The important role of miR-770 as a novel potential diagnostic and therapeutic target for human cancer and other diseases

Review Medicine, Research & Experimental

miR-638: A Promising Cancer Biomarker with Therapeutic Potential

Elham Hasheminasabgorji et al.

Summary: miR-638 may play a crucial role in cancer diagnosis, prognosis, and treatment, but its mechanistic effects are still unclear.

CURRENT MOLECULAR MEDICINE (2023)

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Review Biochemistry & Molecular Biology

MicroRNAs and Long Non-coding RNAs as Novel Targets in Anti-cancer Drug Development

Melisa Cetinkaya et al.

Summary: Non-coding RNAs have crucial regulatory roles in cellular processes, particularly in gene expression. They have emerged as novel targets for anti-cancer drug development, with microRNAs being extensively studied in cancer biology and some microRNA-based therapeutics reaching clinical studies. Long non-coding RNAs are also gaining importance as potential therapeutic targets for cancer therapy. This chapter discusses the strategies and significance of targeting microRNAs and long non-coding RNAs, as well as clinical and preclinical studies involving microRNA and long non-coding RNA-based cancer therapeutics. Additionally, the importance of delivery strategies for effective non-coding RNA-based cancer therapeutics is highlighted.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2023)

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Review Pathology

Roles of non-coding RNAs in cell death pathways involved in the treatment of resistance and recurrence of cancer

Fatemeh Movahedi Motlagh et al.

Summary: In order to control or stop the burden of cancer, various methods have been applied. However, these treatments often fail due to drug resistance or cancer recurrence. Combining the modulation of non-coding RNA (ncRNA) expression with other treatments can increase treatment sensitivity, but there are still challenges to overcome. Gathering information in this field is essential for finding more efficient cancer cures.

PATHOLOGY RESEARCH AND PRACTICE (2023)

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Article Environmental Sciences

LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3

Jing Li et al.

Summary: This study investigated the function of lncRNA MEG3 and its derived miR-770 in PFOS-induced placental toxicity. The results showed that expression levels of MEG3 and miR-770 were reduced in placentas and cells with PFOS exposure, and hypermethylation occurred at the MEG3 promoter. Additionally, overexpression of MEG3 and miR-770 helped alleviate PFOS-induced cell growth inhibition.

ENVIRONMENTAL POLLUTION (2022)

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Review Endocrinology & Metabolism

Non-coding RNAs underlying the pathophysiological links between type 2 diabetes and pancreatic cancer: A systematic review

Fariba Dehghanian et al.

Summary: Type 2 diabetes is a risk factor for pancreatic cancer due to complex genetic and environmental factors, with metabolic abnormalities possibly playing a key role. Shared molecular events, such as metabolic and mitogenic pathways, as well as non-coding RNAs, may be powerful tools in understanding this relationship.

JOURNAL OF DIABETES INVESTIGATION (2022)

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Article Cell Biology

Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer’s disease mice model

Haining Liu et al.

Aging-US (2022)

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Article Biochemistry & Molecular Biology

RNA and Protein Determinants Mediate Differential Binding of miRNAs by a Viral Suppressor of RNA Silencing Thus Modulating Antiviral Immune Responses in Plants

Robert Pertermann et al.

Summary: Plant viruses can produce suppressor proteins that inhibit RNA silencing, a mechanism of antiviral plant immunity. These proteins can bind to virus-derived siRNAs and miRNAs, influencing cellular gene expression. The study found that a specific viral suppressor protein, p19, can bind to different miRNAs with varying affinities due to specific features in the RNA and protein molecules. These findings provide important insights into the efficiency and adaptability of the plant antiviral immune response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Medicine, General & Internal

Identification and Validation of Dilated Cardiomyopathy-Related Genes via Bioinformatics Analysis

Li-Jun Wang et al.

Summary: In this study, we identified differentially expressed miRNAs and mRNAs related to dilated cardiomyopathy (DCM) through bioinformatics analysis. We identified hub genes and candidate drugs associated with DCM, providing new insights for the study of the pathogenesis and clinical treatment of DCM.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Circulating microRNAs Suggest Networks Associated with Biological Functions in Aggressive Refractory Type 2 Celiac Disease

Nicoletta Bianchi et al.

Summary: This study identified a set of microRNAs in serum that can differentiate between different types of refractory diseases and aid in monitoring disease progression. The study also revealed the functions of these microRNAs, including cell signaling, epigenetic regulation, and inflammatory profiles.

BIOMEDICINES (2022)

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Review Oncology

Emerging roles and mechanisms of miR-206 in human disorders: a comprehensive review

Sheyda Khalilian et al.

Summary: miR-206, as a member of the miR-1 family, plays a significant role in various human disorders, including cancers, neurological diseases, and cardiovascular diseases. This review summarizes the role of miR-206 in both malignant and non-malignant situations and discusses its potential therapeutic implications.

