Journal
MOLECULES
Volume 21, Issue 4, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules21040477
Keywords
2(1H)-pyridinethione; nucleosides; green synthesis; microwave; solvent-free conditions; antimicrobial
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A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-beta-D-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosides produced 2-(beta-D-arabinopyranosylthio)-3-cyanopyridines. The structures of the obtained products were confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR). The synthesized compounds were screened for the antimicrobial activity against a selection of Gram positive and Gram negative bacteria.
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