☆ 4.7 Article

A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk

PHARMACOLOGICAL RESEARCH (2023)

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BRITISH JOURNAL OF CANCER (2022)

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Article Oncology

ACLP promotes activation of cancer-associated fibroblasts and tumor metastasis via ACLP-PPARγ-ACLP feedback loop in pancreatic cancer

Ya-Xiong Li et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a fibrotic tumor microenvironment (TME) that promotes tumor invasion and metastasis. This study reveals the role of a protein called ACLP in PDAC. ACLP is mainly expressed in cancer-associated fibroblasts (CAFs) and is highly expressed in PDAC tissues. High ACLP expression is associated with poor overall survival and liver metastases in PDAC patients. ACLP promotes CAF activation and fibrosis, leading to PDAC invasion and metastasis. Mechanistically, ACLP promotes the expressions of MMP1 and MMP3 in CAFs. A feedback loop involving ACLP-PPAR gamma-ACLP is identified in PDAC CAFs, which could be a potential therapeutic target for PDAC.

CANCER LETTERS (2022)

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Article Oncology

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA

Zengyu Feng et al.

Summary: A novel lncRNA, LINC00623, was identified as a potential biomarker and therapeutic target for PDAC. It can discriminate patients with PDAC from patients with benign pancreatic neoplasms and healthy individuals, and promote the tumorigenicity and migratory capacity of PDAC cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Oncology

Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1

Jiewei Lin et al.

Summary: This study reveals that circPDK1 plays a crucial role in pancreatic cancer by modulating the miR-628-3p/BPTF axis and degrading BIN1. CircPDK1 is highly expressed in pancreatic tumor tissues and serum exosomes and is associated with poor survival. Exosomal circPDK1 promotes pancreatic cancer cell proliferation, migration, and glycolysis. Moreover, circPDK1 enhances the interaction between UBE2O and BIN1, leading to the UBE2O-mediated degradation of BIN1.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Medicine, Research & Experimental

LINC00960 regulates cell proliferation and glycolysis in pancreatic cancer through the miR-326-3p/TUFT1/AKT-mTOR axis

Bin Zhou et al.

Summary: This study found that LINC00960 inhibits cell proliferation and glycolysis in pancreatic cancer by mediating the miR-326-3p/TUFT1/AKT-mTOR axis.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2022)

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Article Plant Sciences

Celastrol upregulated ATG7 triggers autophagy via targeting Nur77 in colorectal cancer

Wenxin Zhang et al.

Summary: The study demonstrated that Celastrol induced apoptosis and autophagy in colorectal cancer cells, with Nur77 playing a crucial role in its anti-cancer effects and influencing the expression of ATG7.

PHYTOMEDICINE (2022)

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Article Plant Sciences

Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy

Zhu Zhang et al.

Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.

PHYTOMEDICINE (2022)

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Article Cell Biology

FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis

Kun Cai et al.

Summary: FOXD1 overexpression in pancreatic cancer is associated with adverse prognostic index and enhances aerobic glycolysis, proliferation, invasion, and metastasis of cancer cells.

CELL DEATH & DISEASE (2022)

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Article Medicine, Research & Experimental

ASPP2 promotes cell apoptosis in cervical cancer through inhibiting autophagy

Feiyun Jiang et al.

Summary: This study found that ASPP2 suppresses cell proliferation and promotes apoptosis of cervical cancer cells by inhibiting autophagy. These findings are of significant importance for potential targets in cervical cancer therapy.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Oncology

Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells

Juan Yi et al.

Summary: This study demonstrates that combination therapy with parthenolide (PTL) and arsenic trioxide (ATO) synergistically inhibits the proliferation of hepatocellular carcinoma (HCC) cells by suppressing stemness and self-renewal ability and inducing apoptosis. The study also reveals that the USP7-HUWE1-p53 pathway is involved in PTL enhancing ATO-induced apoptosis of HCC cell lines, and that PTL and ATO induce autophagic activity by inhibiting the PI3K/Akt/mTOR pathway.

FRONTIERS IN ONCOLOGY (2022)

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Article Multidisciplinary Sciences

BNIP3 enhances pancreatic cancer cell migration and proliferation via modulating autophagy under hypoxia

Hongmei Li et al.

