4.8 Review

Recent advances in unraveling the mystery of combined nutrient stress in plants

Related references

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Article Plant Sciences

Aluminum Toxicity in Plants: Present and Future

Roghieh Hajiboland et al.

Summary: This paper reviews the current knowledge of plant responses to toxic aluminum ions (Al3+) in acidic soils. It discusses DNA damage response induced by Al3+, membrane transporters that avoid Al3+ toxicity, Al3+ exclusion mechanisms, the impact of Al3+ on plant nutrition, signaling pathways affected by Al3+ and their influence on gene expression, changes in plant growth regulators caused by Al3+ toxicity, and the beneficial effects of microorganisms on plants under Al3+ stress. Future research directions in these areas are also discussed.

JOURNAL OF PLANT GROWTH REGULATION (2023)

Article Biochemistry & Molecular Biology

The MEKK1-MKK1/2-MPK4 cascade phosphorylates and stabilizes STOP1 to confer aluminum resistance in Arabidopsis

Fanglin Zhou et al.

Summary: Aluminum (Al) toxicity severely limits crop production on acidic soils, which account for 40% of the world's potential arable land. The zinc finger transcription factor STOP1 plays a crucial role in mediating plant Al resistance. Our study reveals that the MEKK1-MKK1/2-MPK4 cascade positively regulates STOP1 phosphorylation and stability, thus conferring Al resistance in Arabidopsis. These findings provide insights into the upstream signaling pathway involved in Al-triggered STOP1 accumulation and highlight the importance of the MEKK1-MKK1/2-MPK4 cascade in Al signaling and resistance.

MOLECULAR PLANT (2023)

Article Biochemistry & Molecular Biology

ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis

Huikyong Cho et al.

Summary: Nutrient sensing and signaling play a crucial role in adapting growth to available resources. However, the molecular processes involved in sensing and responding to phosphorus (P) limitation to inhibit root growth are still unclear. In this study, the researchers identified a kinase called ARSK1 that attenuates early root growth inhibition under P limitation. They also discovered that ARSK1 phosphorylates and stabilizes RAPTOR1B, a component of TOR complex 1, to regulate root growth in response to P availability. These findings provide insights into the signaling components that regulate growth in relation to P availability.

CURRENT BIOLOGY (2023)

Article Plant Sciences

Differential modulation of Target of Rapamycin activity under single and combined iron and sulfur deficiency in tomato plants

Eleonora Coppa et al.

Summary: In the tomato, sulfur (S) and iron (Fe) have been demonstrated to have a close relationship in functionality and nutrition. However, little is known about the regulatory mechanisms underlying S/Fe interactions. Recent studies suggest that citrate may play a potential role in plant adaptation to Fe and S deficiency. TOR signaling, which is linked to organic acid metabolism, has been shown to be involved in S nutrient sensing in plants. The results of this study indicate that citrate may be involved in the signaling pathway of plant response to combined S/Fe deficiency through the TOR network.

PLANT JOURNAL (2023)

Article Plant Sciences

ELONGATED HYPOCOTYL 5 regulates BRUTUS and affects iron acquisition and homeostasis in Arabidopsis thaliana

Samriti Mankotia et al.

Summary: Iron is essential for plants and animals, and its limitation significantly affects crop yield and human nutrition. Plants have adapted strategies to regulate iron uptake and homeostasis, as well as modify root system architecture to survive under low iron conditions. Understanding the molecular mechanism of root growth responses has implications for plant breeding.

PLANT JOURNAL (2023)

Article Plant Sciences

The auxin signaling pathway contributes to phosphorus-mediated zinc homeostasis in maize

Zhonghua Wang et al.

Summary: Despite the recognition of P-Zn interaction in plants, the underlying mechanisms are still poorly understood. The study reveals that P supply decreases Zn concentration in maize shoots and roots. The auxin signaling pathway plays a crucial role in P-mediated Zn homeostasis through its effects on root system architecture. These findings highlight the importance of auxin-dependent RSA in maize for maintaining Zn homeostasis under P deficiency.

BMC PLANT BIOLOGY (2023)

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Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis

Jiangqin Wang et al.

Summary: ALMT1 is a protein in plants that mediates the transport of malate and plays a role in aluminum resistance in acidic soils. Its structure includes an anion channel with arginine residues for malate recognition. Aluminum binding induces structural changes that open the channel, allowing for malate transport.