CANCER CELL INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway

Bin Jia et al.

Summary: This study identified miR-770 as an upstream regulator of Sirt7 in metastatic OSCC, with higher miR-770 expression correlating with more prominent OSCC metastasis. The results revealed a new role of Sirt7 downregulation in metastatic OSCC and suggested that miR-770 is a potential target in counteracting OSCC metastasis.

IUBMB LIFE (2021)

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Article Biochemistry & Molecular Biology

MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population

Rashin VatanIman et al.

Summary: The study evaluated the expression level of certain miRNAs in serum and tissue samples of Iranian T2DM patients with foot ulcers. The results showed a significant increase in the expression of miRNAs in the blood and tissues of T2DM patients with foot ulcers compared to other groups. Also, miR-571, -661, and -770 were found to be statistically significant in discriminating between T2DM patients with foot ulcers and those without foot ulcers.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Pharmacology & Pharmacy

Analysis of miRNA and mRNA expression in the dysregulation of insulin secretion in MIN6 cells exposed to microcystin-leucine-arginine

Yu Chen et al.

Summary: Exposure to MC-LR inhibits cell viability and impairs insulin secretion in pancreatic beta-cells. Alterations in miRNA and mRNA expression profiles may contribute to the abnormal function of MIN6 cells. Key miRNAs and genes involved in MC-LR-induced cell toxicity were identified, suggesting potential implications for the development of diabetes mellitus.

TOXICON (2021)

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Article Oncology

Comparative mRNA/micro-RNA co-expression network drives melanomagenesis by promoting epithelial-mesenchymal transition and vasculogenic mimicry signaling

WenFeng He et al.

Summary: This study identified PLA1A and DMKN genes as potential oncogenes that trigger the VM and EMT processes in melanomagenesis by interacting with miR-370, miR-563, and miR-770-5p. These genes can serve as diagnostic biomarkers for melanoma and contribute to early diagnosis and prognosis. The altered network involving PLA1A/miR563 and DMNK/miR-770-5p/miR-370 may play a role in melanomagenesis by activating the EMT signaling pathway and VM formation.

TRANSLATIONAL ONCOLOGY (2021)

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Article Medicine, Research & Experimental

miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression

Min Wang et al.

Summary: miR-770-5p expression is significantly increased in patients with type 2 diabetes mellitus (T2DM), and it regulates UA-induced pancreatic beta-cell injury and dysfunction by targeting BAG5.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Oncology

Identifying prognostic lncRNAs based on a ceRNA regulatory network in laryngeal squamous cell carcinoma

Yong Shi et al.

Summary: This study revealed a ceRNA regulatory network in LSCC and identified four lncRNAs associated with patient prognosis. These lncRNAs play a significant role in the progress of LSCC by affecting the proliferation and metastasis of tumor cells.

BMC CANCER (2021)

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Article Neurosciences

CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway

Huan Zhang et al.

Summary: In this study, it was found that circABCC3 regulates glioblastoma development through the miR-770-5p/SOX2 axis and the PI3K/AKT pathway. The absence of circABCC3 inhibited cell proliferation, migration, invasion, and angiogenesis, while inducing apoptosis in glioblastoma.

BRAIN RESEARCH (2021)

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Article Cell Biology

miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A

Senem Noyan et al.

Summary: MicroRNA miR-770-5p downregulates Vimentin and Snail expression levels by targeting DNMT3A, while increasing or restoring E-cadherin expression, inhibiting EMT phenotypes, motility, and invasion. Overexpression of miR-770-5p resulted in a loss of mesenchymal characteristics and gain of epithelial phenotype, effectively inhibiting invasion potential driven by EMT.

CELLULAR SIGNALLING (2021)

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Article Environmental Sciences

miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1

Jiali Yuan et al.

Summary: This study found that miR-770-5p is downregulated in silica-induced pulmonary fibrosis and exerts an anti-fibrotic effect by targeting TGFBR1. Experimental evidence showed that miR-770-5p can reduce fibrotic lesions and control the activation of pulmonary fibroblasts.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Biochemistry & Molecular Biology

A novel circular RNA, circPUS7 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating Kirsten rat sarcoma viral oncogene homolog expression via sponging miR-770

Shuya Pan et al.

Summary: Cadmium is a human carcinogen with unclear mechanisms of inducing cancer. Circular RNAs, a type of epigenetic regulator, have been shown to play key roles in carcinogenesis, but their involvement in cadmium-induced carcinogenesis is not well understood. This study identified a novel circular RNA, circPUS7, which promoted cadmium-induced cell transformation by sponging miR-770 to regulate KRAS expression.

METALLOMICS (2021)

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Article Cell Biology