☆ 4.7 Review

Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases

PHARMACOLOGY & THERAPEUTICS (2023)

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Summary: This review presents recent discoveries regarding the role of the mechanosensitive ion channel Piezo1 in various diseases, particularly in tumor progression and cardiac mechanobiology. Based on recent findings, Piezo1 could be upregulated in cardiac fibroblasts due to mechanical stress and pro-inflammatory stimuli after myocardial injury, leading to fibrosis progression.

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Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry

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Summary: Mechanosensing is crucial for various physiological processes, and two major mechanosensing systems, focal adhesions and mechanosensitive ion channels, can convert mechanical features of the microenvironment into biochemical signals. Interestingly, it has been discovered that the mechanosensitive calcium-permeable channel Piezo1, previously thought to be diffusive on plasma membranes, binds to matrix adhesions in a force-dependent manner, thereby promoting cell spreading, adhesion dynamics, and calcium entry in normal cells but not in most cancer cells.

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Integrin Conformational Dynamics and Mechanotransduction

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Article Respiratory System

Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis

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Summary: This article describes a genome-wide meta-analysis study on the risk of idiopathic pulmonary fibrosis (IPF), identifying five robust novel genetic association signals related to IPF risk.

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Summary: Mechanobiology explores how mechanical forces and properties affect biological systems and how those systems control mechanical parameters. Disrupted mechanobiology has been found to play a significant role in various diseases. Understanding this complex process can help develop more effective treatment strategies and advance the fields of regenerative and personalized medicine.

TRENDS IN MOLECULAR MEDICINE (2022)

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Article Biology

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

Yan Zou et al.

Summary: This study demonstrates that TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy and dysfunction through the Ca2+/CaMKII mediated activation of NF kappa B-NLRP3. Therefore, TRPV4 may represent a potential therapeutic drug target for cardiac hypertrophy and dysfunction after pressure overload.

ELIFE (2022)

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New Insights into Hippo/YAP Signaling in Fibrotic Diseases

Masum M. Mia et al.

Summary: Fibrosis is a defective wound healing process often seen after chronic injury and/or inflammation in various organs. The Hippo signaling pathway plays a crucial role in the pathophysiology of fibrotic diseases, regulating cell proliferation, apoptosis, cell fate decisions, and contributing to the development of organ fibrosis.

CELLS (2022)

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Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

Ning Li et al.

Summary: This review discusses the correlation between biomechanical cues and liver diseases from the viewpoint of mechanobiology. At the cellular level, changes in mechanical microenvironment induce phenotypic and functional alterations of hepatic cells, promoting liver fibrogenesis and hepatocarcinogenesis. At the molecular level, mechanical forces are sensed and transmitted into hepatic cells, activating various mechanotransduction pathways and regulating cell function.

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Article Oncology

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Summary: The combination therapy of defactinib, pembrolizumab, and gemcitabine showed good tolerability and safety, promising preliminary efficacy, and biomarker activity in infiltrative T lymphocytes in PDAC patients.

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FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Pathology

Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis

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Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Rheumatology

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Summary: The study aimed to investigate the effects of abituzurnab in systemic sclerosis-associated interstitial lung disease (SSc-ILD), but was terminated prematurely due to slow enrollment, preventing a detailed analysis of efficacy.

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Article Biochemistry & Molecular Biology

Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors

Shaun Fell et al.

Summary: This study reveals a crucial role of TG2 in inducing the myofibroblast phenotype in idiopathic pulmonary fibrosis (IPF) and demonstrates the potential of TG2-selective inhibitors as therapeutic agents for fibrotic lung diseases like IPF.

AMINO ACIDS (2021)

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Review Multidisciplinary Sciences

The cellular mechanobiology of aging: from biology to mechanics

Apratim Bajpai et al.

Summary: Aging is a chronic and complex process that results in degenerative physical and biological changes in living organisms, affecting the mechanobiological features of cells. These mechanobiological changes can lead to dysfunctions and diseases in various organ systems. Understanding the mechanobiological effects of aging is important in developing strategies to halt and reverse the aging process.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

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Review Engineering, Biomedical

Collagen crosslinking: effect on structure, mechanics and fibrosis progression

Wenyu Kong et al.

