Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 249, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154758
Keywords
MSCs; Regenerative medicine; Stem cell transplantation; Neurological disorders
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Stem cell therapy is a promising treatment for inflammatory diseases and brain diseases, but it requires thorough evaluation and overcoming challenges before clinical applications.
One of the best treatments for inflammatory diseases such as COVID-19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases. Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.
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