Journal
MOLECULES
Volume 21, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/molecules21111510
Keywords
tropane alkaloids; granatane alkaloids; secondary metabolism; metabolic engineering
Funding
- Texas Tech University
- Center for Active Learning and Undergraduate Engagement at Texas Tech University
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The tropane and granatane alkaloids belong to the larger pyrroline and piperidine classes of plant alkaloids, respectively. Their core structures share common moieties and their scattered distribution among angiosperms suggest that their biosynthesis may share common ancestry in some orders, while they may be independently derived in others. Tropane and granatane alkaloid diversity arises from the myriad modifications occurring to their core ring structures. Throughout much of human history, humans have cultivated tropane- and granatane-producing plants for their medicinal properties. This manuscript will discuss the diversity of their biological and ecological roles as well as what is known about the structural genes and enzymes responsible for their biosynthesis. In addition, modern approaches to producing some pharmaceutically important tropanes via metabolic engineering endeavors are discussed.
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