Summary: This study investigated the roles of BNIP3 and autophagy in pancreatic ductal adenocarcinoma (PDAC) under hypoxia. The upregulation of BNIP3 enhanced cell migration and proliferation, while inhibition of autophagy impaired hypoxia-induced cell migration and proliferation. Additionally, blocking ERK1/2 MAPK signaling down-regulated BNIP3 expression and inhibited autophagic activation. These findings provide a potential drug target for the therapy of PDAC.

HELIYON (2022)

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Article Biochemistry & Molecular Biology

RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis

Ha Zhu et al.

Summary: This study identifies ZCCHC4 as a potential therapeutic target and predictor of poor prognosis in multiple types of cancer. ZCCHC4 promotes chemoresistance and inhibits apoptosis in cancer cells through its interaction with AL133467.2. Furthermore, ZCCHC4 blocks the interaction between AL133467.2 and gamma H2AX, leading to increased chemoresistance. These findings provide mechanistic insights into the roles of RNA-binding proteins in cancer progression and treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Oncology

E2F2 enhances the chemoresistance of pancreatic cancer to gemcitabine by regulating the cell cycle and upregulating the expression of RRM2

Qianfan Liu et al.

Summary: E2F2 has been shown to play a pro-oncogenic role in pancreatic cancer by promoting cell cycle transition and enhancing proliferation. Additionally, E2F2 enhances the resistance of pancreatic cancer cells to gemcitabine chemotherapy possibly through upregulating RRM2 and DCK expression.

MEDICAL ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest

Jinyu Shi et al.

Summary: This study reveals that oxiconazole exhibits anti-tumor effect against colorectal cancer (CRC) by inducing autophagy arrest and subsequent apoptosis. Mechanistically, oxiconazole downregulates the antioxidant enzyme peroxiredoxin-2 (PRDX2) to initiate autophagy, leading to growth suppression of CRC cells. The combination of oxiconazole and oxaliplatin achieves an improved anti-tumor effect.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Oncology

Proscillaridin A induces mitochondrial damage and autophagy in pancreatic cancer and reduces the stability of SMAD4 in Panc-1 cells

Jia Hou et al.

Summary: The study demonstrates that Pro A has anti-proliferative, anti-migratory, and anti-invasive effects on PC cells, with Panc-1 cells showing the highest sensitivity. In vivo experiments also show that Pro A can effectively inhibit tumor progression, while promoting cell apoptosis and autophagy. Furthermore, the high sensitivity of Panc-1 cells to Pro A may be partially attributed to the loss of SMAD4 expression.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Review Cell Biology

Autophagy in the physiological endometrium and cancer

Laura Devis-Jauregui et al.

Summary: Autophagy is a crucial biological function that helps maintain tissue homeostasis and metabolic health. Recent research has highlighted the significance of autophagy in the human endometrium and discussed therapeutic approaches utilizing autophagy.

AUTOPHAGY (2021)

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Article Pharmacology & Pharmacy

Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells

Ling Zhou et al.

Summary: Recent studies have shown that CBR1 is highly expressed in pancreatic cancer tissues and plays a role in regulating ROS generation and gemcitabine sensitivity. Inhibition of CBR1 by chrysin increases cellular ROS levels, leading to ferroptotic death in PC cells and enhancing sensitivity to gemcitabine. These findings suggest CBR1 as a potential therapeutic target for PC treatment and elucidate a novel mechanism underlying the anti-tumor effects of chrysin.

BIOCHEMICAL PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

The role of autophagy in pancreatic cancer progression

Yuanyang Wang et al.

Summary: Patients with pancreatic cancer have a poor prognosis due to difficulties in early diagnosis, high metastasis rates, and chemoresistance. Autophagy plays a dual role in cancer development, inhibiting cancer initiation while promoting cancer progression. Inhibiting autophagy can enhance drug efficacy but may also lead to drug resistance in pancreatic cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy

Zuzana Ezrova et al.

Summary: The resistance to mitochondrial inhibitors in pancreatic cancer is found to be mediated by increased mitophagic flux driven by MAPK/ERK signaling and linked to epithelial-to-mesenchymal transition. Mitochondria-targeted inhibitors, such as mitochondria-targeted tamoxifen, are effective in overcoming drug resistance mediated by SMAD4 deficiency or TGF beta signaling. These findings suggest potential strategies for developing targeted therapies for pancreatic cancer patients with SMAD4 as a predictive marker.

