Expression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses

LINC00174 is an example of long intergenic non-coding RNAs with important functions in the development of human cancers. The gene encoding this lincRNA is located on 7q11.21. LINC00174 has been demonstrated to play an oncogenic role in a variety of cancers, including colorectal carcinoma, thymic carcinoma, glioma, glioblastoma, hepatocellular carcinoma, kidney renal clear cell carcinoma, breast cancer and non-functioning pituitary adenoma. In lung cancer, there is an obvious discrepancy between different studies regarding the role of this lincRNA. This lincRNA is also involved in the determination of prognosis of different cancers, particularly colorectal cancer. In the current review, we discuss the role of this lincRNA in human carcinogenesis based on the available data in the literature and bioinformatics tools.

Automated summary

LINC00174 is a long intergenic non-coding RNA that plays important roles in human cancer development. It has been shown to have oncogenic effects in various cancers, including colorectal carcinoma, thymic carcinoma, glioma, glioblastoma, hepatocellular carcinoma, kidney renal clear cell carcinoma, breast cancer, and non-functioning pituitary adenoma. However, the role of LINC00174 in lung cancer remains uncertain. This lincRNA is also involved in determining the prognosis of different cancers, particularly colorectal cancer. In this review, we discuss the role of LINC00174 in human carcinogenesis based on available literature and bioinformatics tools.