CELL RESEARCH (2022)

Article Biochemistry & Molecular Biology

Direct inhibition of phosphate transport by immune signaling in Arabidopsis

Julian Dindas et al.

Summary: The availability of inorganic ortho-phosphate in soil is crucial for plant growth and fitness. This study reveals a link between plant immunity and phosphate homeostasis, showing that phosphate transport is repressed upon activation of immune responses. The repression is mediated by kinase-induced phosphorylation of the major phosphate transporter PHT1;4, and it negatively regulates anti-bacterial immunity in plant roots.

CURRENT BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Plant adaptation to low phosphorus availability: Core signaling, crosstalks, and applied implications

Javier Paz-Ares et al.

Summary: This article reviews the importance of phosphorus in plant growth and the adaptive mechanisms plants have developed to cope with phosphorus limitation. Research has identified several signaling molecules involved in the regulation of the phosphorus starvation rescue system, and complex interactions between phosphorus and other nutrients have been discovered. Improving phosphorus use efficiency can enhance plant uptake and utilization of phosphorus.

MOLECULAR PLANT (2022)

Article Plant Sciences

Calmodulin-like protein CML24 interacts with CAMTA2 and WRKY46 to regulate ALMT1-dependent Al resistance in Arabidopsis thaliana

Xue Zhu et al.

Summary: The study reveals the crucial role of CML24 in Arabidopsis aluminum resistance by regulating ALMT1-mediated malate exudation, interacting with CAMTA2 to enhance transcriptional activity, and suppressing the transcriptional repression of ALMT1 by WRKY46.

NEW PHYTOLOGIST (2022)

Review Plant Sciences

Mineral nutrient signaling controls photosynthesis: focus on iron deficiency-induced chlorosis

Rebecca Therby-Vale et al.

Summary: Understanding the complex relationship between nutrient homeostasis and photosynthesis has great potential for crop improvement.

TRENDS IN PLANT SCIENCE (2022)

Review Plant Sciences

HY5: A Pivotal Regulator of Light-Dependent Development in Higher Plants

Yuntao Xiao et al.

Summary: HY5 is a master regulator in plants that controls various important physiological and biological processes. It is conserved in function among different plant species. HY5 regulates the transcription of approximately one-third of genes at the whole genome level. The transcription, protein abundance, and activity of HY5 are tightly regulated by various factors.

FRONTIERS IN PLANT SCIENCE (2022)

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From mycorrhization to Pi homeostasis control: PHR is the key player!

Jinsheng Zhu et al.

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Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development

Christin Naumann et al.

Summary: Access to inorganic phosphate profoundly affects cellular activities and plant performance. This study reveals that Arabidopsis LPR1 acts as a phosphate-dependent cue to adjust root meristem maintenance by sensing subtle concentration differentials of external Fe availability via Fe redox signaling and cell wall modification.

CURRENT BIOLOGY (2022)

Article Biochemistry & Molecular Biology

A reciprocal inhibitory module for Pi and iron signaling

Meina Guo et al.

Summary: Phosphorous and iron are essential nutrients for plant growth and development. However, their availability to plants is often low. This study reveals a molecular link between phosphorous and iron master regulators, PHR2 and HRZs, which fine-tunes plant adaptation to phosphorous and iron availability in rice.

MOLECULAR PLANT (2022)

Article Plant Sciences

Uncoupling Aluminum Toxicity From Aluminum Signals in the STOP1 Pathway

Lea Le Poder et al.

Summary: Aluminum (Al) is a major limiting factor for crop production on acidic soils, inhibiting root growth and plant development. The SENSITIVE TO PROTON RHIZOTOXICITY1 (STOP1) transcription factor induces AL-ACTIVATED MALATE TRANSPORTER1 (ALMT1) to cope with Aluminum (Al) stress. Research has found that Al can trigger STOP1 signaling at concentrations as low as 2μM and can be detected at pH above 6.0.

FRONTIERS IN PLANT SCIENCE (2022)

Article Biochemistry & Molecular Biology

The ferroxidases LPR1 and LPR2 control iron translocation in the xylem of Arabidopsis plants

Zhong-Rui Xu et al.

