Xiangshao Decoction alleviates gastric mucosal injury through NRF2 signaling pathway and reduces neuroinflammation in gastric ulcer rats

Article Plant Sciences

Hesperidin inhibits lung fibroblast senescence via IL-6/STAT3 signaling pathway to suppress pulmonary fibrosis

Di Han et al.

Summary: Hesperidin can inhibit lung fibroblast senescence and alleviate pulmonary fibrosis, indicating its potential as a treatment for idiopathic pulmonary fibrosis (IPF).

PHYTOMEDICINE (2023)

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Article Chemistry, Applied

Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury

Sitong Lu et al.

Summary: In this study, a gastric acid-responsive hydrogel of CS-NAC/ALG/TCP was developed and evaluated for its protective effects against alcohol-induced gastric mucosal injury in mice. The results showed that the hydrogel improved oxidative stress, reduced inflammation, and protected gastric mucosa, while also enhancing alcohol metabolism enzymes. This suggests that CS-NAC/ALG/TCP could be a promising treatment for alcohol-induced gastric injury.

CARBOHYDRATE POLYMERS (2022)

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Article Immunology

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

Sen Liu et al.

Summary: Lateral ventricle administration of BMSC-exos improved AD-like behaviors and inhibited glial activation and neuroinflammation in the hippocampus of mice. Additionally, it upregulated the expression of synapse-related proteins and BDNF.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Pharmacology & Pharmacy

Association Between Regular Use of Gastric Acid Suppressants and Subsequent Risk of Cholelithiasis: A Prospective Cohort Study of 0.47 Million Participants

Man Yang et al.

Summary: This study evaluated the association between regular use of proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) with the risk of cholelithiasis. The study found that regular use of PPIs or H2RAs was associated with an increased risk of cholelithiasis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Gastroenterology & Hepatology

Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design

Thi Ngoc Mai Nguyen et al.

Summary: This study found a significant association between low-dose aspirin and the incidence of gastric and duodenal ulcers in the new-user design. However, this association was not significant or weaker in the prevalent-user design. Therefore, it is important to consider the risks and benefits and monitor gastrointestinal symptoms when initiating low-dose aspirin treatment.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

The dual gastro- and neuroprotective effects of curcumin loaded chitosan nanoparticles against cold restraint stress in rats

Kholoud A. Ali et al.

Summary: Curcumin loaded chitosan nanoparticles show gastroprotective and neuroprotective effects against stress-induced gastric ulcer and neurobehavioral deficits. The study also explores the potential link between neuroinflammation and certain brain substances in stress-induced brain dysfunction.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Immunology

Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells

Surabhi Surabhi et al.

Summary: This study reveals the role of pneumococcal-derived H2O2 in initiating epithelial cell death by activating the NLRP3 inflammasome and mediating IL-1 beta production. The cell death is caused by both apoptotic and pyroptotic pathways, mediated by the activation of caspase-3/7 and caspase-1.

JOURNAL OF INNATE IMMUNITY (2022)

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Article Pharmacology & Pharmacy

Anti-Inflammatory Effect of Vanillin Protects the Stomach against Ulcer Formation

Murilo Piologo Ciciliato et al.

Summary: Vanillin has a gastroprotective effect by maintaining gastric mucus and modulating the local inflammatory response, which includes decreasing the levels of inflammatory cytokines and regulating the expression of related genes.

PHARMACEUTICS (2022)

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Article Medicine, Research & Experimental

AMPK/mTOR-driven autophagy & Nrf2/HO-1 cascade modulation by amentoflavone ameliorates indomethacin-induced gastric ulcer

Mohamed F. Balaha et al.

Summary: Amentoflavone can alleviate indomethacin-induced gastric ulcer by enhancing autophagy, modulating the AMPK/mTOR pathway, inhibiting oxidative stress, and suppressing apoptosis. Furthermore, it can also suppress gastric mucosal inflammation.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Plant Sciences

An insight into the anti-ulcerogenic potentials of medicinal herbs and their bioactive metabolites

Sowkat Jahan Shipa et al.

Summary: This review presents a comprehensive analysis of the ethnomedicinal and pharmacological prospects of various plant species in terms of their gastroprotective and antiulcer activities. The findings suggest the potential of developing plant-derived products for the treatment of peptic ulcer disease.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Cell Biology

A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers

Rui Xu et al.

Summary: This study identifies a semaphorin-plexin signaling pathway that regulates gastrin expression in gastric G cells, thus controlling food-stimulated gastrin release and gastric acid secretion. The RasGAP protein Rasal1 is identified as a central mediator of this pathway. Additionally, the study demonstrates the potential therapeutic application of recombinant semaphorin 4D in alleviating peptic ulcer disease in mice.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Microbiology

Proton Pump Inhibitor-Induced Gut Dysbiosis Increases Mortality Rates for Patients with Clostridioides difficile Infection

Cheng-Yu Lin et al.

