Oncology

PARP Inhibitors in Small-Cell Lung Cancer: Rational Combinations to Improve Responses

Erik H. Knelson et al.

Summary: Small-cell lung cancer has a poor prognosis with limited treatment options. PARP inhibitors have shown promise as a therapeutic target, especially when used in combination therapies that contribute to DNA damage, inhibit the DNA damage response, or activate the immune system. Identifying biomarkers and developing treatment combinations based on the evolving classification of small-cell lung cancer subtypes and gene expression patterns will be crucial for improving outcomes in this challenging cancer.

CANCERS (2021)

Article Oncology

Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naive Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study

Lauren Averett Byers et al.

Summary: The study found that veliparib combined with platinum chemotherapy and maintenance therapy improved progression-free survival in first-line treatment of ED-SCLC, but did not show a corresponding benefit in overall survival. Patients may experience common hematologic toxicities during treatment. Further research is needed to determine the role of biomarkers in this setting.

CLINICAL CANCER RESEARCH (2021)

Review Oncology

Poly (ADP-ribose) polymerase inhibitors in solid tumours: Systematic review and meta-analysis

Francesco Schettini et al.

Summary: The study demonstrated the significant role of PARPis in the treatment of metastatic solid tumors, improving PFS, ORR, and OS regardless of the presence of BRCA1/2 mutations. Subgroup analysis revealed significant differences in outcomes based on tumor site, treatment line, control arm, and type of PARPi used.

EUROPEAN JOURNAL OF CANCER (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Oncology

Veliparib in combination with carboplatin/paclitaxel-based chemoradiotherapy in patients with stage III non-small cell lung cancer

David E. Kozono et al.

Summary: This study evaluated the effects of veliparib in combination with chemoradiotherapy on patients with unresectable stage III NSCLC, demonstrating acceptable safety profile and antitumor activity with a median progression-free survival of 19.6 months.

LUNG CANCER (2021)

Article Oncology

Veliparib and nivolumab in combination with platinum doublet chemotherapy in patients with metastatic or advanced non-small cell lung cancer: A phase 1 dose escalation study

Jeffrey M. Clarke et al.

Summary: The study demonstrated the tolerability and efficacy of the quadruple combination therapy of veliparib with nivolumab and platinum doublet chemotherapy in patients with advanced/metastatic NSCLC with promising antitumor activity. This four-drug therapy showed no evidence of drug-drug interaction and could be a potential treatment option for NSCLC patients.

LUNG CANCER (2021)

Article Oncology

Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer

Julia Judd et al.

Summary: The study characterized the genomic landscapes of KRAS-mutated non-small cell lung cancer in a large national cohort, revealing that different KRAS mutation subtypes have distinct co-occurring mutations and genomic landscapes.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Oncology

Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT): A Randomized Mulicentar Phase II Trial

Alice P. Chen et al.

Summary: This trial evaluated the utility of tumor DNA sequencing for treatment selection in patients with advanced cancer and somatic mutations in specific signaling pathways. Matching treatment regimens to aberrant pathways showed limited efficacy, underscoring the need for further investigation and development of more effective agents in precision cancer medicine.

JCO PRECISION ONCOLOGY (2021)

Review Oncology

PARP inhibitors as a new therapeutic option in metastatic prostate cancer: a systematic review

Raffaele Ratta et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2020)

Review Cell Biology

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

Maddison Rose et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Oncology

Evolving insights: how DNA repair pathways impact cancer evolution

Jiadong Zhou et al.

CANCER BIOLOGY & MEDICINE (2020)

Review Oncology

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers

Patrick G. Pilie et al.

CLINICAL CANCER RESEARCH (2019)

Article Medicine, General & Internal

RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

Article Oncology

Phase I study of veliparib in combination with gemcitabine

Ronald Stoller et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

Article Cell Biology

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Yves Pommier et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Oncology

DNA damage and the balance between survival and death in cancer biology

Wynand P. Roos et al.

NATURE REVIEWS CANCER (2016)

Review Biochemistry & Molecular Biology

Targeting the DNA Damage Response in Cancer

Mark J. O'Connor

MOLECULAR CELL (2015)

Article Respiratory System

Lung Cancer: Epidemiology, Etiology, and Prevention

Charles S. Dela Cruz et al.

CLINICS IN CHEST MEDICINE (2011)