Summary: This study reveals the crucial role of Arabidopsis ferroxidases LPR1 and LPR2 in controlling Fe translocation in the xylem. Knockout of LPR1 and LPR2 increases Fe deposition and disrupts Fe mobility in xylem vessels. The findings provide insights into the mechanism by which plants maintain Fe distribution and mobility in long-distance transport.

MOLECULAR PLANT (2022)

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Protecting plant nutrition from the effects of climate change

Zaigham Shahzad et al.

CURRENT BIOLOGY (2022)

Article Plant Sciences

The ferroxidases are critical for Fe(II) oxidation in xylem to ensure a healthy Fe allocation in Arabidopsis thaliana

Qing-Yang Zhu et al.

Summary: This study identified the crucial role of cell wall-resided ferroxidases LPRs in the vascular tissues of plants, facilitating the oxidation of Fe(II) to Fe(III) for long-distance transport and maintaining systemic Fe homeostasis for normal growth. Disruption of LPRs led to excessive Fe accumulation in xylem vessels, hindering Fe allocation and resulting in severe chlorosis in young leaves under Fe-deficient conditions.

FRONTIERS IN PLANT SCIENCE (2022)

Article Biochemistry & Molecular Biology

Plant growth stimulation by high CO2 depends on phosphorus homeostasis in chloroplasts

Nadia Bouain et al.

Summary: Elevated CO2 levels enhance plant growth by reducing phosphorus accumulation in chloroplasts, supporting the production of biomass. This adaptive mechanism is found in Arabidopsis thaliana and rice.

CURRENT BIOLOGY (2022)

Article Multidisciplinary Sciences

NIN-like protein 7 transcription factor is a plant nitrate sensor

Kun-Hsiang Liu et al.

Summary: Nitrate is a crucial nutrient and signaling molecule for plant growth. This study identified NLP7 as the primary nitrate sensor in plants, which regulates metabolic and growth responses upon nitrate perception. The use of a fluorescent split biosensor allowed visualization of single-cell nitrate dynamics in planta. Further analyses revealed that NLP7's nitrate sensor domain resembles that of a bacterial nitrate sensor, NreA.

SCIENCE (2022)

Article Biochemistry & Molecular Biology

Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus

Zhihua Zhang et al.

Summary: This study uncovered a fine-tuning mechanism of NIPR in the nucleus regulated by HINGE1, an MYB-transcription factor, which amplifies the phosphate response downstream of the cytoplasmic SPX4-PHR2 cascade and enables fine-tuning of N-P balance when nitrate supply is sufficient.

MOLECULAR PLANT (2021)

Article Multidisciplinary Sciences

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis

Martina K. Ried et al.

Summary: This study explores how the InsP(8)-SPX complex regulates plant Pi homeostasis by targeting the unique CC domain of PHRs. Structural analysis reveals that mutations in the CC domain affect the DNA binding capability of PHRs, resulting in constitutive Pi starvation responses.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

SIZ1 negatively regulates aluminum resistance by mediating the STOP1-ALMT1 pathway in Arabidopsis

Jiameng Xu et al.

Summary: This study identified the interaction between STOP1 and SUMO E3 ligase SIZ1, revealing how SIZ1 modulates STOP1 through SUMO modification to regulate ALMT1 expression and aluminum tolerance. Genetic evidence showed that STOP1/ALMT1 is epistatic to SIZ1 in regulating root growth response to Al stress. This study provides insights into the mechanism of SIZ1-STOP1-ALMT1 signaling module in root growth response to Al stress.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2021)

Article Plant Sciences

Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor

Caroline Mercier et al.

Summary: The E3 SUMO ligase SIZ1 modulates STOP1 signalling, with mutations increasing the expression of STOP1 target gene ALMT1 and enhancing root growth responses to aluminum and iron stress in a STOP1-dependent manner. Loss-of-function mutations in SIZ1 also lead to increased abundance of STOP1 in the root tip.

PLANT JOURNAL (2021)

Article Plant Sciences

Degradation of STOP1 mediated by the F-box proteins RAH1 and RAE1 balances aluminum resistance and plant growth in Arabidopsis thaliana

Qiu Fang et al.

Summary: The study reveals that in Arabidopsis, RAH1 promotes the degradation of STOP1 and its expression is controlled by STOP1. Loss of RAH1 in the rae1 mutant increases STOP1 protein levels, enhancing Al resistance, while plant growth in the rae1rah1 double mutant is affected, which can be rescued by introducing stop1 mutation.