Summary: This study found that daily use of proton pump inhibitors (PPIs) was the only avoidable risk factor for death in patients with CDI. With longer duration of PPI use, the mortality rate was higher in CDI patients. Decreased relative abundance of Prevotella copri and Ruminococcus gnavus, and increased relative abundance of Parabacteroides merdae and Clostridioides difficile, in line with daily PPI use duration, were significantly associated with the death of CDI patients.

MICROBIOLOGY SPECTRUM (2022)

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Article Chemistry, Applied

Effects of a polysaccharide extract from Amomum villosum Lour. on gastric mucosal injury and its potential underlying mechanism

Huifan Liu et al.

Summary: AVLP-2 is a novel acidic polysaccharide isolated from Amomum villosum Lour. It has antioxidant and anti-inflammatory effects by regulating ROS and inflammatory factors. Animal experiments demonstrate that AVLP-2 can improve the oxidative stress status of the gastric mucosa and reduce alcohol-induced inflammation.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Multidisciplinary

Oral supramolecular nanovectors for dual natural medicine codelivery to prevent gastric mucosal lesion

Yun Chen et al.

Summary: In this study, supramolecular nanovectors containing dual natural medicines were fabricated using biomaterials approved by the drug administration. These nanovectors exhibited superior intestinal absorption and bioavailability, and exerted protective effects on gastric mucosal lesions by decreasing oxidative stress and inflammatory level. Molecular docking results and computational simulations provided insights into the mechanisms of action.

NANOSCALE (2022)

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Letter Gastroenterology & Hepatology

Risk stratification for proton pump inhibitor-associated type 2 diabetes: a population-based cohort study

[Anonymous]

GUT (2021)

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Article Medical Laboratory Technology

Epidemiology changes in peptic ulcer diseases 18 years apart explored from the genetic aspects of Helicobacter pylori

TSUNG-HSING CHEN et al.

Summary: Independent decreases of H. pylori infection, gastric ulcer, and duodenal ulcer have been observed over the decades. In H. pylori positive patients, the prevalence of duodenal ulcers has decreased over time, while the prevalence of gastric ulcers remained unchanged. Gastric ulcer/cancer patients showed a higher prevalence of the MboI-defined genotype 3 UreC gene.

TRANSLATIONAL RESEARCH (2021)

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Article Oncology

The Association between Ranitidine Use and Gastrointestinal Cancers

Gerald McGwin

Summary: N-nitrosodimethylamine (NDMA) is a probable carcinogen found in ranitidine and has been linked to specific cancers through dietary and occupational exposure. However, studies specifically focusing on ranitidine exposure are limited. This study evaluates the association between ranitidine use and gastrointestinal cancer, suggesting an increased risk of certain cancers associated with NDMA-contaminated ranitidine.

CANCERS (2021)

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Review Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for peptic ulcer disease 2020

Tomoari Kamada et al.

Summary: The revised guidelines by the Japanese Society of Gastroenterology provide therapeutic algorithms for different types of peptic ulcers based on complications, offering specific drug treatment recommendations for various ulcer types, including H. pylori eradication therapy and ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs).

JOURNAL OF GASTROENTEROLOGY (2021)

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Article Multidisciplinary Sciences

Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

Enrico Gugliandolo et al.

Summary: Snail secretion filtrate has shown significant protective effects in reducing mucosal damages, oxidative stress, and inflammatory response in a murine model of ethanol-induced gastric ulcer. This suggests the potential usefulness of snail secretion filtrate in the treatment or prevention of gastric ulcer.

SCIENTIFIC REPORTS (2021)

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Review Cell & Tissue Engineering

Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer

Mahshid Saleh et al.

Summary: Peptic ulcer is a common gastrointestinal disorder that can be challenging to treat, often requiring long-term use of medication. Stem cell therapy, particularly using adipose-derived mesenchymal stem cells, is a promising new approach for patients who do not respond to conventional treatments or experience recurring ulcers.

STEM CELL RESEARCH & THERAPY (2021)

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Review Cell Biology

The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications

Andrzej S. Tarnawski et al.

Summary: This article reviews the cellular and molecular mechanisms of gastric ulcer healing, focusing on the processes involving cell dedifferentiation, proliferation, migration, re-epithelialization, angiogenesis, and more, all controlled by growth factors and cytokines. Local therapy with specific growth factors and proteins can accelerate and improve ulcer healing, with future directions including gene and protein therapies, stem cells, and tissue engineering.

CELLS (2021)

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Review Chemistry, Medicinal