Journal
PHYTOTHERAPY RESEARCH
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/ptr.7953
Keywords
apoptosis; autophagy; ginkgolide K; hypoxia-inducible factor 1; osteoarthritis; YAP
Categories
Ask authors/readers for more resources
This study aimed to determine and verify the therapeutic effect of Ginkgolide K (GK) on osteoarthritis (OA) and investigate its mechanism of action. In vivo and in vitro experiments showed that GK promoted the production of major components of the cartilage extracellular matrix and inhibited apoptosis of OA chondrocytes through the activation of hypoxia-inducible factor 1 alpha via the hypoxia signaling pathway. GK has a therapeutic effect on OA and has the potential to be developed into a new drug for OA treatment.
Osteoarthritis (OA) is a degenerative disease characterized by cartilage wear and degradation. Ginkgolide K (GK) is a natural compound extracted from Ginkgo biloba leaves and possesses anti-inflammatory and anti-apoptotic effects. We found that the biological characteristics of GK were highly consistent with those of OA medications. This study aimed to determine and verify the therapeutic effect of GK on OA and mechanism of its therapeutic effect. For the in vivo experiment, OA rats were regularly injected in the articular cavity with GK, and the curative effects were observed after 4 and 8 weeks. For the in vitro experiment, we treated OA chondrocytes with different concentrations of GK and then detected the related indices of OA. Through the in vivo and in vitro experiments, we found that GK could promote the production of major components of the cartilage extracellular matrix. Transcriptome sequencing revealed that GK may activate hypoxia-inducible factor 1 alpha via the hypoxia signaling pathway, which, in turn, activates yes-associated protein and inhibits apoptosis of OA chondrocytes. GK has a therapeutic effect on OA and, therefore, has the potential to be developed into a new drug for OA treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available