Summary: Biophysical properties of the extracellular matrix play a crucial role in regulating the progression of chronic diseases. Crosslinking reactions can rapidly alter cellular responses, driving disease progression. Understanding crosslinking mechanisms is essential for revealing disease progression mechanisms and developing new therapeutic strategies.

BIOMEDICAL MATERIALS (2021)

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Review Cell & Tissue Engineering

Multipotent stromal cells One name, multiple : identities

Hesham Soliman et al.

Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.

CELL STEM CELL (2021)

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Review Biochemistry & Molecular Biology

TRPV4 integrates matrix mechanosensing with Ca2+ signaling to regulate extracellular matrix remodeling

Chenfan Ji et al.

Summary: In healthy tissues, mechanosensors trigger the generation of Ca2+ signals for maintaining cell structure, while in diseases, dysregulated matrix remodeling is associated with disruptions of Ca2+ homeostasis and TRPV4 function. This review highlights the reciprocal regulation between TRPV4 in cell adhesions and matrix mechanics through Ca2+ signaling.

FEBS JOURNAL (2021)

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Article Cell Biology

Cadherin-11 and cardiac fibrosis: A common target for a common pathology

Lance A. Riley et al.

Summary: Cardiac fibrosis is a major health concern in cardiovascular diseases, characterized by fibroblast activation into myofibroblasts and caused by persistent inflammation and mechanical environment changes. Inhibiting cadherin-11 dimerization shows promise in preventing fibrotic diseases, including cardiac fibrosis, offering potential for improved treatments for heart disease patients.

CELLULAR SIGNALLING (2021)

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Article Cell Biology

Cross your heart? Collagen cross-links in cardiac health and disease

Lily S. Neff et al.

Summary: ECM remodeling in response to cardiac insults involves distinct types of turnover and deposition, with collagen cross-linking playing a critical role in cardiac fibrosis development. Understanding the cellular mechanisms of collagen cross-linking may lead to new treatments for fibrotic cardiac diseases.

CELLULAR SIGNALLING (2021)

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Article Cell Biology

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

Jiahao He et al.

Summary: The study identified that Piezo1 channel is overexpressed in myofibroblasts of hypertrophic scar (HS) tissues and plays a regulatory role in fibroblasts, thus participating in HS formation. Piezo1 activity enhances various cellular biological behaviors in response to mechanical stretch in dermal fibroblasts, including proliferation, motility, and differentiation. Additionally, blocking Piezo1 with GsMTx4 peptide injection protected rats from stretch-induced HS formation, suggesting Piezo1 as a potential therapeutic target for HS.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction

Fan Jiang et al.

Summary: The Piezo1 channel serves as a key cardiac mechanotransducer for converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling to maintain normal heart function.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression

Ping Zhang et al.

Summary: The study highlights the crucial role of kindlin-2 in lung fibroblast activation, collagen matrix synthesis, and pulmonary fibrosis progression. Therapeutic interventions targeting the kindlin-2 signaling pathway show promise in controlling this deadly lung disease.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

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Article Chemistry, Medicinal

TRPV4 antagonists: a patent review (2015-2020)

Brian G. Lawhorn et al.

Summary: TRPV4 is a widely expressed ion channel that regulates cellular signaling and has potential therapeutic applications for various human diseases. Recent progress in the discovery of TRPV4 antagonists has shown efficacy in pre-clinical models, suggesting promise for potential clinical benefits in the future.

EXPERT OPINION ON THERAPEUTIC PATENTS (2021)

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Review Immunology

The inflammatory speech of fibroblasts

Ronen Schuster et al.

Summary: Activation of fibroblasts is crucial for tissue repair and fibrosis, with novel tools revealing their heterogeneous nature within a larger population of overlapping cell types. Activated fibroblasts exhibit various functions and their understanding is vital for targeted intervention in fibroproliferative and fibrocontractive disorders.

IMMUNOLOGICAL REVIEWS (2021)

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Review Cell Biology

TRPV4 Mechanotransduction in Fibrosis

Ravi K. Adapala et al.