ONCOGENE (2021)

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Article Gastroenterology & Hepatology

PVT1 Knockdown Inhibits Autophagy and Improves Gemcitabine Sensitivity by Regulating the MiR-143/HIF-1α/VMP1 Axis in Pancreatic Cancer

Yun-Fei Liu et al.

Summary: The study showed that PVT1 knockdown can inhibit autophagy and improve gemcitabine sensitivity in pancreatic cancer by regulating the miR-143/HIF-1 alpha/VMP1 axis. This finding may help improve the therapeutic effects of chemotherapy drugs on pancreatic cancer.

PANCREAS (2021)

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Review Cell Biology

Extracellular vesicles in pancreatic cancer progression and therapies

Chao-Hui Chang et al.

Summary: Pancreatic cancer is a leading cause of cancer-related deaths worldwide due to delayed diagnosis and limited treatments. Pancreatic ductal adenocarcinoma accounts for more than 90% of all pancreatic cancers, with extracellular vesicles playing a crucial role in regulating tumor growth and metastasis. Understanding the factors in EVs derived from pancreatic ductal adenocarcinoma can provide insights into potential early diagnosis and therapeutic strategies against this deadly cancer.

CELL DEATH & DISEASE (2021)

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Review Cell Biology

The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells

Yibo Fu et al.

Summary: Mitochondria play important roles in the chemoresistance of pancreatic cancer by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Targeting certain factors in mitochondria may improve the sensitivity of pancreatic cancer cells to chemotherapeutic agents.

CELLS (2021)

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Review Chemistry, Applied

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Milad Ashrafizadeh et al.

Summary: Gene therapy using siRNA faces challenges, but chitosan nanoparticles as carriers show promise in overcoming siRNA issues and demonstrating potential in cancer therapy.

CARBOHYDRATE POLYMERS (2021)

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Article Environmental Sciences

Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells

Ya-Hui Chen et al.

Summary: The combination treatment of metformin and pitavastatin significantly reduces cell viability, induces cell cycle arrest, and exerts anticancer effects through various pathways, demonstrating a synergistic interaction in pancreatic cancer cells.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Oncology

Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy

Xiaoru Hu et al.

Summary: Cisplatin is a commonly used chemotherapy drug, but its efficacy is limited by nephrotoxicity. Autophagy plays a protective role in preventing kidney injury during cisplatin exposure, but may also hinder chemotherapy efficacy by protecting cancer cells. Targeting autophagy presents both therapeutic advances and challenges in improving cisplatin chemotherapy outcomes.

CANCERS (2021)

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Article Cell Biology

lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy

Lei Wang et al.

Aging-US (2021)

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Article Oncology

Panax Notoginseng Saponins Promote Cell Death and Chemosensitivity in Pancreatic Cancer through the Apoptosis and Autophagy Pathways

Li-Chao Yao et al.

Summary: Panax Notoginseng Saponins (PNS) exhibited inhibitory effects on the proliferation, migration, invasion, and autophagy of pancreatic cancer Miapaca2 and PANC-1 cells, while inducing apoptosis and increasing chemosensitivity to Gem.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Oncology

Long non-coding RNAs in the doxorubicin resistance of cancer cells

Saeed Ashrafizaveh et al.

Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.

CANCER LETTERS (2021)

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Article Oncology

Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer

Motofumi Suzuki et al.

Summary: This study found a functional interaction between radiation-induced autophagy and G2 checkpoint activation in highly radioresistant PDAC cells, each independently contributing to the radioresistance of these cells. These findings have important implications for the development of future radiation therapy strategies for PDAC.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Review Medicine, Research & Experimental

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

Sepideh Mirzaei et al.

Summary: GBM is a serious brain tumor with no cure, requiring new genetic approaches for treatment. The use of siRNA can target and silence genes responsible for disease progression in GBM cells.

LIFE SCIENCES (2021)

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Review Medicine, Research & Experimental

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

Sepideh Mirzaei et al.

Summary: siRNA can enhance sensitivity of cancer cells to chemotherapy by down-regulating specific genes, inhibiting cancer stem cell properties and related molecular pathways, as well as promoting cell cycle arrest and increased accumulation of chemotherapy drugs in cancer cells. Carriers such as nanoparticles and biological carriers are important in overcoming siRNA challenges and enhancing its effectiveness in reversing chemotherapy resistance.

