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Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

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Citri Reticulatae Pericarpium protects against isoproterenol-induced chronic heart failure via activation of PPARγ

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4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement

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Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway

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Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress

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Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency

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Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms

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Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

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The Global Burden of Cardiovascular Diseases and Risk Factors 2020 and Beyond

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Qi-Li-Qiang-Xin Alleviates Isoproterenol-Induced Myocardial Injury by Inhibiting Excessive Autophagy via Activating AKT/mTOR Pathway

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Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression

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Mitochondrial uncoupling, ROS generation and cardioprotection

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Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure

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Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

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Chinese patent medicine Xin-Ke-Shu inhibits Ca2+ overload and dysfunction of fatty acid β-oxidation in rats with myocardial infarction induced by LAD ligation

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PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

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Fatty Acid Oxidation in Cell Fate Determination

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Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases

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The Effect of Chinese Medicine on Lipid and Glucose Metabolism in Acute Myocardial Infarction Through PPARγ Pathway

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Pro-angiogenic Role of Danqi Pill Through Activating Fatty Acids Oxidation Pathway Against Coronary Artery Disease

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Kruppel-Like Factors Crippling and Uncrippling Metabolic Pathways

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Kruppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease

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Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder

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Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

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AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes

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Hypertriglyceridaemia and risk of coronary artery disease

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Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

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Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction

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PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part I: PPAR-α

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PPARα augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis

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Activation of PPAR-α in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure

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Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function

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Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart

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Cardioprotective effects of salidroside on myocardial ischemia-reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts

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Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

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Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy

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Danqi Pill regulates lipid metabolism disorder induced by myocardial ischemia through FATP-CPTI pathway

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Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondria! homeostasis

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Regulation of of Coronary Blood Flow in Health and Ischemic Heart Disease

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Tetramethylpyrazine (TMP) switches energy signalling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to resveratrol to ameliorate cardiac myocyte lipotoxicity

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KLF15 and PPAR alpha Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

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QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multicomponent and multi-target mode

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Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy

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Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death

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Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy

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AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease

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Kruppel-like Factor 4 Protein Regulates Isoproterenol-induced Cardiac Hypertrophy by Modulating Myocardin Expression and Activity

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Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism

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Mechanisms of heart failure in obesity

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SIRT1 and other sirtuins in metabolism

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PPARs Integrate the Mammalian Clock and Energy Metabolism

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SIRT1 and energy metabolism

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Cardiac Metabolism in Heart Failure Implications Beyond ATP Production

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Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats

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A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of the Effects of Qili Qiangxin Capsules in Patients With Chronic Heart Failure

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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

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Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress

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The Critical Role of Astragalus Polysaccharides for the Improvement of PPRAα-Mediated Lipotoxicity in Diabetic Cardiomyopathy

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PPARs at the crossroads of lipid signaling and inflammation

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Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

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Protective roles of SIRT1 in atherosclerosis

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Lipotoxicity in the heart

Adam R. Wende et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

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Mitochondrial SIRT3 and heart disease

Vinodkumar B. Pillai et al.

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SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

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Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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Myocardial Fatty Acid Metabolism in Health and Disease

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Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: New anti-angina mechanism implication

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Peroxisome proliferator-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis

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Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes

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Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids

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Metabolic manipulation in ischaemic heart disease, a novel approach to treatment

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Energy metabolism in heart failure

R Ventura-Clapier et al.

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Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy

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