Summary: The review discusses the mechanism of fibrosis and proposes TRPV4 as a potential therapeutic target for the condition, highlighting the need for specific drugs in the treatment of fibrosis.

CELLS (2021)

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Article Cell Biology

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway

Yuanyuan Fu et al.

Summary: It was found in the study that increased ECM stiffness aggravates the progression of renal fibrosis through the Piezo1-p38MAPK-YAP pathway, and targeting mechanosensitive Piezo1 might be a potential therapeutic strategy for delaying the progression of renal fibrosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Letter Oncology

An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies

Alison Findlay et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds

Li Wan et al.

Summary: The study shows that Cx43 plays a crucial role in patch repair of deep wounds by facilitating fibroblast migration and fascia matrix movement, affecting scar formation and wound healing.

MATRIX BIOLOGY (2021)

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Review Cell Biology

Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts

Leander Stewart et al.

Summary: Cardiac fibroblasts (CF) play a crucial role in maintaining myocardial function and integrity after injury, but can also contribute to future susceptibility to heart failure. Mechanosensitive ion channels have been identified as key regulators of various CF functions involved in fibrotic cardiac remodelling, including cell proliferation, myofibroblast differentiation, and paracrine signalling. Understanding the role of these ion channels in CF may lead to the development of therapies for reducing pathological cardiac remodelling.

CELLS (2021)

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Review Cell Biology

Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease

Suhasini Rajan et al.

Summary: Members of the TRP superfamily, particularly TRPV4, play crucial roles in respiratory system physiology and pathology, serving as potential therapeutic targets for diseases like asthma, lung fibrosis, edema, and infections.

CELLS (2021)

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Article Cell Biology

Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing

Ramona Emig et al.

Summary: The mechanical environment of cardiac cells is continuously changing and plays a role in the function of cells, with Piezo1 identified as a key molecular player in human atrial fibroblast mechano-sensing. Piezo1 contributes to cytoskeleton organization through integrin pathways, aiding in cellular adaptation to matrix stiffness changes and transmitting cell stiffening signals to other cells through a paracrine mechanism involving interleukin-6.

CELLS (2021)

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Review Cell Biology

Mechanosensitive Regulation of Fibrosis

Shuying Yang et al.

Summary: Cells in the human body respond to environmental cues, and tissue mechanics play a key role in disease development. During inflammation, tissue stiffness is upregulated, promoting immune cell response and fibrotic phenotype formation.

CELLS (2021)

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Review Pharmacology & Pharmacy

Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities

Izabela Tuleta et al.

Summary: Myocardial fibrosis in diabetic patients can lead to heart failure and arrhythmia due to factors such as hyperglycemia, lipotoxicity, and insulin resistance. While various biological processes have been implicated in diabetic fibrosis, specific therapeutic strategies targeting the fibrotic response remain limited.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Fibroblasts: Origins, definitions, and functions in health and disease

Maksim Plikus et al.

Summary: Fibroblasts are diverse mesenchymal cells that play a role in tissue homeostasis and disease, producing complex extracellular matrix and creating signaling niches. They are transcriptionally and functionally heterogeneous across and within organs, encoding positional information and maintaining distinct cellular progeny. Their unique properties make them poised for tissue repair but can also drive fibrotic disorders if activated aberrantly.

CELL (2021)

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Article Gastroenterology & Hepatology

Single-Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell-Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice

Wu Yang et al.

Summary: The study found that in liver fibrosis, HSCs undergo significant transcriptomic changes rather than PFs, and HSCs are the exclusive source of myofibroblasts in CCL4-treated livers, while PFs are the major source in early cholestatic liver fibrosis. Single-cell RNA sequencing and lineage-tracing analysis uncovered differential gene-expression features between HSCs and PFs, providing evidence that these differences should be considered in developing antifibrotic therapeutic strategies.

HEPATOLOGY (2021)

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Article Peripheral Vascular Disease

Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling

Yuhao Zhang et al.

Summary: Hemodynamic overload leads to pathological cardiac hypertrophy, which is a major risk factor for heart failure. Piezo1, a novel mechanosensitive ion channel, plays a crucial role in the development of cardiac hypertrophy and may be a potential therapeutic target for cardiac dysfunction.