LIFE SCIENCES (2021)

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Article Oncology

Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling

Xin Zhao et al.

Summary: Oridonin inhibits the proliferation of pancreatic carcinoma cells and induces apoptosis, while mediating its effects on cell proliferation, apoptosis, and autophagy through simultaneous inhibition of the phosphoinositide 3-kinase pathway and activation of the c-Jun N-terminal kinase pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

Mehrdad Zarei et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, and gemcitabine treatment may lead to overexpression of NURR1, a negative prognostic factor for patient survival. NURR1, induced by gemcitabine, regulates cancer cell growth and survival by modulating autophagy genes such as ATG7 and ATG12, contributing to drug resistance and cytoprotective autophagy. Targeting the NURR1-ATG7/ATG12 axis with a NURR1 antagonist like C-DIM12 could potentially enhance the efficacy of combination therapies with gemcitabine against PDAC.

CANCER RESEARCH COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

Co-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis

Xiaoxiao Chen et al.

Summary: A pH-responsive drug delivery system was formulated to enhance penetration of tumor and inhibit autophagy in pancreatic cancer. Through downregulating MMP-2 and paxillin, as well as reducing fibrosis, the system showed potential in inhibiting proliferation and metastasis of pancreatic cancer.

THERANOSTICS (2021)

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Article Cell Biology

TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status

Chen Liang et al.

AUTOPHAGY (2020)

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Article Cell Biology

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

Enyong Dai et al.

AUTOPHAGY (2020)

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Article Biochemical Research Methods

Upregulation of CD73 Confers Acquired Radioresistance and is Required for Maintaining Irradiation-selected Pancreatic Cancer Cells in a Mesenchymal State

Anna M. Nguyen et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

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Review Biochemistry & Molecular Biology

Autophagy and autophagy-related proteins in cancer

Xiaohua Li et al.

MOLECULAR CANCER (2020)

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Article Gastroenterology & Hepatology

Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells

Xiaolu Wei et al.

PANCREAS (2020)

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Editorial Material Cell Biology

Selective autophagy of MHC-I promotes immune evasion of pancreatic cancer

Keisuke Yamamoto et al.

AUTOPHAGY (2020)

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Article Oncology

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

Herbert J. Zeh et al.

CLINICAL CANCER RESEARCH (2020)

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Article Multidisciplinary Sciences

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

Sonia Alcala et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Mammalian STE20-like kinase 1 regulates pancreatic cancer cell survival and migration through Mfn2-mediated mitophagy

Yongli Hu et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Multidisciplinary Sciences

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto et al.

NATURE (2020)

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Article Chemistry, Medicinal

Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine-resistant human pancreatic cancer cells

Ji-Hua Lin et al.

PHYTOTHERAPY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Cefan Zhou et al.

MOLECULAR CANCER (2020)

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Article Oncology

Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer

Xuguang Yang et al.

CANCER IMMUNOLOGY RESEARCH (2020)

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Article Oncology

Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

Alexandra Thomas et al.

CANCERS (2020)

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Article Biochemistry & Molecular Biology

A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy

Youcheng Bian et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Biochemistry & Molecular Biology

SNHG14 enhances gemcitabine resistance by sponging miR-101 to stimulate cell autophagy in pancreatic cancer

Xiufeng Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Cell Biology

Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death

Ze Yu et al.

CELL PROLIFERATION (2019)

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Article Biochemistry & Molecular Biology

MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5

Zhi-Chao Wang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Toxicology

Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin

Hua Chen et al.

TOXICOLOGY IN VITRO (2019)

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Article Cell Biology

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

Shengnan Jia et al.

CELL DEATH & DISEASE (2019)

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Article Plant Sciences

Total flavonoid aglycones extract in Radix Scutellariae induces cross-regulation between autophagy and apoptosis in pancreatic cancer cells

Jiazhe Liu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Cell Biology

Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p

Chang Liu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

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Article Oncology

High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer

Cancan Zhou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Oncology

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

Hongze Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Pathology

Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling

Xiaokai Zhang et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Article Oncology

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton et al.

CANCER DISCOVERY (2019)

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Article Engineering, Biomedical

Synergistic cytotoxicity and co-autophagy inhibition in pancreatic tumor cells and cancer-associated fibroblasts by dual functional peptide-modified liposomes

Xiaoxiao Chen et al.

