Journal
PHYTOCHEMISTRY LETTERS
Volume 57, Issue -, Pages 56-61Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2023.07.012
Keywords
Purine-diterpenoid derivatives; Ent -kaurane diterpenoid; PCSK9 inhibition activity
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Three new ent-kauranoids with an adenine group and six known ent-kauranoids were isolated from Isodon japonica var. glaucocalyx. The structures of the compounds were determined using NMR and MS measurements, and the absolute configuration of one compound was determined using experimental and calculated electronic circular dichroism spectra. Compounds 6 and 8 exhibited significant inhibitory activities on PCSK9 expression at 20 μM.
Three new (glaucocalyxin L-N, 1-3) and six known ent-kauranoids (4-9) were isolated from the aerial part of Isodon japonica var. glaucocalyx. Compounds 1 and 2 are ent-kaurane-type diterpenoids with an adenine group. The structures of the isolated compounds were established using NMR and MS measurements and the absolute configuration of compound 3 was determined using experimental and calculated electronic circular dichroism spectra. Compounds 6 and 8 showed relatively remarkable inhibitory activities on proprotein convertase subtilisin/kexin 9 (PCSK9) expression at 20 & mu;M.
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