Journal
PLANT PHYSIOLOGY AND BIOCHEMISTRY
Volume 204, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.plaphy.2023.108123
Keywords
Graphene oxide; EPS-Coating; Allium cepa; Mitotic index; Chromosomal aberrations; Free radical generation; Membrane integrity
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This study investigated the toxicity of graphene oxide (GO) on Allium cepa root tip cells and found that GO caused various toxic effects, especially genotoxicity. The extracellular polymeric substances (EPS) potentially played a role in reducing the toxic effects by decreasing oxidative stress.
Graphene oxide (GO) is widely acknowledged for its exceptional biological and industrial applications. However, its discharge into the environment negatively impacts the ecosystem. This study aimed to investigate the toxicity of GO in Allium cepa root tip cells and the role of extracellular polymeric substances (EPS) in modulating its toxic effects. To evaluate toxicity, various endpoints like cell viability using Evans blue dye, cytotoxicity (mitotic index), genotoxicity (chromosomal aberrations), and oxidative stress assessments (total ROS, superoxide, hydroxyl radical production, and lipid peroxidation) were considered. The results suggest that pristine GO caused a dose-dependent increase in various toxicity parameters, especially the genotoxic effects. Oxidative stress generation by GO is proposed to be the principal mode of action. The EPS-corona formed on GO could potentially counteract the toxic effects, substantially reducing the oxidative stress within the cells.
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