Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 249, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154731
Keywords
Adjacent normal tissue; Cancer invasion; Metastasis; MicroRNA; Oral squamous cell carcinoma
Categories
Ask authors/readers for more resources
This review focuses on the role of miRNAs in oral squamous cell carcinoma (OSCC) and their regulatory mechanisms, suggesting the potential of miRNAs as therapeutic targets. The study is of great significance for understanding and treating OSCC.
Oral squamous cell carcinoma (OSCC) constitutes the most aggressive tumors of the oral cavity and is one of the leading causes of cancer mortality worldwide. Although recent clinical treatment strategies have improved the survival rate, the outcome of OSCC patients still remains dismal because of the lack of efficient diagnostic and treatment tools. As one of the main actors of OSCC scenario, microRNAs (miRNAs) are involved in triggering, progression and metastasis through the regulation of various cancer-related signaling pathways. Identification followed by precise study of the biology and mechanism of action of miRNAs will greatly help to provide valuable insights regarding OSCC development and can be considered as an anti-OSCC target. In the current review, we have provided a focused summary of the latest published papers on the role of miRNAs in apoptosis, cell cycle, proliferation, EMT and metastasis of OSCC as well as the role of long noncoding RNAs in the modulation of miRNAs in OSCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available