PLANT JOURNAL (2021)

Article Multidisciplinary Sciences

Interdependent iron and phosphorus availability controls photosynthesis through retrograde signaling

Hye-In Nam et al.

Summary: Iron deficiency-induced chlorosis in plants depends on phosphorus availability and is regulated by a ROS-mediated retrograde signaling pathway involving the PHT4;4 chloroplast ascorbate transporter and the bZIP58 nuclear transcription factor. These genes prevent downregulation of photosynthesis genes under iron-phosphorus deficiency, leading to a stay-green phenotype. Chloroplastic ascorbate transport modulates ROS homeostasis to adapt photosynthesis to nutrient availability.

NATURE COMMUNICATIONS (2021)

Article Plant Sciences

GARP transcription factors repress Arabidopsis nitrogen starvation response via ROS-dependent and -independent pathways

Alaeddine Safi et al.

Summary: This study reveals that transcription factors of the HHO subfamily are key regulators of the nitrogen starvation response (NSR) in plants. They directly repress high-affinity nitrate transporters and control reactive oxygen species levels, defining a potential feed-forward signaling pathway for NSR.

JOURNAL OF EXPERIMENTAL BOTANY (2021)

Review Agronomy

Phosphorus Transformation in Soils Following Co-Application of Charcoal and Wood Ash

Prisca Divra Johan et al.

Summary: The fixation of phosphorus in acidic soils limits its availability for plant uptake, but using charcoal and wood ash together can help unlock this fixation. Soil amendments like compost and zeolite are effective in reducing phosphorus sorption sites and improving phosphorus uptake and crop productivity. Long-term application of charcoal and sago bark ash can positively impact soil properties, reducing phosphorus fixation and promoting nutrient release for maximum crop production.

AGRONOMY-BASEL (2021)

Review Environmental Sciences

Mechanisms underlying the phytotoxicity and genotoxicity of aluminum and their alleviation strategies: A review

Jipsi Chandra et al.

Summary: Aluminum (Al) can have both positive and negative effects on plant growth, depending on its concentration. Exclusion is an effective detoxification mechanism to alleviate Al toxicity, involving alterations in pH, exudation of chelating agents, cell wall immobilization, and Al efflux. Nanoparticles (NPs) show promise in mitigating metal stress and improving plant Al-tolerance on acidic soil.

CHEMOSPHERE (2021)

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The phyB-dependent induction of HY5 promotes iron uptake by systemically activating FER expression

Zhixin Guo et al.

Summary: The role of light signaling in plant iron uptake was explored in tomatoes, revealing that phytochrome B (phyB) plays a crucial role in light-induced iron uptake by activating the HY5 protein and the FER transcription factor. These findings demonstrate a systemic regulation of iron uptake by light quality in a phyB-HY5-FER-dependent manner, offering insights into the potential of manipulating light quality to enhance iron uptake and improve crop nutritional quality.

EMBO REPORTS (2021)

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Management of Phosphorus in Salinity-Stressed Agriculture for Sustainable Crop Production by Salt-Tolerant Phosphate-Solubilizing Bacteria-A Review

Gobinda Dey et al.

Summary: Soil salinity is a detrimental factor affecting plant growth and productivity, with phosphorus uptake being adversely affected by salinity stress. While adding additional P fertilizer is recommended to manage P deficit in saline soils, the low-efficiency of available P fertilizer use restricts P availability. Applying salinity-tolerant phosphate-solubilizing bacteria (ST-PSB) could be an effective and economical way to improve P availability in saline lands and mitigate the negative effects of salinity stress on plants.

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Live single-cell transcriptional dynamics via RNA labelling during the phosphate response in plants

Sahar Hani et al.

Summary: In this study, real-time visualization of transcriptional regulation in living Arabidopsis plants was achieved using the latest-generation RNA imaging system combined with microfluidics. The research revealed quantitative measurements of transcriptional activity at single loci in single cells, gene bursting, and large allelic differences, as well as the dominance of intrinsic noise in transcriptional control. Additionally, fast kinetics of transcriptional repression triggered by phosphate in roots and heterogeneity between neighboring cells were observed, providing valuable insights for future studies of signaling processes in plants.

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Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway

Pengliang Wei et al.

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Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation

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