Systemic lupus erythematosus: From non-coding RNAs to exosomal non-coding RNAs

Systemic lupus erythematosus (SLE), as an immunological illness, frequently impacts young females. Both vulnerabilities to SLE and the course of the illness's clinical symptoms have been demonstrated to be affected by individual differences in non-coding RNA expression. Many non-coding RNAs (ncRNAs) are out of whack in patients with SLE. Because of the dysregulation of several ncRNAs in peripheral blood of patients suffering from SLE, these ncRNAs to be showed valuable as biomarkers for medication response, diagnosis, and activity. NcRNAs have also been demonstrated to influence immune cell activity and apoptosis. Altogether, these facts highlight the need of investigating the roles of both families of ncRNAs in the progress of SLE. Being aware of the significance of these transcripts perhaps elucidates the molecular pathogenesis of SLE and could open up promising avenues to create tailored treatments during this condition. In this review we summarized various non-coding RNAs and Exosomal non-coding RNAs in SLE.

Automated summary

Systemic lupus erythematosus (SLE), an immunological illness, affects young females and is influenced by individual differences in non-coding RNA expression. Dysregulation of several non-coding RNAs is observed in SLE patients, making them valuable biomarkers for treatment response, diagnosis, and disease activity. Non-coding RNAs also impact immune cell activity and apoptosis, highlighting the need for further investigation. This review summarizes the role of various non-coding RNAs and exosomal non-coding RNAs in SLE.