A review on the role of MYC-induced long non-coding RNA in human disorders

Article Virology

The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis

Eduardo Gil Perez-Bacho et al.

Summary: This study analyzed the effect of the E6 oncoprotein of HPV16 AA-c variant on cell migration in cervical cancer and discovered the important role of the MINCR/miR-28-5p/RAP1B axis in regulating cell migration.

VIRUSES-BASEL (2022)

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Article Cell Biology

LncRNA MINCR attenuates osteoarthritis progression via sponging miR-146a-5p to promote BMPR2 expression

Dongyun Li et al.

Summary: The study aims to explore the function and regulatory mechanism of a novel lncRNA, MINCR, in osteoarthritis (OA). The findings demonstrate that MINCR prevents OA progression by targeting miR-146a-5p to promote BMPR2 expression.

CELL CYCLE (2022)

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Article Genetics & Heredity

Prognostic value and immunological characteristics of a novel cuproptosis-related long noncoding RNAs risk signature in kidney renal clear cell carcinoma

Peng Hong et al.

Summary: This study established a prognostic signature based on CRLs, which can accurately predict the prognosis of KIRC patients. The reliability and accuracy of the risk signature were verified through K-M survival analysis and time-dependent ROC curve.

FRONTIERS IN GENETICS (2022)

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Review Biochemistry & Molecular Biology

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Jiaqi Liu et al.

Summary: This article provides a comprehensive review of the Wnt/β-catenin pathway, including its origin, composition, function, and clinical trials. It also discusses the challenges and opportunities for developing small-molecule compounds targeting this signaling pathway in disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Medicine, Research & Experimental

Regulatory role of microRNAs on PTEN signaling

Soudeh Ghafouri-Fard et al.

Summary: PTEN gene encodes a tumor suppressor protein that regulates the PI3K/AKT signaling, and its expression is influenced by various transcription factors and miRNAs, playing key roles in cancer therapy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Medicine, Research & Experimental

Role of miRNA and lncRNAs in organ fibrosis and aging

Soudeh Ghafouri-Fard et al.

Summary: Fibrosis is the endpoint of pathological remodeling, with TGF-β, WNT, and YAP/TAZ signaling pathways playing key roles in this process. Long noncoding RNAs and microRNAs participate in organ fibrosis by modulating the activity of related signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

MINCR: A long non-coding RNA shared between cancer and neurodegeneration

Cecilia Pandini et al.

Summary: The multitasking nature of lncRNAs allows them to play a central role in both physiological and pathological conditions. Often the same lncRNA can participate in different diseases. Specifically, the MYC-induced Long nonCoding RNA MINCR is upregulated in various cancer types, while downregulated in Amyotrophic Lateral Sclerosis patients. Therefore, this work aims to investigate MINCR potential mechanisms of action and its implications in cancer and neurodegeneration in relation to its expression levels in SH-SY5Y cells through RNAsequencing approach. Our results show that MINCR overexpression causes massive alterations in cancerrelated genes, leading to disruption in many fundamental processes, such as cell cycle and growth factor signaling. On the contrary, MINCR downregulation influences a small number of genes involved in different neurodegenerative disorders, mostly concerning RNA metabolism and inflammation. Thus, understanding the cause and functional consequences of MINCR deregulation gives important insights on potential pathogenetic mechanisms both in cancer and in neurodegeneration.

GENOMICS (2021)

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Article Biochemistry & Molecular Biology

Depression of lncRNA MINCR antagonizes LPS-evoked acute injury and inflammatory response via miR-146b-5p and the TRAF6-NFkB signaling

Wei Gao et al.

Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.

MOLECULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

Hani Sabaie et al.

Summary: The study developed a lncRNA-related ceRNA network to elucidate molecular regulatory mechanisms involved in SCZ. Our bioinformatics analysis suggested that ceRNAs could be research candidates for investigating SCZ molecular pathways.

SCIENTIFIC REPORTS (2021)

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Article Oncology