HYPERTENSION (2021)

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Review Immunology

COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

Alison E. John et al.

Summary: The COVID-19 pandemic started in late 2019 in Wuhan City, China and has since spread worldwide. The disease, caused by the novel SARS-CoV-2 virus, primarily affects the respiratory system but can also impact other bodily systems. Patients may develop features of interstitial pulmonary fibrosis, raising questions about the long-term effects and progression of the disease.

IMMUNOLOGICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The Role of Calcium in Wound Healing

Thayaalini Subramaniam et al.

Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

MRTF: Basic Biology and Role in Kidney Disease

Maria Zena Miranda et al.

Summary: A lesser known downstream effect of Rho family GTPases is the regulation of gene expression through the organization of the cytoskeleton. The key transcription factor MRTF plays a central role in this process, affecting various cellular functions related to cytoskeleton remodeling, contractility, and other processes. Additionally, MRTF is involved in the pathobiology of kidney disease, particularly in fibrotic processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung

Alessandro Marchioni et al.

Summary: Lung fibrosis is caused by the regenerative deficits of alveolar epithelium and dysregulated repair mechanisms, leading to fibroblast and myofibroblast proliferation and excessive extracellular matrix deposition. The increased parenchymal stiffness significantly affects respiratory mechanics, making the lung more susceptible to damage and non-physiological stress during breathing. Fibrotic lungs may have an anisotropic response to mechanical stresses due to their heterogeneous nature, which can favor the progression of pulmonary fibrosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Urology & Nephrology

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Insa M. Schmidt et al.

Summary: Analysis of gene expression profiles and the development of Luminex-based assays were used to identify promising non-invasive biomarkers of kidney fibrosis. CDH11, SMOC2, and PEDF were found to be associated with the severity of interstitial fibrosis and tubular atrophy, as well as progression to end-stage kidney disease in independent cohorts of chronic kidney disease patients.

KIDNEY INTERNATIONAL (2021)

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Article Cell Biology

A story of fibers and stress: Matrix-embedded signals for fibroblast activation in the skin

Mugdha Sawant et al.

Summary: Our skin is constantly exposed to mechanical challenges, with fibroblasts and myofibroblasts playing crucial roles in maintaining and repairing normal skin. However, failure of myofibroblasts to stop their activities can lead to issues such as scarring and fibrosis.

WOUND REPAIR AND REGENERATION (2021)

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Article Cell Biology

Engineered microenvironment for the study of myofibroblast mechanobiology

Ying Xu et al.

Summary: Myofibroblasts are mechanosensitive cells whose behaviors are regulated by the surrounding microenvironment. Engineered cell culture models have been developed to examine the effect of microenvironmental factors on myofibroblast biology, providing superior experimental conditions compared to conventional models. These models contribute to a greater understanding of myofibroblast behavior in tissue repair and scar formation.

WOUND REPAIR AND REGENERATION (2021)

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Article Cell Biology

Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming

Wolfgang Merkt et al.

Summary: The article discusses the mechanisms that limit myofibroblast activities during physiological tissue repair, as well as the pathological mechanisms leading to fibrotic diseases. Additionally, emerging anti-fibrotic therapies targeting myofibroblast fate are summarized.

WOUND REPAIR AND REGENERATION (2021)

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Article Cell Biology

Novel factors that activate and deactivate cardiac fibroblasts: A new perspective for treatment of cardiac fibrosis

Rebeca de Oliveira Camargo et al.

Summary: Heart disease with cardiac fibrosis is a leading cause of death in developed countries, surpassing cancer. Recent literature focuses on activating and deactivating mechanisms of cardiac fibroblasts. Activated fibroblasts contribute to acute wound healing and chronic fibrosis, while deactivation is less studied but shows potential therapeutic implications.

WOUND REPAIR AND REGENERATION (2021)

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Article Multidisciplinary Sciences

Disrupting biological sensors of force promotes tissue regeneration in large organisms

Kellen Chen et al.

Summary: Tissue repair and healing are complex processes, with large animals and humans forming fibrotic scar tissue during healing. Disrupting mechanical signaling in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Cheng-Cheng Deng et al.

