The interaction of nicotinic acetylcholine receptor subunits Ld & alpha;3, Ld & alpha;8 and Ld & beta;1 with neonicotinoids in Colorado potato beetle, Leptinotarsa decemlineata

Article Agriculture, Multidisciplinary

Knockdown of the Nicotinic Acetylcholine Receptor β1 Subunit Decreases the Susceptibility to Five Neonicotinoid Insecticides in Whitefly (Bemisia tabaci)

Cheng Yin et al.

Summary: The study found that the BT beta 1 subunit of insect nicotinic acetylcholine receptors plays a role in the susceptibility of B. tabaci to neonicotinoid insecticides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Mutations in the nAChR β1 subunit and overexpression of P450 genes are associated with high resistance to thiamethoxam in melon aphid, Aphis gossypii Glover

Huihui Zhang et al.

Summary: The highly resistant strain TMXR of melon aphids showed mutations in nAChR beta 1 subunit, decreased expression levels of the gene, and higher expression levels of P450s genes compared to susceptible strains. The involvement of nAChRs and CYP450s in the resistance mechanisms were highlighted, suggesting potential targets for overcoming insecticide resistance in Aphis gossypii.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2022)

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Article Entomology

The actions of neonicotinoid insecticides on nicotinic acetylcholine subunits Ldα1 and Ldα8 of Leptinotarsa decemlineata and assembled receptors

Zhi-Min Wang et al.

Summary: This study analyzed the molecular interactions between Ld alpha 1 and Ld alpha 8 subunits of L. decemlineata nAChRs and neonicotinoids, and found that Ld alpha 1 and Ld alpha 8 play an important role in the sensitivity to neonicotinoids.

INSECT SCIENCE (2022)

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Article Agronomy

V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neonicotinoid resistance in Myzus persicae

Xiao Xu et al.

Summary: The R81T and V101I mutations in Myzus persicae are associated with neonicotinoid resistance. The resistance of AH19-T and AH19-I strains to neonicotinoids is mainly caused by these mutations, while the resistance of AH19-TI strain may be influenced by changes in cytochrome P450 monooxygenases and nAChR expression.

PEST MANAGEMENT SCIENCE (2022)

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Article Genetics & Heredity

Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions

Wanjun Lu et al.

Summary: This study systematically examined the susceptibility of fruit fly nAChR subunit mutants to eleven insecticides and found that different subtypes of nAChRs are responsible for the toxicity of different insecticides. Three subtypes were identified as the major molecular targets of neonicotinoids. Spinosyns were found to exclusively act on one specific subtype of nAChRs. The results further confirmed that neonicotinoids exert their insecticidal effects through receptor activation rather than inhibition. These findings have important implications for resistance management and the development of novel insecticides.

PLOS GENETICS (2022)

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Article Biochemistry & Molecular Biology

Dual nicotinic acetylcholine receptor subunit gene knockouts reveal limits to functional redundancy

Wei Chen et al.

Summary: The study reveals the role of nAChR subunits in the biological functions of Drosophila melanogaster. The use of a dual knockout approach helps to identify the specific subunits involved and their functional redundancy. The findings highlight the importance of genetic approaches in understanding the diverse functions of nAChRs in insects.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022)

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Article Agriculture, Multidisciplinary

Knockdown of a Nicotinic Acetylcholine Receptor Subunit Gene Bdorβ1 Decreases Susceptibility to Oxa-Bridged trans- instead of cis- Nitromethylene Neonicotinoid Insecticides in Bactrocera dorsalis

Guo-Rui Yuan et al.

Summary: Nicotinic acetylcholine receptors (nAChRs) play a crucial role in mediating the fast action of acetylcholine in synaptic transmissions. In this study, a gene encoding nAChR beta1 subunit was identified and characterized in a destructive pest, Bactrocera dorsalis. The results suggest that this subunit is involved in the susceptibility of B. dorsalis to a specific class of neonicotinoid insecticides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Trent Perry et al.

Summary: This study systematically investigates the insect response to different classes of insecticides and highlights the specificity of receptor subunits in insecticide resistance. The findings provide new insights into the mode of action of insecticides and reveal a strong conservation of subunit targets across different insect species.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Agronomy