ACTA BIOMATERIALIA (2019)

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Review Biochemistry & Molecular Biology

The Role of Exosomes in Pancreatic Cancer

Bin Lan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Oncology

TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells

Ruizhi He et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Plant Sciences

Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1

Dai Haisu et al.

PHYTOMEDICINE (2019)

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Article Pharmacology & Pharmacy

PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells

Chunle Zhao et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Oncology

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Hongcheng Wang et al.

CANCER CELL INTERNATIONAL (2019)

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Article Gastroenterology & Hepatology

Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice

Kivanc Goerguelue et al.

GASTROENTEROLOGY (2019)

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Review Oncology

Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors

Prashanth Rawla et al.

WORLD JOURNAL OF ONCOLOGY (2019)

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Article Nanoscience & Nanotechnology

Targeted Codelivery of Docetaxel and Atg7 siRNA for Autophagy Inhibition and Pancreatic Cancer Treatment

Miaozun Zhang et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Biochemistry & Molecular Biology

Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells

Jinhui Zhu et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2018)

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Review Oncology

Targeting Autophagy in Cancer

Angelique V. Onorati et al.

CANCER (2018)

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Article Cell Biology

MicroRNA-29c Increases the Chemosensitivity of Pancreatic Cancer Cells by Inhibiting USP22 Mediated Autophagy

Limin Huang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Oncology

SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy

Feng Wang et al.

CLINICAL CANCER RESEARCH (2018)

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Article Medicine, Research & Experimental

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Prakash C. Thakur et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Review Cell Biology

Building and decoding ubiquitin chains for mitophagy

J. Wade Harper et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Article Chemistry, Medicinal

Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells

Ye Tian et al.

PHYTOTHERAPY RESEARCH (2018)

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Article Multidisciplinary Sciences

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

Arnaud Pommier et al.

SCIENCE (2018)

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Article Cell Biology

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

Scott J. Rodig et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Public, Environmental & Occupational Health

Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries

Hongmei Zeng et al.

LANCET GLOBAL HEALTH (2018)

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Article Oncology

USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy

Tao Ma et al.

CANCER LETTERS (2018)

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Article Biochemistry & Molecular Biology

Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells

Xu Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

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Article Pharmacology & Pharmacy

Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB

Ruizhi He et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

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Article Medicine, General & Internal

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

T. Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Cell Biology

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation

Qingcai Meng et al.

CELL DEATH & DISEASE (2018)

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Article Oncology

Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer

Chunli Wu et al.

CANCER MANAGEMENT AND RESEARCH (2018)

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Article Oncology

miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1

She Tian et al.

ONCOTARGET (2017)

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Article Gastroenterology & Hepatology

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

Sho Endo et al.

GASTROENTEROLOGY (2017)

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Article Medicine, Research & Experimental

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

Chuang Yang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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Article Gastroenterology & Hepatology

Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells

Sho Endo et al.

PANCREATOLOGY (2017)

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Article Oncology

Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer

Alok Ranjan et al.

TUMOR BIOLOGY (2017)

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Article Cell Biology

RGD-modified oncolytic adenovirus-harboring shPKM2 exhibits a potent cytotoxic effect in pancreatic cancer via autophagy inhibition and apoptosis promotion

Yanni Xu et al.

CELL DEATH & DISEASE (2017)

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Article Oncology

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

Maria Saveria Gilardini Montani et al.

CELLULAR ONCOLOGY (2017)

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Article Oncology

MicroRNA-410-3p attenuates gemcitabine resistance in pancreatic ductal adenocarcinoma by inhibiting HMGB1-mediated autophagy

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Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

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microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression

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More deaths from pancreatic cancer than breast cancer in the EU by 2017

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Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells

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ONCOLOGY LETTERS (2016)

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Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential

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Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

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Whole genomes redefine the mutational landscape of pancreatic cancer

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MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy

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GDC-0980-induced apoptosis is enhanced by autophagy inhibition in human pancreatic cancer cells

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Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs

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Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

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Ubiquitin-specific protease 22-induced autophagy is correlated with poor prognosis of pancreatic cancer

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Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway

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NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Autophagy in the pathogenesis of disease

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Autophagy: from phenomenology to molecular understanding in less than a decade

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Autophagosome formation: Core machinery and adaptations

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Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer - A Randomized controlled trial

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