Summary: This study examined fibroblast heterogeneity in keloid, a representative of fibrotic skin diseases, using single-cell RNA-seq. The results revealed that keloid fibroblasts could be divided into 4 subpopulations, with an increased percentage of mesenchymal fibroblasts playing a crucial role in collagen overexpression. This increased mesenchymal fibroblast subpopulation was also found in another fibrotic skin disease, scleroderma, suggesting a broad mechanism for skin fibrosis.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after trauma

Eleni Costa et al.

Summary: This study found that traumatic amniotic membrane defects can lead to differential responses in amniotic membrane cell populations, including cell migration, collagen release, and cell polarization. During the healing process, myofibroblasts and AMCs play different roles, ultimately achieving the repair of amniotic membrane defects.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy

Eswari Dodagatta-Marri et al.

Summary: The study demonstrates that the antibody ADWA-11 targeting alpha v beta 8 shows growth suppression or complete regression in various cancer models, especially when combined with other immunomodulators or radiotherapy. Additionally, the highest expression of alpha v beta 8 integrin is found in CD4+CD25+ T cells in tumors, and specific deletion of beta 8 from T cells is as effective as ADWA-11 in suppressing tumor growth.

CELL REPORTS (2021)

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Review Cell Biology

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions

Osvaldo Contreras et al.

Summary: Fibro-adipogenic progenitors in muscle are enigmatic and transformative interstitial cells that shape the microenvironment to support adult muscle homeostasis and regeneration. They serve as lineage precursors of specialized cells, including activated fibroblasts, adipocytes, and osteogenic cells. Recent research combining single-cell technologies with lineage tracing has provided new insights into the origins, definitions, and fate of fibro-adipogenic progenitors in muscle development, homeostasis, regeneration, and repair.

SKELETAL MUSCLE (2021)

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Review Cell Biology

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction

Nina Noskovicova et al.

Summary: This article explores the impact of foreign body reaction (FBR) caused by body implants on implant performance and patient life, and discusses controlling myofibroblast activity to reduce fibrosis and accumulation of stiff scar tissue.

CELLS (2021)

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Article Cell Biology

Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts

Meike C. Ploeg et al.

Summary: In this study, Piezo1 was identified as a mediator of stretch-induced Nppb expression, as well as other remodeling genes, in cardiac fibroblasts.

CELLS (2021)

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Article Engineering, Biomedical

Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β

Nina Noskovicova et al.

Summary: The fibrotic encapsulation of implants can be reduced by softening the implant surfaces and inhibiting the activation of TGF-beta 1. Stiff implants lead to enhanced intracellular stress, increased recruitment of integrins, and activated TGF-beta 1 signaling. Antagonizing integrin binding can suppress TGF-beta signaling and fibrotic encapsulation of stiff implants.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Biochemistry & Molecular Biology

Mechanosensitivity in Pulmonary Circulation: Pathophysiological Relevance of Stretch-Activated Channels in Pulmonary Hypertension

Solene Barbeau et al.

Summary: Various cell types in pulmonary arteries are constantly exposed to mechanical stimulations under conditions of pulmonary hypertension, with calcium-permeable channels playing a key role in maintaining cellular function and calcium homeostasis. SAC are non-selective cation channels that serve as membrane mechano-transducers in responding to physical forces.

BIOMOLECULES (2021)

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Article Respiratory System

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

Martin L. Decaris et al.

Summary: In patients with idiopathic pulmonary fibrosis, inhibition of alpha(v)beta(6) and alpha(v)beta(1) integrins together showed an additive effect in reducing type I collagen gene expression. The dual integrin inhibitor PLN-74809 demonstrated antifibrotic efficacy by dose-dependently reducing pulmonary Smad3 phosphorylation and collagen deposition in vivo, more effectively than clinically relevant concentrations of nintedanib or pirfenidone.

RESPIRATORY RESEARCH (2021)

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Review Respiratory System

The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?

