Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 248, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154568
Keywords
MINCR; LncRNA; MYC; Cancer
Categories
Ask authors/readers for more resources
MINCR is a lncRNA with a significant correlation with the MYC gene and plays important roles in carcinogenesis. It acts as a molecular sponge for miR-28-5p, miR-708-5p, miR-876-5p, and miR-146a-5p. Dysregulated expression of MINCR has been observed in various cancers, particularly hepatocellular carcinoma. It is also associated with dysregulation of expression patterns in schizophrenia and neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. This review outlines the molecular mechanisms of MINCR in different disorders.
MINCR (MYC-Induced Long Non-Coding RNA) is classified as an lncRNA. It has a significant correlation with MYC gene. MINCR has important roles in the carcinogenesis. It has been approved that this lncRNA can act as molecular sponge for miR-28-5p, miR-708-5p, miR-876-5p and miR-146a-5p. Dysregulated levels of MINCR has been observed in different types of cancer, especially hepatocellular carcinoma. In addition to malignant conditions, schizophrenia and neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis are associated with dysregulation of expression patterns of MINCR. This review outlines MINCR molecular mechanisms of action in different disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
