Ent-eudesmane sesquiterpenoids from the Chinese liverwort Chiloscyphus polyanthus

Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive spectroscopy analysis, electronic circular dichroism calculations, as well as biosynthetic considerations. The cytotoxicity against HepG2 (Human hepatocellular carcinomas) cancer cell line, and anti fungal activity against Candida albicans SC5314 of all isolated ent-eudesmane sesquiterpenoids were preliminarily tested, results showed that the tested compounds did not display obvious cytotoxicity and antifungal activities under the tested concentration.

Automated summary

Seven new ent-eudesmane sesquiterpenoids (1-7) and seven known analogs (8-14) were isolated from Chiloscyphus polyanthus var. rivularis, a liverwort plant from China. Their structures were determined using spectroscopy analysis, electronic circular dichroism calculations, and biosynthetic considerations. Preliminary tests showed that these isolated compounds did not exhibit significant cytotoxicity against HepG2 cancer cells and antifungal activity against Candida albicans SC5314.