Timothy N. Perkins et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease without effective therapies, leading to lung transplantation as the only viable option for survival. The receptor for advanced glycation endproducts (RAGE) plays a significant role in IPF, but its function remains incompletely understood.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2021)

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Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Cadherin-11 Is a Regulator of Intestinal Fibrosis

Eleonora Franze et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Article Physiology

Analysis of fibroblast migration dynamics in idiopathic pulmonary fibrosis using image-based scaffolds of the lung extracellular matrix

Marisa Tisler et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling

Chinmayee D. Bhedi et al.

FASEB JOURNAL (2020)

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Review Medicine, Research & Experimental

Role of macrophage TRPV4 in inflammation

Bidisha Dutta et al.

LABORATORY INVESTIGATION (2020)

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Review Biochemical Research Methods

Identification and characterization of substrates crosslinked by transglutaminases in liver and kidney fibrosis

Hideki Tatsukawa et al.

ANALYTICAL BIOCHEMISTRY (2020)

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Article Cardiac & Cardiovascular Systems

TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation

Ravi K. Adapala et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Article Gastroenterology & Hepatology

Mechanisms of Fibrosis Development in NASH

Robert F. Schwabe et al.

GASTROENTEROLOGY (2020)

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Review Immunology

Transforming growth factor-beta in tissue fibrosis

Nikolaos G. Frangogiannis

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Review Rheumatology

Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

Boris Hinz et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Developments, applications, and prospects of cryo-electron microscopy

Xu Benjin et al.

PROTEIN SCIENCE (2020)

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Review Cell Biology

Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis

Wolfgang Merkt et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

TGF-β1-A truly transforming growth factor in fibrosis and immunity

Monika Lodyga et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies

Andrew J. Haak et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Daniela M. Santos et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Fibrosis and cancer: A strained relationship

Bram Piersma et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Article Physiology

Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

Anna Kuntze et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Multidisciplinary Sciences

Matrix-transmitted paratensile signaling enables myofibroblast-fibroblast cross talk in fibrosis expansion

Longwei Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Critical Care Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

Peter M. George et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Urology & Nephrology

Targeting the progression of chronic kidney disease

Marta Ruiz-Ortega et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Review Cell Biology

When Stiffness Matters: Mechanosensing in Heart Development and Disease

Roberto Gaetani et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury

Tomohiro Yokota et al.

CELL (2020)

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Article Multidisciplinary Sciences

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Taylor S. Adams et al.

SCIENCE ADVANCES (2020)

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Review Biotechnology & Applied Microbiology

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Anwesha Dey et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Review Pharmacology & Pharmacy

Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma

Daniel J. Tschumperlin et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Biochemistry & Molecular Biology

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Zhenjun Deng et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

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Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

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Article Cell Biology

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts

Elena Godbout et al.

CELLS (2020)

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Article Multidisciplinary Sciences

Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin

Dongsheng Jiang et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

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Review Immunology

The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis

Tylah Miles et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

Nikolaos G. Frangogiannis

MOLECULAR ASPECTS OF MEDICINE (2019)

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Review Cell Biology

Matrix molecules and skin biology

Alexander Nystroem et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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Review Oncology

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Boris Hinz et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Article Dermatology

How stiff is skin?

Helen K. Graham et al.

EXPERIMENTAL DERMATOLOGY (2019)

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Article Oncology

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients With Head and Neck Cancer: Results of the Biology-Driven Phase 2 Clinical Trial Pravacur

Celine Bourgier et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

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Review Rheumatology

Emerging targets of disease-modifying therapy for systemic sclerosis

Elizabeth R. Volkmann et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

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Article Pharmacology & Pharmacy

Attenuation of pulmonary fibrosis in type I collagen-targeted reporter mice with ALK-5 inhibitors

Hideki Terashima et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

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Article Critical Care Medicine

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

Camille Moore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Review Cell Biology

The Extracellular Matrix Modulates the Metastatic Journey

FuiBoon Kai et al.

DEVELOPMENTAL CELL (2019)

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Article Biology

Connexin-43-dependent ATP release mediates macrophage activation during sepsis

Michel Dosch et al.

ELIFE (2019)

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Article Oncology

Resveratrol decreases TNFα-induced ICAM-1 expression and release by Sirt-1-independent mechanism in intestinal myofibroblasts

Vladana Domazetovic et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Article Multidisciplinary Sciences

Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride

Mesias Pedroza et al.

