Journal
PHYSIOLOGY & BEHAVIOR
Volume 268, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2023.114233
Keywords
Sign -tracking; Addiction; Serotonin; Fluoxetine; Escitalopram; Citalopram
Categories
Ask authors/readers for more resources
This study examined the effectiveness of serotonergic anti-depressants in reducing sign-tracking behavior and preventing cue-triggered relapse. The results showed that these drugs were able to reduce sign-tracking behavior, although their effects on goal-tracking varied.
Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian conditioned approach behavior directed at the conditioned stimulus. The study examined one strategy for reducing the magnetic pull of drug-associated conditioned stimuli, using selective serotonin reuptake inhibitors (SSRIs) citalopram (0, 10, and 20 mg/kg), escitalopram (0, 10, and 20 mg/kg) and fluoxetine (0, 5, and 10 mg/kg). Male Sprague-Dawley rats were first trained in a standard sign-tracking task and then acutely administered these drugs in a series of three experiments. In each study, it was found that measures of sign-tracking were reduced, although effects on goal -tracking were different between drugs. This study provides evidence that administration of serotonergic anti-depressants is effective in reducing sign-tracking and may have some efficacy in preventing cue-triggered relapse.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available