4.7 Article

AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target

Related references

Note: Only part of the references are listed.
Article Oncology

Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050

Simiao Chen et al.

Summary: Cancers are a leading cause of mortality, accounting for nearly 10 million annual deaths worldwide, or 1 in 6 deaths. Cancers also negatively affect countries' economic growth. However, the global economic cost of cancers and its worldwide distribution have yet to be studied.

JAMA ONCOLOGY (2023)

Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

Article Gastroenterology & Hepatology

Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

Carolina F. Ruivo et al.

Summary: This study reveals that pancreatic ductal adenocarcinoma (PDAC) tumors establish a communication network mediated by cancer stem cells (CSC) and the protein agrin, which promotes tumor growth and therapy resistance. CSC release extracellular vesicles (EVs) that activate specific proteins, leading to increased tumor cell proliferation and transcriptional regulator activation. Targeting this communication network may provide a potential strategy for targeted therapy and has significant implications for cancer stem cells.
Article Anatomy & Morphology

Mechanism of IDH1-R132H mutation in T cell acute lymphoblastic leukemia mouse model via the Notch1 pathway

Yonghua Liu et al.

Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a clonal malignant disease with the involvement of Isocitrate Dehydrogenase 1-R123 (IDH1-R132 H) in its progression. IDH1-R132H mutation promotes T-ALL deterioration by enhancing cell proliferation and invasion, and inhibiting apoptosis. The mutation activates the Notch1 pathway to upregulate HES1 expression, downregulate PTEN expression, and trigger PI3K/AKT pathway, ultimately promoting malignant behaviors in T-ALL cells.

TISSUE & CELL (2022)

Article Oncology

Signatures of malignant cells and novel therapeutic targets revealed by single-cell sequencing in lung adenocarcinoma

Jiaqi Liang et al.

Summary: This study used single-cell transcriptomic data to analyze the malignant-cell-specific genes in lung adenocarcinoma. Seventy genes involved in tumor biology were identified, and a predictive model with an accuracy of 96.1% was constructed. Further experiments confirmed the upregulation of IRX2, SPINK13, and CAPN8 in lung adenocarcinoma, suggesting their potential as therapeutic targets.

CANCER MEDICINE (2022)

Article Medicine, Research & Experimental

miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways

Guoshu Bi et al.

Summary: The study identified miR-6077 as a key driver of cisplatin/pemetrexed resistance in lung adenocarcinoma (LUAD). Overexpression of miR-6077 desensitized LUAD cells to cisplatin/pemetrexed by affecting cell cycle and ferroptosis, leading to cell death. This research provides a novel therapeutic strategy for overcoming chemoresistance in clinical practice.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

Article Oncology

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma

Huan Zhang et al.

Summary: ARNTL2 is highly expressed in lung adenocarcinoma and serves as an independent predictor of poor prognosis in patients with lung adenocarcinoma. Knockdown of ARNTL2 promotes ferroptosis and inhibits EMT, cell proliferation, migration, and invasion in lung adenocarcinoma.

TRANSLATIONAL ONCOLOGY (2022)

Article Gastroenterology & Hepatology

Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation

Saiko Marui et al.

Summary: The roles of HES1 in the adult pancreas and pancreatic cancer are context-dependent. HES1 is not required for maintaining the adult pancreas under normal conditions, but is important for regeneration during recovery from pancreatitis. Furthermore, HES1 promotes early lesion formation while inhibiting the progression of late lesions in pancreatic cancer.

GASTROENTEROLOGY (2022)

Article Biochemistry & Molecular Biology

Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent Manner

Katarina Gros et al.

Summary: Neuronal agrin has an age-dependent role in promoting the proliferation of human myoblasts by binding to Lrp4 and activating MuSK.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer

Yiwei Huang et al.

Summary: The study reveals that TGF-beta plays a dual role in regulating glycolysis and cell proliferation in non-small cell lung cancer. HIF-1 alpha is identified as a critical factor in this process, potentially serving as a biomarker or therapeutic target for TGF-beta mediated cancer progression. The research findings provide insight into the metabolic reprogramming mechanisms in tumor cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Oncology

Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma

Zhencong Chen et al.