PLOS ONE (2019)

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Article Multidisciplinary Sciences

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

Pardis Pakshir et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis

Hon-Ping Ma et al.

CANCERS (2019)

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Review Biochemistry & Molecular Biology

Lysyl oxidases: from enzyme activity to extracellular matrix cross-links

Sylvain D. Vallet et al.

EXTRACELLULAR MATRIX (2019)

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Review Rheumatology

Macrophages and cadherins in fibrosis and systemic sclerosis

Sarah To et al.

CURRENT OPINION IN RHEUMATOLOGY (2019)

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Editorial Material Biochemistry & Molecular Biology

Special Issue: The Actin-Myosin Interaction in Muscle: Background and Overview

John Squire

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion

Nicola M. Blythe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Lisa M. Grove et al.

SCIENCE SIGNALING (2019)

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Article Cell Biology

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Andrew J. Haak et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models

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Piezo1 in the Lung: At Last!

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Characterization of Tissue Transglutaminase as a Potential Biomarker for Tissue Response toward Biomaterials

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Integrin activation by talin, kindlin and mechanical forces

Zhiqi Sun et al.

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Thomas Hof et al.

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Cadherin-11-mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

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TRP channels in cardiac and intestinal fibrosis

Ryuji Inoue et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

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An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis

Barbara Ulmasov et al.

HEPATOLOGY COMMUNICATIONS (2019)

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Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction

Alison K. Schroer et al.

JCI INSIGHT (2019)

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LTBPs in biology and medicine: LTBP diseases

Daniel B. Rifkin et al.

MATRIX BIOLOGY (2018)

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The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

Rachel S. Knipe et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts

Mozibur Rahman et al.

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Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis

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A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

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CELL (2018)

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CURRENT OPINION IN CELL BIOLOGY (2018)

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Signaling Crosstalk of TGF-/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer

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Jade Montgomery et al.

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Daniel J. Tschumperlin et al.

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Matthias Mack

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Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

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NATURE COMMUNICATIONS (2018)

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FRONTIERS IN PHYSIOLOGY (2018)

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ADVANCES IN WOUND CARE (2018)

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

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CURRENT OPINION IN CELL BIOLOGY (2017)

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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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JOURNAL OF CELL BIOLOGY (2016)

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AMERICAN JOURNAL OF PATHOLOGY (2015)

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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Boris Hinz

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

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NATURE COMMUNICATIONS (2015)

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STEM CELL REPORTS (2015)

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GENES & DEVELOPMENT (2014)

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TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

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YAP and TAZ Regulate Skin Wound Healing

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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NATURE REVIEWS DRUG DISCOVERY (2014)

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Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-Induced Pulmonary Fibrosis in Mice

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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

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Annual Review of Pathology-Mechanisms of Disease (2013)

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Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

Jessica L. Bell et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

Yong Zhou et al.

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TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals

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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

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NATURE MEDICINE (2013)

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The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

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PLOS ONE (2013)

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Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation

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PULMONARY PHARMACOLOGY & THERAPEUTICS (2013)

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Direct contact of fibroblasts with neuronal processes promotes differentiation to myofibroblasts and induces contraction of collagen matrix in vitro

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WOUND REPAIR AND REGENERATION (2013)

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Preclinical Models of Wound Healing: Is Man the Model? Proceedings of the Wound Healing Society Symposium

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ADVANCES IN WOUND CARE (2013)

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Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

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ARTHRITIS AND RHEUMATISM (2012)

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Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

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EXPERIMENTAL CELL RESEARCH (2012)

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Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

Daniel J. Schneider et al.

FASEB JOURNAL (2012)

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Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

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GENES & DEVELOPMENT (2012)

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Transglutaminase-2 Interaction with Heparin IDENTIFICATION OF A HEPARIN BINDING SITE THAT REGULATES CELL ADHESION TO FIBRONECTIN-TRANSGLUTAMINASE-2 MATRIX

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Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

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Soft tissue mechanotransduction in wound healing and fibrosis

Victor W. Wong et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

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Transglutaminase 2 and Its Role in Pulmonary Fibrosis

Keith C. Olsen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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The Single-Molecule Mechanics of the Latent TGF-β1 Complex

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CURRENT BIOLOGY (2011)

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Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

Beverly J. Crider et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition

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KIDNEY INTERNATIONAL (2011)

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Role of YAP/TAZ in mechanotransduction

Sirio Dupont et al.

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Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

Huifang Xu et al.

MATRIX BIOLOGY (2011)

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Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

Eric M. Small et al.

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Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions

Takeshi Kobayashi et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

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Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases

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DRUG DISCOVERY TODAY (2010)

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Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment

Vivian Barry-Hamilton et al.

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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

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Pharmacological Inhibition of Integrin αvβ3 Aggravates Experimental Liver Fibrosis and Suppresses Hepatic Angiogenesis

Eleonora Patsenker et al.

HEPATOLOGY (2009)

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The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner

Justin F. Shaffer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA

Yun Huang et al.

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Substrate Rigidity Regulates Ca2+ Oscillation Via RhoA Pathway in Stem Cells

Tae-Jin Kim et al.

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Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Inhibition of integrin alpha v beta 6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis

Khalid Puthawala et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

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The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

Antje Moeller et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)

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Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

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JOURNAL OF CELL SCIENCE (2008)

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Myofibroblast communication is controlled by intercellular mechanical coupling

Lysianne Follonier et al.

JOURNAL OF CELL SCIENCE (2008)

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Article Cell Biology

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Pierre-Jean Wipff et al.

JOURNAL OF CELL BIOLOGY (2007)

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Article Gastroenterology & Hepatology

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

Penelope C. Georges et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

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Article Oncology

Pravastatin inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats

Valrie Haydont et al.

CLINICAL CANCER RESEARCH (2007)

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Article Oncology

CCG-1423:: a small-molecule inhibitor of RhoA transcriptional signaling

Chris R. Evelyn et al.

MOLECULAR CANCER THERAPEUTICS (2007)

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Review Dermatology

Keratinocyte-fibroblast interactions in wound healing

Sabine Werner et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Review Medicine, Research & Experimental

Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

Thomas A. Wynn

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Review Dermatology

Formation and function of the myofibroblast during tissue repair

Boris Hinz

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Respiratory System

Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis

Angela Trovato-Salinaro et al.

RESPIRATORY RESEARCH (2006)

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Article Biochemistry & Molecular Biology

Junctional Adhesion Molecules (JAMs) are differentially expressed in fibroblasts and co-localize with ZO-1 to adherens-like junctions

Andrew P. Morris et al.

CELL COMMUNICATION AND ADHESION (2006)

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Article Oncology

Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer

Takuma Aikawa et al.

MOLECULAR CANCER THERAPEUTICS (2006)

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Article Cell Biology

Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers

JM Goffin et al.

JOURNAL OF CELL BIOLOGY (2006)

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Article Medicine, General & Internal

Genetic modifiers of lung disease in cystic fibrosis

ML Drumm et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Biochemistry & Molecular Biology

Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

AM Zuurmond et al.

MATRIX BIOLOGY (2005)

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Article Cell Biology

Myofibroblast development is characterized by specific cell-cell adherens junctions

B Hinz et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

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Review Hematology

Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling

B Hinz et al.

THROMBOSIS AND HAEMOSTASIS (2003)

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Article Cell Biology

α-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts

B Hinz et al.

MOLECULAR BIOLOGY OF THE CELL (2003)

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Article Biochemistry & Molecular Biology

β1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway

B Tian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Review Cell Biology

Myofibroblasts and mechano-regulation of connective tissue remodelling

JJ Tomasek et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

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Article Cell Biology

Alpha-smooth muscle actin expression upregulates fibroblast contractile activity

B Hinz et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

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Article Biophysics

Cell movement is guided by the rigidity of the substrate

CM Lo et al.

BIOPHYSICAL JOURNAL (2000)

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Article Oncology

Regulation of LPA-promoted myofibroblast contraction: Role of Rho, myosin light chain kinase, and myosin light chain phosphatase

M Parizi et al.

EXPERIMENTAL CELL RESEARCH (2000)

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