Summary: This study explores the cellular diversity and molecular complexity of the TME and ITH in different stages of LUAD using single-cell transcriptome analysis. Results reveal that advanced LUAD cells have a more complex TME and higher ITH level compared to early malignant cells, with significant diversity in cell-cell communication between different lesions of LUAD at the single-cell level.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Oncology

Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma

Huan Zhang et al.

Summary: Patients with ALK rearranged lung adenocarcinoma who have undergone radical surgery have distinct clinical features, with better prognosis and a higher likelihood of benefiting from targeted therapy, especially for stage II-III patients.

THORACIC CANCER (2021)

Article Oncology

Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo

Guoshu Bi et al.

Summary: Our study demonstrated that increased expression of GTF2E2 in LUAD tissue was negatively associated with patients' overall survival. Knocking down GTF2E2 inhibited LUAD cell proliferation, migration, invasion, promoted apoptosis in vitro, and attenuated tumor growth in vivo. Through LC-MS/MS analysis, we found that RPS4X may interact with GTF2E2 and mediate its regulatory effect on LUAD development through the mTOR pathway.

CANCER CELL INTERNATIONAL (2021)

Article Medicine, Research & Experimental

GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma

Wei Wang et al.

Summary: The study revealed that GALNT2 is highly expressed in LUAD and is associated with poor prognosis. GALNT2 promotes cancer cell proliferation and migration by activating the Notch/Hes1-PTEN-PI3K/Akt signaling axis, suggesting a potential new therapeutic target for LUAD.

LIFE SCIENCES (2021)

Article Environmental Sciences

Gamma-Secretase Inhibitor (DAPT), a potential therapeutic target drug, caused neurotoxicity in planarian regeneration by inhibiting Notch signaling pathway

Zimei Dong et al.

Summary: The study found that the inhibition of the Notch pathway by DAPT is time- and concentration-dependent, leading to asymmetric growth and multi-eye anomalies in planarians. Exposure to DAPT induces cell proliferation and apoptosis, resulting in neurodevelopmental defects and changes in marker genes.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Medicine, Research & Experimental

FOXP3 facilitates the invasion and metastasis of non-small cell lung cancer cells through regulating VEGF, EMT and the Notch1/Hes1 pathway

Chun Li et al.

Summary: FOXP3 promotes the migratory and invasive abilities of NSCLC cells through regulating VEGF, EMT, and the Notch1/Hes1 pathway.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Biochemistry & Molecular Biology

HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer

Xiaoying Li et al.

Summary: The study indicates that HES1 promotes the stemness properties of BCSC in TNBC by upregulating Slug. TNBC patients with high levels of HES1 and Slug have worse prognosis. HES1 acts as a novel transcriptional activator for Slug, providing new insights for identifying promising prognostic biomarkers and therapeutic targets in TNBC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Medicine, Research & Experimental

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways

Chetan P. Hans et al.

CLINICAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

Comprehensive review of targeted therapy for colorectal cancer

Yuan-Hong Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

Knockdown of SMAD3 inhibits the growth and enhances the radiosensitivity of lung adenocarcinoma via p21 in vitro and in vivo

Hao Niu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Oncology

Agrin has a pathological role in the progression of oral cancer

Cesar Rivera et al.

BRITISH JOURNAL OF CANCER (2018)

Review Biochemistry & Molecular Biology

Proteoglycans Are Attractive Biomarkers and Therapeutic Targets in Hepatocellular Carcinoma

Yasuo Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Cell Biology

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

Sayan Chakraborty et al.

CELL REPORTS (2017)

Review Oncology

Hes1: a key role in stemness, metastasis and multidrug resistance

Zi-Hao Liu et al.

CANCER BIOLOGY & THERAPY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Oncology

RBPJ inhibition impairs the growth of lung cancer

Qun Lv et al.

TUMOR BIOLOGY (2015)

Article Multidisciplinary Sciences

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

Sayan Chakraborty et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

New Pathologic Classification of Lung Cancer: Relevance for Clinical Practice and Clinical Trials

William D. Travis et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

Review Medicine, Research & Experimental

The basics of epithelial-mesenchymal transition

Raghu Kalluri et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Dentistry, Oral Surgery & Medicine

DAPT Enhances the Apoptosis of Human Tongue Carcinoma Cells

Brian E. Grottkau et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2009)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)